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Jean-François Gauchat

Jean-François Gauchat

D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
13495
World Ranking
14282
National Ranking
498

Overview

Jean-François Gauchat is affiliated with the University of Montreal in Canada and conducts research primarily in the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology. Their work spans key subfields including Immunology, Oncology, Genetics, Cancer Research, and Molecular Biology.

The scientist's research topics cover diverse aspects of immunology and genetics. Main topics include Cytokine Signaling Pathways and Interactions, Genetic Associations and Epidemiology, Cancer Genomics and Diagnostics, IL-33, ST2, and ILC Pathways, T-cell and B-cell Immunology, Epigenetics and DNA Methylation, and Blood groups and transfusion.

Jean-François Gauchat has published in several scientific venues, among which the most frequent are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Journal of Immunology
  • Cell
  • Oncogene
  • Frontiers in Immunology

Recent papers authored or co-authored by the scientist include:

  • Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations, 2020, Cell
  • Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations, 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • Loss of interleukin-17 receptor D promotes chronic inflammation-associated tumorigenesis, 2020, Oncogene
  • Loss of CD96 Expression as a Marker of HIV-Specific CD8+ T-Cell Differentiation and Dysfunction, 2021, Frontiers in Immunology
  • A PROXIMITY LIGATION SCREEN IDENTIFIES SNAT2 AS A NOVEL TARGET OF THE MARCH1 E3 UBIQUITIN LIGASE, 2024, bioRxiv (Cold Spring Harbor Laboratory)

Jean-François Gauchat collaborates frequently with several coauthors, including:

  • Véronique Laplante
  • Sarah Pasquin
  • Sylvie Lesage
  • Marine Rousseau
  • Ming-Huei Chen

Best Publications

  • Induction of human IgE synthesis in B cells by mast cells and basophils

    Jean François Gauchat;Sybille Henchoz;Gonzalo Mazzei;Jean Pierre Aubry

  • IgE Versus IgG4 Production Can Be Differentially Regulated by IL-10

    Pascale Jeannin;Sybille Lecoanet;Yves Delneste;Jean-François Gauchat

  • Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation

    Yves Delneste;Giovanni Magistrelli;Jean-François Gauchat;Jean-François Haeuw

  • Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.

    Ming-Huei Chen;Laura M Raffield;Abdou Mousas;Saori Sakaue

  • Human B cell clones can be induced to proliferate and to switch to IgE and IgG4 synthesis by interleukin 4 and a signal provided by activated CD4+ T cell clones.

    H Gascan;J F Gauchat;M G Roncarolo;H Yssel

  • Direct bacterial protein PAMP recognition by human NK cells involves TLRs and triggers α-defensin production

    Anick Chalifour;Pascale Jeannin;Jean-François Gauchat;Aline Blaecke

  • Structure and expression of germline epsilon transcripts in human B cells induced by interleukin 4 to switch to IgE production.

    J F Gauchat;D A Lebman;R L Coffman;H Gascan

  • Cutting edge: IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells.

    Jérôme Pène;Jean-François Gauchat;Sandrine Lécart;Elodie Drouet

  • Anti-CD40 monoclonal antibodies or CD4+ T cell clones and IL-4 induce IgG4 and IgE switching in purified human B cells via different signaling pathways.

    H Gascan;J F Gauchat;G Aversa;P Van Vlasselaer

  • A soluble form of CTLA-4 generated by alternative splicing is expressed by nonstimulated human T cells.

    Giovanni Magistrelli;Pascale Jeannin;Nathalie Herbault;Amélie Benoit de Coignac

  • CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex.

    G C Elson;E Lelièvre;C Guillet;S Chevalier

  • Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells

    Claudia U Duerr;Connor D A McCarthy;Barbara C Mindt;Manuel Rubio

  • IL-10 and viral IL-10 prevent IL-4-induced IgE synthesis by inhibiting the accessory cell function of monocytes.

    J Punnonen;R de Waal Malefyt;P van Vlasselaer;J F Gauchat

  • Human CD40-ligand: molecular cloning, cellular distribution and regulation of expression by factors controlling IgE production.

    Jean-François Gauchat;Jean-Pierre Aubry;Gonzalo Mazzei;Paul Life

  • Undetectable CD40 ligand expression on T cells and low B cell responses to CD40 binding agonists in human newborns.

    A Durandy;G De Saint Basile;B Lisowska-Grospierre;J F Gauchat

  • CD23 Regulates monocyte activation through a novel interaction with the adhesion molecules CD11b-CD18 and CD11c-CD18

    Sybille Lecoanet-Henchoz;Jean-Francois Gauchat;Jean-Pierre Aubry;Pierre Graber

  • Soluble CD86 is a costimulatory molecule for human T lymphocytes.

    Pascale Jeannin;Giovanni Magistrelli;Jean-Pierre Aubry;Gersende Caron

  • CD86 (B7-2) on Human B Cells: A FUNCTIONAL ROLE IN PROLIFERATION AND SELECTIVE DIFFERENTIATION INTO IgE- AND IgG4-PRODUCING CELLS *

    Pascale Jeannin;Yves Delneste;Sybille Lecoanet-Henchoz;Jean-François Gauchat

  • Thiols decrease human interleukin (IL) 4 production and IL-4-induced immunoglobulin synthesis.

    P Jeannin;Y Delneste;S Lecoanet-Henchoz;J F Gauchat

  • CD40 ligand is functionally expressed on human eosinophils.

    Jean-François Gauchat;Sybille Henchoz;Dilnya Fattah;Gonzalo Mazzei

Frequent Co-Authors

Jean-Yves Bonnefoy
Jean-Yves Bonnefoy Salto Therapeutics
Yves Delneste
Yves Delneste University of Nantes
Pascale Jeannin
Pascale Jeannin University of Nantes
Hugues Gascan
Hugues Gascan Grenoble Alpes University
Sylvie Chevalier
Sylvie Chevalier University of Rouen
Hans Yssel
Hans Yssel Sorbonne University
J E de Vries
J E de Vries AIMM Therapeutics (Netherlands)
Markus H. Heim
Markus H. Heim University Hospital of Basel
Maria Grazia Roncarolo
Maria Grazia Roncarolo Stanford University

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