World's Best Scientists 2026 revealed!
Stefan Rose-John

Stefan Rose-John

Award Badge
Biology and Biochemistry
Germany
2026
Award Badge
Medicine
Germany
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
145
Citations
81253
World Ranking
220
National Ranking
13

Medicine

D-Index
144
Citations
81165
World Ranking
1438
National Ranking
67

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2026 - Research.com Medicine in Germany Leader Award
  • 2025 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2023 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2023 - Research.com Medicine in Germany Leader Award

Overview

Stefan Rose-John is affiliated with Kiel University in Germany and specializes in research primarily within the fields of Medicine and Immunology and Microbiology. Their work spans numerous subfields, including Oncology, Immunology, Molecular Biology, Physiology, and Cancer Research.

Their research encompasses several main topics, notably:

  • Cytokine Signaling Pathways and Interactions
  • Immune Cell Function and Interaction
  • Immune Response and Inflammation
  • Cell Adhesion Molecules Research
  • IL-33, ST2, and ILC Pathways
  • NF-κB Signaling Pathways
  • HER2/EGFR in Cancer Research

Among the recent publications associated with Stefan Rose-John are:

  • "Repopulating Microglia Promote Brain Repair in an IL-6-Dependent Manner" (2020) published in Cell
  • "Targeting IL-6 trans-signalling: past, present and future prospects" (2023) published in Nature Reviews. Immunology
  • "Interleukin-6: obstacles to targeting a complex cytokine in critical illness" (2021) published in The Lancet Respiratory Medicine
  • "Therapeutic Interleukin-6 Trans-signaling Inhibition by Olamkicept (sgp130Fc) in Patients With Active Inflammatory Bowel Disease" (2021) published in Gastroenterology
  • "Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis" (2021) published in Science

Frequent co-authors collaborating with Stefan Rose-John include:

  • Christoph Garbers
  • Dirk Schmidt-Arras
  • Juliane Lokau
  • Neele Schumacher
  • Eithan Galun

Their research findings have been published extensively in several scientific venues. Among the most frequent are:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Hepatology
  • Cells
  • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Best Publications

  • The pro- and anti-inflammatory properties of the cytokine interleukin-6

    Jürgen Scheller;Athena Chalaris;Dirk Schmidt-Arras;Stefan Rose-John

  • IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

    Sergei Grivennikov;Eliad Karin;Janos Terzic;Janos Terzic;Daniel Mucida

  • Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo.

    R Atreya;J Mudter;S Finotto;J Müllberg

  • Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T cell Therapy for Acute Lymphoblastic Leukemia

    David T. Teachey;David T. Teachey;Simon F. Lacey;Pamela A. Shaw;J. Joseph Melenhorst

  • IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6

    Stefan Rose-John

  • IL-6 and Its Soluble Receptor Orchestrate a Temporal Switch in the Pattern of Leukocyte Recruitment Seen during Acute Inflammation

    Suzanne Maria Hurst;Thomas S. Wilkinson;Rachel Mary McLoughlin;Suzanne Jones

  • Soluble receptors for cytokines and growth factors: generation and biological function

    S Rose-John;P C Heinrich

  • TGF-β Suppresses Tumor Progression in Colon Cancer by Inhibition of IL-6 trans-Signaling

    Christoph Becker;Massimo C. Fantini;Christoph Schramm;Hans A. Lehr

  • Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer.

    Marina Lesina;Magdalena U. Kurkowski;Katharina Ludes;Stefan Rose-John

  • IL-6 pathway in the liver: From physiopathology to therapy

    Dirk Schmidt-Arras;Stefan Rose-John

  • Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer.

    Stefan Rose‐John;Jürgen Scheller;Greg Elson;Simon A. Jones

  • The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion.

    Christian Hundhausen;Dominika Misztela;Theo A. Berkhout;Neil Broadway

  • Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

    Simon Arnett Jones;Jürgen Scheller;Stefan Rose-John

  • Soluble gp130 is the natural inhibitor of soluble interleukin‐6 receptor transsignaling responses

    Thomas Jostock;Jürgen Müllberg;Suat Özbek;Raja Atreya

  • A switch from white to brown fat increases energy expenditure in cancer-associated cachexia.

    Michele Petruzzelli;Martina Schweiger;Renate Schreiber;Ramon Campos-Olivas

  • Interleukin-6 Family Cytokines

    Stefan Rose-John

  • Interleukin-6 and its receptors: A highly regulated and dynamic system

    Janina Wolf;Stefan Rose-John;Christoph Garbers

  • The soluble interleukin‐6 receptor is generated by shedding

    Müllberg J;Schooltink H;Stoyan T;Günther M

  • Transcriptional profiling identifies Id2 function in dendritic cell development

    Christine Hacker;Ralf D Kirsch;Xin-Sheng Ju;Thomas Hieronymus

  • A bioactive designer cytokine for human hematopoietic progenitor cell expansion

    Martina Fischer;Jutta Goldschmitt;Christian Peschel;Just P. G. Brakenhoff

Frequent Co-Authors

Jürgen Scheller
Jürgen Scheller Heinrich Heine University Düsseldorf
Joachim Grötzinger
Joachim Grötzinger Kiel University
Peter C. Heinrich
Peter C. Heinrich University of Freiburg
Markus F. Neurath
Markus F. Neurath University of Erlangen-Nuremberg
Simon Arnett Jones
Simon Arnett Jones Cardiff University
Brendan J. Jenkins
Brendan J. Jenkins Hudson Institute of Medical Research
Philip Rosenstiel
Philip Rosenstiel Kiel University
Peter R. Galle
Peter R. Galle Johannes Gutenberg University of Mainz
Eithan Galun
Eithan Galun Hebrew University of Jerusalem
Stefan Schreiber
Stefan Schreiber Kiel University

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