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Dirk Görlich

Dirk Görlich

D-Index & Metrics

Biology and Biochemistry

D-Index
87
Citations
35359
World Ranking
2780
National Ranking
203

Overview

Dirk Görlich is affiliated with the Max Planck Society in Germany and has contributed extensively to the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Their research emphasizes molecular and cellular mechanisms, with a focus on Molecular Biology and Infectious Diseases alongside work in Cell Biology, Radiology, Nuclear Medicine and Imaging, and Cardiology and Cardiovascular Medicine.

Their body of work spans several important topics, including:

  • Nuclear Structure and Function
  • RNA Research and Splicing
  • SARS-CoV-2 and COVID-19 Research
  • Monoclonal and Polyclonal Antibodies Research
  • COVID-19 Clinical Research Studies
  • RNA and protein synthesis mechanisms
  • Cardiomyopathy and Myosin Studies

Dirk Görlich's recent key publications include:

  • "Neutralization of SARS-CoV-2 by highly potent, hyperthermostable, and mutation-tolerant nanobodies," 2021, The EMBO Journal
  • "F-Actin Interactome Reveals Vimentin as a Key Regulator of Actin Organization and Cell Mechanics in Mitosis," 2020, Developmental Cell
  • "HIV-1 capsids enter the FG phase of nuclear pores like a transport receptor," 2024, Nature
  • "Mechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP," 2022, Nature Communications
  • "The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models," 2021, Virus Research

Frequent coauthors in their research collaborations include:

  • Matthias Dobbelstein
  • Antje Dickmanns
  • Kim M. Stegmann
  • Uwe Groß
  • Jürgen Schünemann

Dirk Görlich's work has been published in a variety of scientific journals, with notable frequent publication venues comprising:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • The EMBO Journal
  • Nature
  • iScience

Best Publications

  • Transport between the cell nucleus and the cytoplasm.

    Dirk Görlich;Ulrike Kutay

  • Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs

    Markus T. Bohnsack;Kevin Czaplinski;Dirk Görlich

  • Kinetic analysis of translocation through nuclear pore complexes

    Katharina Ribbeck;Dirk Görlich

  • Isolation of a protein that is essential for the first step of nuclear protein import

    Dirk Görlich;Siegfried Prehn;Ronald A. Laskey;Enno Hartmann

  • Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane

    Dirk Görlich;Tom A. Rapoport

  • Export of Importin α from the Nucleus Is Mediated by a Specific Nuclear Transport Factor

    U. Kutay;F. R. Bischoff;S. Kostka;R. Kraft

  • Identification of different roles for RanGDP and RanGTP in nuclear protein import.

    D. Görlich;N. Panté;U. Kutay;U. Aebi

  • The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus

    Elisa Izaurralde;Ulrike Kutay;Cayetano von Kobbe;Iain W. Mattaj

  • FG-rich repeats of nuclear pore proteins form a three-dimensional meshwork with hydrogel-like properties.

    Steffen Frey;Ralf P. Richter;Ralf P. Richter;Dirk Görlich

  • The permeability barrier of nuclear pore complexes appears to operate via hydrophobic exclusion

    Katharina Ribbeck;Dirk Görlich

  • Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells.

    S. Jäkel;D. Görlich

  • Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope.

    Dirk Görlich;Susanne Kostka;Regine Kraft;Colin Dingwall

  • NTF2 mediates nuclear import of Ran

    Katharina Ribbeck;Gerd Lipowsky;Helen M. Kent;Murray Stewart

  • Distinct functions for the two importin subunits in nuclear protein import

    Dirk Görlich;Frank Vogel;Anthony D. Mills;Enno Hartmann

  • A saturated FG-repeat hydrogel can reproduce the permeability properties of nuclear pore complexes.

    Steffen Frey;Dirk Görlich

  • A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation

    Dirk Görlich;Siegfried Prehn;Enno Hartmann;Kai-Uwe Kalies

  • A Novel Class of RanGTP Binding Proteins

    D. Görlich;M. Dabrowski;F. R. Bischoff;U. Kutay

  • A 41 amino acid motif in importin-alpha confers binding to importin-beta and hence transit into the nucleus.

    D. Görlich;P. Henklein;R. A. Laskey;E. Hartmann

  • Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex.

    U. Kutay;E. Izaurralde;F. R. Bischoff;I. W. Mattaj

  • Structural View of the Ran–Importin β Interaction at 2.3 Å Resolution

    Ingrid R Vetter;Andreas Arndt;Ulrike Kutay;Dirk Görlich

Frequent Co-Authors

Enno Hartmann
Enno Hartmann University of Lübeck
Henning Urlaub
Henning Urlaub University of Göttingen
Ulrike Kutay
Ulrike Kutay ETH Zurich
Tom A. Rapoport
Tom A. Rapoport Harvard University
Regine Kraft
Regine Kraft Max Delbrück Center for Molecular Medicine
Elisa Izaurralde
Elisa Izaurralde Max Planck Institute for Developmental Biology
Markus T. Bohnsack
Markus T. Bohnsack University of Göttingen
Ronald A. Laskey
Ronald A. Laskey University of Cambridge
Iain W. Mattaj
Iain W. Mattaj Human Technopole
Martin Wiedmann
Martin Wiedmann Cornell University

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