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D-Index & Metrics

Molecular Biology

D-Index
94
Citations
31070
World Ranking
658
National Ranking
361

Overview

David V. Schaffer is affiliated with the University of California, Berkeley in the United States. Their research primarily spans the field of Biochemistry, Genetics and Molecular Biology, with a particular focus on Molecular Biology, Genetics, Cell Biology, Biomedical Engineering, and Cellular and Molecular Neuroscience.

They have contributed extensively to topics including:

  • Virus-based gene therapy research
  • CRISPR and Genetic Engineering
  • Cellular Mechanics and Interactions
  • Pluripotent Stem Cells Research
  • 3D Printing in Biomedical Research
  • Photoreceptor and optogenetics research
  • RNA Interference and Gene Delivery

Their recent notable publications include:

  • The delivery challenge: fulfilling the promise of therapeutic genome editing (2020), Nature Biotechnology
  • In vivo hypermutation and continuous evolution (2022), Nature Reviews Methods Primers
  • In vivo-directed evolution of adeno-associated virus in the primate retina (2020), JCI Insight
  • Engineered Illumination Devices for Optogenetic Control of Cellular Signaling Dynamics (2020), Cell Reports
  • Adeno-Associated Virus Vector for Central Nervous System Gene Therapy (2021), Trends in Molecular Medicine

Frequent co-authors collaborating with David V. Schaffer include Sanjay Kumar, Rocío Sampayo, Jieung Baek, Nicole Repina, and Hunter J. Johnson.

Their work has been published in various scientific venues, with recurrent contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Science Advances
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Proceedings of the National Academy of Sciences
  • Biophysical Journal

Best Publications

  • Substrate modulus directs neural stem cell behavior.

    Krishanu Saha;Albert J. Keung;Elizabeth F. Irwin;Yang Li

  • A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons.

    D. Gowanlock R. Tervo;Bum Yeol Hwang;Sarada Viswanathan;Thomas Gaj

  • Engineering adeno-associated viruses for clinical gene therapy

    Melissa A. Kotterman;David V. Schaffer

  • In Vivo???Directed Evolution of a New Adeno-Associated Virus for Therapeutic Outer Retinal Gene Delivery from the Vitreous

    Deniz Dalkara;Leah C. Byrne;Ryan R. Klimczak;Meike Visel

  • The Influence of Hydrogel Modulus on the Proliferation and Differentiation of Encapsulated Neural Stem Cells

    Akhilesh Banerjee;Manish Arha;Soumitra Choudhary;Randolph S. Ashton

  • Stochastic Gene Expression in a Lentiviral Positive-Feedback Loop: HIV-1 Tat Fluctuations Drive Phenotypic Diversity

    Leor S. Weinberger;John C. Burnett;John C. Burnett;Jared E. Toettcher;Adam P. Arkin;Adam P. Arkin

  • Vector unpacking as a potential barrier for receptor‐mediated polyplex gene delivery

    David V. Schaffer;Nick A. Fidelman;Nily Dan;Douglas A. Lauffenburger

  • Directed evolution of adeno-associated virus yields enhanced gene delivery vectors.

    Narendra Maheshri;James T Koerber;Brian K Kaspar;David V Schaffer

  • The AAV Vector Toolkit: Poised at the Clinical Crossroads

    Aravind Asokan;David V Schaffer;David V Schaffer;R Jude Samulski

  • Optogenetic protein clustering and signaling activation in mammalian cells

    Lukasz J Bugaj;Atri T Choksi;Colin K Mesuda;Ravi S Kane

  • Biophysical regulation of epigenetic state and cell reprogramming

    Timothy L. Downing;Jennifer Soto;Constant Morez;Constant Morez;Timothee Houssin;Timothee Houssin

  • PI3K/Akt and CREB regulate adult neural hippocampal progenitor proliferation and differentiation

    Joseph Peltier;Analeah O'Neill;David V. Schaffer

  • Viral Vectors for Gene Therapy: Translational and Clinical Outlook

    Melissa A. Kotterman;Thomas W. Chalberg;David V. Schaffer

  • Single-cell western blotting

    Alex J Hughes;Dawn P Spelke;Zhuchen Xu;Chi-Chih Kang

  • Inner limiting membrane barriers to AAV-mediated retinal transduction from the vitreous.

    Deniz Dalkara;Kathleen D Kolstad;Natalia Caporale;Meike Visel

  • A fully defined and scalable 3D culture system for human pluripotent stem cell expansion and differentiation

    Yuguo Lei;David V. Schaffer

  • Transforming Growth Factor‐β and Notch Signaling Mediate Stem Cell Differentiation into Smooth Muscle Cells

    Kyle Kurpinski;Hayley Lam;Julia Chu;Aijun Wang

  • Quantitative Magnetic Particle Imaging Monitors the Transplantation, Biodistribution, and Clearance of Stem Cells In Vivo.

    Bo Zheng;Marc Philip von See;Elaine Yu;Beliz Gunel

  • Nox2 redox signaling maintains essential cell populations in the brain

    Bryan C Dickinson;Joseph Peltier;Daniel Stone;David V Schaffer

  • Supplemental Data: Stochastic Gene Expression in a Lentiviral Positive Feedback Loop: HIV-1 Tat Fluctuations Drive Phenotypic Diversity

    Leor S Weinberger;John C Burnett;Jared E Toettcher;Adam P Arkin

Frequent Co-Authors

John G. Flannery
John G. Flannery University of California, Berkeley
Kevin E. Healy
Kevin E. Healy University of California, Berkeley
Adam P. Arkin
Adam P. Arkin Lawrence Berkeley National Laboratory
Deniz Dalkara
Deniz Dalkara Inserm : Institut national de la santé et de la recherche médicale
Ravi S. Kane
Ravi S. Kane Georgia Institute of Technology
David Kirn
David Kirn University of California, Berkeley
William H. Merigan
William H. Merigan University of Rochester
Brian K. Kaspar
Brian K. Kaspar Insmed Incorporated
Douglas S. Clark
Douglas S. Clark University of California, Berkeley
Joshua T. Dudman
Joshua T. Dudman Howard Hughes Medical Institute

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