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Chemistry

D-Index
79
Citations
21497
World Ranking
3629
National Ranking
1169

Research.com Recognitions

  • 2019 - Member of the National Academy of Engineering For advances in biocatalyst and bioreaction engineering for drug discovery, drug screening, and bioprocessing.

Overview

Douglas S. Clark is affiliated with the University of California, Berkeley in the United States. Their research focuses extensively on biochemistry, genetics, and molecular biology, with significant contributions across several specialized subfields. These subfields include molecular biology, renewable energy, sustainability and the environment, organic chemistry, biomedical engineering, and environmental engineering.

Clark's work addresses multiple scientific topics, primarily involving microbial fuel cells and bioremediation, enzyme catalysis and immobilization, cyclopropane reaction mechanisms, biodegradable polymer synthesis and properties, electrocatalysts for energy conversion, asymmetric hydrogenation and catalysis, and microbial metabolic engineering and bioproduction.

Key recent publications illustrate the scope of Clark's studies. Among them are:

  • Unnatural biosynthesis by an engineered microorganism with heterologously expressed natural enzymes and an artificial metalloenzyme, 2021, Nature Chemistry
  • Abiotic reduction of ketones with silanes catalysed by carbonic anhydrase through an enzymatic zinc hydride, 2021, Nature Chemistry
  • Towards a Biomanufactory on Mars, 2021, Frontiers in Astronomy and Space Sciences
  • Complete integration of carbene-transfer chemistry into biosynthesis, 2023, Nature
  • Phase-separated biomolecular condensates for biocatalysis, 2023, Trends in Biotechnology

Clark frequently publishes in several scientific venues including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biotechnology and Bioengineering
  • Journal of the American Chemical Society
  • Nature Chemistry
  • Trends in Biotechnology

Collaborative efforts are a part of Clark's research activities, working regularly with coauthors such as Anthony J. Abel, Adam P. Arkin, John F. Hartwig, Brandon J. Bloomer, and Dominic J. Glover.

In recognition of their contributions to the field, Clark was named a Member of the National Academy of Engineering in 2019 for advances in biocatalyst and bioreaction engineering relevant to drug discovery, drug screening, and bioprocessing.

Best Publications

  • Metagenomic discovery of biomass-degrading genes and genomes from cow rumen.

    Matthias Hess;Matthias Hess;Alexander Sczyrba;Alexander Sczyrba;Rob Egan;Rob Egan;Tae Wan Kim

  • Long-term antibacterial efficacy of air plasma-activated water

    Matthew J Traylor;Matthew J Pavlovich;Sharmin Karim;Pritha Hait

  • Pressure effects on intra- and intermolecular interactions within proteins

    Boonchai B Boonyaratanakornkit;Chan Beum Park;Douglas S Clark

  • Abiological catalysis by artificial haem proteins containing noble metals in place of iron

    Hanna M. Key;Paweł Dydio;Paweł Dydio;Douglas S. Clark;John F. Hartwig;John F. Hartwig

  • Integration of chemical catalysis with extractive fermentation to produce fuels

    Pazhamalai Anbarasan;Pazhamalai Anbarasan;Zachary C. Baer;Zachary C. Baer;Sanil Sreekumar;Sanil Sreekumar;Elad Gross;Elad Gross

  • Ionic liquid pretreatment of cellulosic biomass: enzymatic hydrolysis and ionic liquid recycle

    Harvey W. Blanch;Sasisanker Padmanabhan

  • Enzymatic catalysis and dynamics in low-water environments.

    Rhett Affleck;Zu-Feng Xu;Valerie Suzawa;Kathleen Focht

  • An artificial metalloenzyme with the kinetics of native enzymes

    P. Dydio;P. Dydio;H. M. Key;H. M. Key;A. Nazarenko;J. Y.-E. Rha

  • Three-dimensional cellular microarray for high-throughput toxicology assays.

    Moo Yeal Lee;R. Anand Kumar;Sumitra M. Sukumaran;Michael G. Hogg

  • Salts dramatically enhance activity of enzymes suspended in organic solvents

    Yuri L. Khmelnitsky;Stephanie H. Welch;Douglas S. Clark;Jonathan S. Dordick

  • Conformational properties of the complexes formed by proteins and sodium dodecyl sulfate

    Wayne L. Mattice;James M. Riser;Donald S. Clark

  • High-throughput cellular microarray platforms: applications in drug discovery, toxicology and stem cell research

    Tiago G. Fernandes;Maria Margarida Diogo;Douglas S. Clark;Jonathan S. Dordick

  • Ozone correlates with antibacterial effects from indirect air dielectric barrier discharge treatment of water

    Matthew J Pavlovich;Hung-Wen Chang;Hung-Wen Chang;Yukinori Sakiyama;Douglas S Clark

  • Role of alcohols in growth, lipid composition, and membrane fluidity of yeasts, bacteria, and archaea.

    Sarah Huffer;Melinda E. Clark;Jonathan C. Ning;Harvey W. Blanch

  • Molecularly-imprinted material made by template-directed synthesis

    Michael A. Markowitz;Paul E. Schoen;Bruce P. Gaber;Banahalli R. Ratna

  • Nature Versus Nurture: Developing Enzymes That Function Under Extreme Conditions

    Michael J. Liszka;Melinda E. Clark;Elizabeth Schneider;Douglas S. Clark

  • Enzymatic oxidation of cholesterol aggregates in supercritical carbon dioxide.

    T. W. Randolph;D. S. Clark;H. W. Blanch;J. M. Prausnitz

  • Biocatalysis in semi-aqueous and nearly anhydrous conditions.

    Elton P Hudson;Ross K Eppler;Douglas S Clark

  • Cytochrome P450 (CYP) enzymes and the development of CYP biosensors.

    Elizabeth Schneider;Douglas S. Clark

  • Chemoselective, enzymatic C-H bond amination catalyzed by a cytochrome P450 containing an Ir(Me)-PIX cofactor

    Paweł Dydio;Paweł Dydio;Hanna M. Key;Hanna M. Key;Hiroki Hayashi;Hiroki Hayashi;Douglas S. Clark;Douglas S. Clark

  • Photopatterning enzymes on polymer monoliths in microfluidic devices for steady-state kinetic analysis and spatially separated multi-enzyme reactions.

    Timothy C. Logan;Douglas S. Clark;Timothy B. Stachowiak;Frantisek Svec

  • Metabolizing enzyme toxicology assay chip (MetaChip) for high-throughput microscale toxicity analyses

    Moo-Yeal Lee;Chan Beum Park;Jonathan S. Dordick;Douglas S. Clark

Frequent Co-Authors

Harvey W. Blanch
Harvey W. Blanch University of California, Berkeley
Jonathan S. Dordick
Jonathan S. Dordick Rensselaer Polytechnic Institute
Jay D. Keasling
Jay D. Keasling University of California, Berkeley
John F. Hartwig
John F. Hartwig University of California, Berkeley
John M. Prausnitz
John M. Prausnitz University of California, Berkeley
Edward M. Rubin
Edward M. Rubin Joint Genome Institute
David V. Schaffer
David V. Schaffer University of California, Berkeley
F. Dean Toste
F. Dean Toste University of California, Berkeley
Jeffrey A. Reimer
Jeffrey A. Reimer University of California, Berkeley
Frank T. Robb
Frank T. Robb University of Maryland, Baltimore

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