H-Index & Metrics Best Publications

H-Index & Metrics

Discipline name H-index Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 119 Citations 58,877 524 World Ranking 278 National Ranking 22
Medicine D-index 113 Citations 44,610 415 World Ranking 2071 National Ranking 76

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Cytokine
  • Enzyme

The scientist’s investigation covers issues in Cell biology, Cytokine, Immunology, Interleukin 6 and Signal transduction. His research in Cell biology intersects with topics in Common gamma chain, Cytotoxic T cell and Cellular differentiation. His Cytokine research integrates issues from Proinflammatory cytokine, Receptor, Innate immune system and Endocrinology.

His biological study spans a wide range of topics, including Cancer research, Arthritis, Blockade, Interleukin and In vivo. His Signal transduction research is multidisciplinary, incorporating elements of Neurogenesis, Interleukin 20 and Interleukin-6 receptor. In his work, Protein kinase C, Transfection, Cell culture, ADAM10 and Metalloproteinase is strongly intertwined with Molecular biology, which is a subfield of Glycoprotein 130.

His most cited work include:

  • The pro- and anti-inflammatory properties of the cytokine interleukin-6 (1767 citations)
  • IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer (1523 citations)
  • Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo. (1072 citations)

What are the main themes of his work throughout his whole career to date?

Stefan Rose-John mostly deals with Cell biology, Interleukin 6, Receptor, Glycoprotein 130 and Immunology. He works mostly in the field of Cell biology, limiting it down to concerns involving Ectodomain and, occasionally, ADAM10. His research integrates issues of Interleukin, Cancer research and Endocrinology in his study of Interleukin 6.

His studies in Receptor integrate themes in fields like Molecular biology, Interleukin-6 receptor, Cytokine and Fusion protein. His study with Glycoprotein 130 involves better knowledge in Signal transduction. His Immunology study frequently links to related topics such as Blockade.

He most often published in these fields:

  • Cell biology (30.93%)
  • Interleukin 6 (31.35%)
  • Receptor (28.71%)

What were the highlights of his more recent work (between 2015-2021)?

  • Interleukin 6 (31.35%)
  • Cell biology (30.93%)
  • Cancer research (18.59%)

In recent papers he was focusing on the following fields of study:

Stefan Rose-John spends much of his time researching Interleukin 6, Cell biology, Cancer research, Immunology and Cytokine. His Interleukin 6 research includes themes of Phenotype, Interleukin, Endocrinology and Monoclonal antibody. His study in Signal transduction and Glycoprotein 130 is carried out as part of his studies in Cell biology.

His Immunology study integrates concerns from other disciplines, such as Transcription factor and Macrophage. His studies deal with areas such as Inflammation, Immune system and In vivo as well as Cytokine. His study in Receptor is interdisciplinary in nature, drawing from both Interleukin-6 receptor and Intracellular.

Between 2015 and 2021, his most popular works were:

  • Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T cell Therapy for Acute Lymphoblastic Leukemia (481 citations)
  • IL-6 pathway in the liver: From physiopathology to therapy (293 citations)
  • Interleukin-6: designing specific therapeutics for a complex cytokine (173 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Internal medicine

His scientific interests lie mostly in Signal transduction, Interleukin 6, Immunology, Receptor and Cytokine. His Signal transduction research is under the purview of Cell biology. His Interleukin 6 study is concerned with Inflammation in general.

His Immunology research incorporates elements of Transcription factor and Cell type. The concepts of his Receptor study are interwoven with issues in Cancer research, Phenotype, Microglia, Disintegrin and Fibrosis. Stefan Rose-John works in the field of Cytokine, focusing on Glycoprotein 130 in particular.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

The pro- and anti-inflammatory properties of the cytokine interleukin-6

Jürgen Scheller;Athena Chalaris;Dirk Schmidt-Arras;Stefan Rose-John.
Biochimica et Biophysica Acta (2011)

2729 Citations

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

Sergei Grivennikov;Eliad Karin;Janos Terzic;Janos Terzic;Daniel Mucida.
Cancer Cell (2009)

2011 Citations

Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo.

R Atreya;J Mudter;S Finotto;J Müllberg.
Nature Medicine (2000)

1725 Citations

IL-6 and Its Soluble Receptor Orchestrate a Temporal Switch in the Pattern of Leukocyte Recruitment Seen during Acute Inflammation

Suzanne Maria Hurst;Thomas S. Wilkinson;Rachel Mary McLoughlin;Suzanne Jones.
Immunity (2001)

890 Citations

Soluble receptors for cytokines and growth factors: generation and biological function

S Rose-John;P C Heinrich.
Biochemical Journal (1994)

880 Citations

TGF-β Suppresses Tumor Progression in Colon Cancer by Inhibition of IL-6 trans-Signaling

Christoph Becker;Massimo C. Fantini;Christoph Schramm;Hans A. Lehr.
Immunity (2004)

800 Citations

IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6

Stefan Rose-John.
International Journal of Biological Sciences (2012)

765 Citations

Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer.

Stefan Rose‐John;Jürgen Scheller;Greg Elson;Simon A. Jones.
Journal of Leukocyte Biology (2006)

763 Citations

Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer.

Marina Lesina;Magdalena U. Kurkowski;Katharina Ludes;Stefan Rose-John.
Cancer Cell (2011)

710 Citations

The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion.

Christian Hundhausen;Dominika Misztela;Theo A. Berkhout;Neil Broadway.
Blood (2003)

694 Citations

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