D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 43 Citations 8,862 76 World Ranking 14556 National Ranking 263

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Cytokine
  • Immune system

Jean-François Gauchat mainly investigates Molecular biology, Immunoglobulin E, Interleukin 4, T cell and CD40. The various areas that Jean-François Gauchat examines in his Molecular biology study include Antigen, Messenger RNA, Exon, CD23 and COS cells. Jean-François Gauchat combines subjects such as Cytokine and Interleukin 10 with his study of Immunoglobulin E.

His studies deal with areas such as Peripheral blood mononuclear cell and Immunoglobulin class switching as well as Interleukin 4. He focuses mostly in the field of Immunoglobulin class switching, narrowing it down to matters related to B-cell proliferation and, in some cases, Cell biology. His T cell study combines topics in areas such as Cytotoxic T cell, T lymphocyte and B cell.

His most cited work include:

  • Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation (476 citations)
  • IgE Versus IgG4 Production Can Be Differentially Regulated by IL-10 (461 citations)
  • Structure and expression of germline epsilon transcripts in human B cells induced by interleukin 4 to switch to IgE production. (311 citations)

What are the main themes of his work throughout his whole career to date?

Jean-François Gauchat spends much of his time researching Molecular biology, Immunology, Cell biology, Cytokine and Immunoglobulin E. His Molecular biology research is multidisciplinary, incorporating perspectives in CD40, T cell, Antigen, B cell and Glycoprotein 130. His work in Immunology covers topics such as In vitro which are related to areas like Pharmacology.

Jean-François Gauchat interconnects Proinflammatory cytokine, Receptor, Cell growth and Antigen-presenting cell in the investigation of issues within Cell biology. Jean-François Gauchat has researched Cytokine in several fields, including Protein subunit, Ciliary neurotrophic factor and CD19. His Immunoglobulin E research is multidisciplinary, relying on both Immunoglobulin class switching, Isotype and Interleukin 4.

He most often published in these fields:

  • Molecular biology (48.21%)
  • Immunology (29.46%)
  • Cell biology (29.46%)

What were the highlights of his more recent work (between 2011-2021)?

  • Cytokine (24.11%)
  • Cell biology (29.46%)
  • Immunology (29.46%)

In recent papers he was focusing on the following fields of study:

The scientist’s investigation covers issues in Cytokine, Cell biology, Immunology, CLCF1 and Receptor. His Cytokine research incorporates themes from Cancer research, Ciliary neurotrophic factor and Bone marrow. His study in Cell biology is interdisciplinary in nature, drawing from both Interleukin 21, IL-2 receptor and Antigen-presenting cell.

His research integrates issues of Defensin and Bacterial protein in his study of Immunology. His CLCF1 research is multidisciplinary, incorporating perspectives in Myeloid and Janus kinase 2. His research in Receptor is mostly focused on Cytokine receptor.

Between 2011 and 2021, his most popular works were:

  • Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells (185 citations)
  • Ciliary neurotrophic factor (CNTF): New facets of an old molecule for treating neurodegenerative and metabolic syndrome pathologies (68 citations)
  • Janus kinase 2/signal transducer and activator of transcription 3 inhibitors attenuate the effect of cardiotrophin-like cytokine factor 1 and human focal segmental glomerulosclerosis serum on glomerular filtration barrier (35 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Cytokine
  • Immune system

Jean-François Gauchat mainly focuses on Cytokine, Immunology, Internal medicine, Endocrinology and Cell biology. The Cytokine study combines topics in areas such as Plasma cell differentiation, Receptor, Interferon type I and Immunopathology. His work in the fields of Internal medicine, such as Renal cortex, Creatinine and Albuminuria, overlaps with other areas such as Cell morphology.

His work is dedicated to discovering how Endocrinology, Janus kinase 2 are connected with Glycoprotein 130 and Janus kinase and other disciplines. His Glycoprotein 130 study combines topics from a wide range of disciplines, such as Cancer research, Leukemia inhibitory factor receptor and Ciliary neurotrophic factor. His work carried out in the field of Cell biology brings together such families of science as Plasma cell, Regulatory T cell differentiation and Cell growth.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation

Yves Delneste;Giovanni Magistrelli;Jean-François Gauchat;Jean-François Haeuw.
Immunity (2002)

744 Citations

IgE Versus IgG4 Production Can Be Differentially Regulated by IL-10

Pascale Jeannin;Sybille Lecoanet;Yves Delneste;Jean-François Gauchat.
Journal of Immunology (1998)

705 Citations

Structure and expression of germline epsilon transcripts in human B cells induced by interleukin 4 to switch to IgE production.

J F Gauchat;D A Lebman;R L Coffman;H Gascan.
Journal of Experimental Medicine (1990)

487 Citations

Human B cell clones can be induced to proliferate and to switch to IgE and IgG4 synthesis by interleukin 4 and a signal provided by activated CD4+ T cell clones.

H Gascan;J F Gauchat;M G Roncarolo;H Yssel.
Journal of Experimental Medicine (1991)

444 Citations

Direct bacterial protein PAMP recognition by human NK cells involves TLRs and triggers α-defensin production

Anick Chalifour;Pascale Jeannin;Jean-François Gauchat;Aline Blaecke.
Blood (2004)

406 Citations

Anti-CD40 monoclonal antibodies or CD4+ T cell clones and IL-4 induce IgG4 and IgE switching in purified human B cells via different signaling pathways.

H Gascan;J F Gauchat;G Aversa;P Van Vlasselaer.
Journal of Immunology (1991)

389 Citations

A soluble form of CTLA-4 generated by alternative splicing is expressed by nonstimulated human T cells.

Giovanni Magistrelli;Pascale Jeannin;Nathalie Herbault;Amélie Benoit de Coignac.
European Journal of Immunology (1999)

357 Citations

CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex.

G C Elson;E Lelièvre;C Guillet;S Chevalier.
Nature Neuroscience (2000)

336 Citations

IL-10 and viral IL-10 prevent IL-4-induced IgE synthesis by inhibiting the accessory cell function of monocytes.

J Punnonen;R de Waal Malefyt;P van Vlasselaer;J F Gauchat.
Journal of Immunology (1993)

274 Citations

Human CD40-ligand: molecular cloning, cellular distribution and regulation of expression by factors controlling IgE production.

Jean-François Gauchat;Jean-Pierre Aubry;Gonzalo Mazzei;Paul Life.
FEBS Letters (1993)

211 Citations

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