The scientist’s investigation covers issues in Cell biology, Cytokine, Immunology, Interleukin 6 and Signal transduction. His research in Cell biology intersects with topics in Common gamma chain, Cytotoxic T cell and Cellular differentiation. His Cytokine research integrates issues from Proinflammatory cytokine, Receptor, Innate immune system and Endocrinology.
His biological study spans a wide range of topics, including Cancer research, Arthritis, Blockade, Interleukin and In vivo. His Signal transduction research is multidisciplinary, incorporating elements of Neurogenesis, Interleukin 20 and Interleukin-6 receptor. In his work, Protein kinase C, Transfection, Cell culture, ADAM10 and Metalloproteinase is strongly intertwined with Molecular biology, which is a subfield of Glycoprotein 130.
Stefan Rose-John mostly deals with Cell biology, Interleukin 6, Receptor, Glycoprotein 130 and Immunology. He works mostly in the field of Cell biology, limiting it down to concerns involving Ectodomain and, occasionally, ADAM10. His research integrates issues of Interleukin, Cancer research and Endocrinology in his study of Interleukin 6.
His studies in Receptor integrate themes in fields like Molecular biology, Interleukin-6 receptor, Cytokine and Fusion protein. His study with Glycoprotein 130 involves better knowledge in Signal transduction. His Immunology study frequently links to related topics such as Blockade.
Stefan Rose-John spends much of his time researching Interleukin 6, Cell biology, Cancer research, Immunology and Cytokine. His Interleukin 6 research includes themes of Phenotype, Interleukin, Endocrinology and Monoclonal antibody. His study in Signal transduction and Glycoprotein 130 is carried out as part of his studies in Cell biology.
His Immunology study integrates concerns from other disciplines, such as Transcription factor and Macrophage. His studies deal with areas such as Inflammation, Immune system and In vivo as well as Cytokine. His study in Receptor is interdisciplinary in nature, drawing from both Interleukin-6 receptor and Intracellular.
His scientific interests lie mostly in Signal transduction, Interleukin 6, Immunology, Receptor and Cytokine. His Signal transduction research is under the purview of Cell biology. His Interleukin 6 study is concerned with Inflammation in general.
His Immunology research incorporates elements of Transcription factor and Cell type. The concepts of his Receptor study are interwoven with issues in Cancer research, Phenotype, Microglia, Disintegrin and Fibrosis. Stefan Rose-John works in the field of Cytokine, focusing on Glycoprotein 130 in particular.
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The pro- and anti-inflammatory properties of the cytokine interleukin-6
Jürgen Scheller;Athena Chalaris;Dirk Schmidt-Arras;Stefan Rose-John.
Biochimica et Biophysica Acta (2011)
IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer
Sergei Grivennikov;Eliad Karin;Janos Terzic;Janos Terzic;Daniel Mucida.
Cancer Cell (2009)
Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo.
R Atreya;J Mudter;S Finotto;J Müllberg.
Nature Medicine (2000)
IL-6 and Its Soluble Receptor Orchestrate a Temporal Switch in the Pattern of Leukocyte Recruitment Seen during Acute Inflammation
Suzanne Maria Hurst;Thomas S. Wilkinson;Rachel Mary McLoughlin;Suzanne Jones.
Soluble receptors for cytokines and growth factors: generation and biological function
S Rose-John;P C Heinrich.
Biochemical Journal (1994)
TGF-β Suppresses Tumor Progression in Colon Cancer by Inhibition of IL-6 trans-Signaling
Christoph Becker;Massimo C. Fantini;Christoph Schramm;Hans A. Lehr.
IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6
International Journal of Biological Sciences (2012)
Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer.
Stefan Rose‐John;Jürgen Scheller;Greg Elson;Simon A. Jones.
Journal of Leukocyte Biology (2006)
Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer.
Marina Lesina;Magdalena U. Kurkowski;Katharina Ludes;Stefan Rose-John.
Cancer Cell (2011)
The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion.
Christian Hundhausen;Dominika Misztela;Theo A. Berkhout;Neil Broadway.
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