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Simon Arnett Jones

Simon Arnett Jones

D-Index & Metrics

Immunology

D-Index
77
Citations
27277
World Ranking
1797
National Ranking
159

Overview

Simon Arnett Jones is affiliated with Cardiff University in the United Kingdom and specializes in research spanning medicine, immunology and microbiology, as well as biochemistry, genetics, and molecular biology.

Their research work covers diverse topics including cytokine signaling pathways and interactions, peroxisome proliferator-activated receptors, lysosomal storage disorders, T-cell and B-cell immunology, COVID-19 clinical research, eicosanoids and hypertension pharmacology, and immune cell function and interaction.

Simon Arnett Jones has published extensively, with a significant number of contributions to immunology and related fields. Notable recent papers include:

  • "Potential Role of Oral Rinses Targeting the Viral Lipid Envelope in SARS-CoV-2 Infection," 2020, Function
  • "Is IL-6 a key cytokine target for therapy in COVID-19?" 2021, Nature reviews. Immunology
  • "T H 17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity," 2020, Science Immunology
  • "Cardiometabolic Traits, Sepsis, and Severe COVID-19," 2020, Circulation
  • "Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation," 2022, Nature Communications

Frequent coauthors who have collaborated with Simon Arnett Jones include Gareth W. Jones, Valerie B. O'Donnell, Ana Cardus Figueras, Victoria J. Tyrrell, and Barbara Szomolay.

Key venues for publication include bioRxiv (Cold Spring Harbor Laboratory), Molecular Genetics and Metabolism, Lara D. Veeken, Function, and Nature reviews. Immunology.

Their research integrates aspects of immunology, oncology, molecular biology, physiology, and epidemiology, reflecting a multidisciplinary approach to biomedical science.

Best Publications

  • IL-6 as a keystone cytokine in health and disease

    Christopher A. Hunter;Simon Arnett Jones

  • Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes.

    M Loetscher;B Gerber;P Loetscher;S A Jones

  • Directing transition from innate to acquired immunity: defining a role for IL-6.

    Simon A. Jones

  • Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer

    Simon A. Jones;Brendan J. Jenkins

  • IL-6 and Its Soluble Receptor Orchestrate a Temporal Switch in the Pattern of Leukocyte Recruitment Seen during Acute Inflammation

    Suzanne Maria Hurst;Thomas S. Wilkinson;Rachel Mary McLoughlin;Suzanne Jones

  • Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer.

    Stefan Rose‐John;Jürgen Scheller;Greg Elson;Simon A. Jones

  • The soluble interleukin 6 receptor: mechanisms of production and implications in disease

    Simon A. Jones;Sankichi Horiuchi;Nicholas Topley;Naoki Yamamoto

  • Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

    Simon Arnett Jones;Jürgen Scheller;Stefan Rose-John

  • Ectopic lymphoid-like structures in infection, cancer and autoimmunity

    Costantino Pitzalis;Gareth Wyn Jones;Michele Bombardieri;Simon Arnett Jones

  • Expression of phagocyte NADPH oxidase components in human endothelial cells.

    S. A. Jones;V. B. O'donnell;J. D. Wood;J. P. Broughton

  • IL-6 regulates neutrophil trafficking during acute inflammation via STAT3.

    Ceri Alan Fielding;Rachel Mary McLoughlin;Louise McLeod;Chantal Sophie Colmont

  • Regulatory B cells are induced by gut microbiota-driven interleukin-1β and interleukin-6 production.

    Elizabeth C. Rosser;Kristine Oleinika;Silvia Tonon;Ronan Doyle

  • IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation

    Rachel Mary McLoughlin;Brendan J. Jenkins;Dianne Grail;Anwen Sian Williams

  • Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils

    Athena Chalaris;Björn Rabe;Krzysztof Paliga;Hans Lange

  • Interleukin-6 Signaling Drives Fibrosis in Unresolved Inflammation

    Ceri A. Fielding;Gareth Wyn Jones;Rachel Mary McLoughlin;Louise McLeod

  • The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal.

    Marcela Rosas;Luke C. Davies;Peter J. Giles;Chia Te Liao

  • Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling.

    Brendan John Jenkins;Dianne Grail;Thao Nheu;Meri Najdovska

  • IL-6 transsignaling: the in vivo consequences.

    Simon A Jones;Peter J Richards;Jürgen Scheller;Stefan Rose-John

  • The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complex.

    Simon A Jones;Stefan Rose-John

  • Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation

    Luke Cynlais Davies;Marcela Rosas;Stephen J. Jenkins;Chia-Te Liao

  • Interplay between IFN-γ and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation

    Rachel Mary McLoughlin;Janusz Witowski;Rachel L. Robson;Thomas S. Wilkinson

Frequent Co-Authors

Nicholas Topley
Nicholas Topley Cardiff University
Philip R. Taylor
Philip R. Taylor Cardiff University
Stefan Rose-John
Stefan Rose-John Kiel University
Valerie B. O'Donnell
Valerie B. O'Donnell Cardiff University
Brendan J. Jenkins
Brendan J. Jenkins Hudson Institute of Medical Research
Jürgen Scheller
Jürgen Scheller Heinrich Heine University Düsseldorf
Naoki Yamamoto
Naoki Yamamoto Kyoto University
Awen Gallimore
Awen Gallimore Cardiff University
Ernest Choy
Ernest Choy Cardiff University
Edward Chung Yern Wang
Edward Chung Yern Wang Cardiff University

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