World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
76
Citations
18647
World Ranking
18884
National Ranking
1707

Overview

Nicholas Topley is affiliated with Cardiff University in the United Kingdom. Their research spans multiple fields, primarily focusing on medicine, health professions, and computer science. Within these broad areas, their work delves into subfields such as artificial intelligence, immunology, nephrology, oncology, and health information management.

The scientist's publication record includes recent papers addressing topics related to dialysis, immune response, cytokine signaling, and machine learning applications in healthcare. Notable papers published by Nicholas Topley include:

  • Measurement of innate immune response biomarkers in peritoneal dialysis effluent using a rapid diagnostic point-of-care device as a diagnostic indicator of peritonitis, 2020, Kidney International
  • Th1 Cells Alter the Inflammatory Signature of IL-6 by Channeling STAT Transcription Factors to Alu-like Retroelements, 2023, The Journal of Immunology
  • Barriers and facilitators to physical activity: A comparative analysis of transplant athletes competing in high intensity sporting events with other transplant recipients, 2024, PLoS ONE
  • Prediction of the infecting organism in peritoneal dialysis patients with acute peritonitis using interpretable Tsetlin Machines, 2024, Bioinformatics Advances
  • Prediction of the infecting organism in peritoneal dialysis patients with acute peritonitis using interpretable Tsetlin Machines, 2025, bioRxiv (Cold Spring Harbor Laboratory)

Topley's frequent collaborators include Matthias Eberl, David Millrine, Ana Cardus Figueras, Javier Uceda Fernandez, and Robert Andrews. Collaboration with these co-authors has produced multiple publications across different research topics.

The venues where Nicholas Topley publishes underline the diversity of their research. These include bioRxiv (Cold Spring Harbor Laboratory), Kidney International, The Journal of Immunology, PLoS ONE, and Bioinformatics Advances.

The principal topics addressed in their research cover:

  • Dialysis and renal disease management
  • Cytokine signaling pathways and interactions
  • Machine learning in healthcare
  • Artificial intelligence in healthcare
  • Central venous catheters and hemodialysis
  • Health systems, economic evaluations, quality of life
  • Immunodeficiency and autoimmune disorders

Nicholas Topley's work reflects an interdisciplinary approach combining clinical medicine with advanced computational techniques. Their focus on diagnostic technologies, inflammatory and immune mechanisms, and the application of interpretable machine learning methods highlights their contributions to both biomedical research and healthcare innovation.

Best Publications

  • Morphologic Changes in the Peritoneal Membrane of Patients with Renal Disease

    John David Williams;Kathrine Jane Craig;Nicholas Topley;Christopher John Von Ruhland

  • IL-6 and Its Soluble Receptor Orchestrate a Temporal Switch in the Pattern of Leukocyte Recruitment Seen during Acute Inflammation

    Suzanne Maria Hurst;Thomas S. Wilkinson;Rachel Mary McLoughlin;Suzanne Jones

  • The soluble interleukin 6 receptor: mechanisms of production and implications in disease

    Simon A. Jones;Sankichi Horiuchi;Nicholas Topley;Naoki Yamamoto

  • IL-6 regulates neutrophil trafficking during acute inflammation via STAT3.

    Ceri Alan Fielding;Rachel Mary McLoughlin;Louise McLeod;Chantal Sophie Colmont

  • The Euro-Balance Trial: the effect of a new biocompatible peritoneal dialysis fluid (balance) on the peritoneal membrane

    John David Williams;Nicholas Topley;Kathrine Jane Craig;Ruth Kathryn MacKenzie

  • Encapsulating peritoneal sclerosis : Definition, etiology, diagnosis, and treatment

    Yoshindo Kawaguchi;Hideki Kawanishi;Salim Mujais;Nicholas Topley

  • IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation

    Rachel Mary McLoughlin;Brendan J. Jenkins;Dianne Grail;Anwen Sian Williams

  • Interleukin-6 Signaling Drives Fibrosis in Unresolved Inflammation

    Ceri A. Fielding;Gareth Wyn Jones;Rachel Mary McLoughlin;Louise McLeod

  • Interleukin 1-α and tumor necrosis factor-α induce oxygen radical production in mesangial cells

    Heinfried H. Radeke;Beate Meier;Nicholas Topley;Jürgen Flöge

  • Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling.

    Brendan John Jenkins;Dianne Grail;Thao Nheu;Meri Najdovska

  • Soluble IL-6 Receptor Governs IL-6 Activity in Experimental Arthritis: Blockade of Arthritis Severity by Soluble Glycoprotein 130

    Mari Ann Nowell;Peter James Richards;Sankichi Horiuchi;Naoki Yamamoto

  • Interplay between IFN-γ and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation

    Rachel Mary McLoughlin;Janusz Witowski;Rachel L. Robson;Thomas S. Wilkinson

  • Encapsulating peritoneal sclerosis: definition, etiology, diagnosis, and treatment. International Society for Peritoneal Dialysis Ad Hoc Committee on Ultrafiltration Management in Peritoneal Dialysis.

    Kawaguchi Y;Kawanishi H;Mujais S;Topley N

  • The Pathophysiology of the Peritoneal Membrane

    Olivier Devuyst;Peter J. Margetts;Nicholas Topley

  • Human peritoneal mesothelial cells synthesize interleukin-6: Induction by IL-1β and TNFα

    Nicholas Topley;Achim Jörres;Werner Luttmann;Meryl M. Petersen

  • Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis.

    Mari Ann Nowell;Anwen Sian Williams;Sara Madelaine Carty;Jurgen Scheller

  • Interleukin-6 regulation of transforming growth factor (TGF)-beta receptor compartmentalization and turnover enhances TGF-beta1 signaling

    Xiao Liang Zhang;Nicholas Topley;Takafumi Ito;Aled Owain Phillips

  • Regulation of pre–B cell colony‐enhancing factor by STAT‐3–dependent interleukin‐6 trans‐signaling: Implications in the pathogenesis of rheumatoid arthritis

    Mari Ann Nowell;Peter James Richards;Ceri Alan Fielding;Simona Ognjanovic

  • Loss of CD4+ T Cell IL-6R Expression during Inflammation Underlines a Role for IL-6 Trans Signaling in the Local Maintenance of Th17 Cells

    Gareth Wyn Jones;Rachel Mary McLoughlin;Victoria Jayne Hammond;Clare Rhian Parker

  • The effect of dialysate on peritoneal phagocyte oxidative metabolism

    Nicholas Topley;Haifa M.M. Alobaidi;Malcolm Davies;Gerald A. Coles

Frequent Co-Authors

Simon Arnett Jones
Simon Arnett Jones Cardiff University
Matthias Eberl
Matthias Eberl Cardiff University
Philip R. Taylor
Philip R. Taylor Cardiff University
Brendan J. Jenkins
Brendan J. Jenkins Hudson Institute of Medical Research
Simon Jones
Simon Jones Microsoft (United States)
Valerie B. O'Donnell
Valerie B. O'Donnell Cardiff University
Matthias Ernst
Matthias Ernst La Trobe University
Stefan Rose-John
Stefan Rose-John Kiel University
Olivier Devuyst
Olivier Devuyst University of Zurich
Edward Chung Yern Wang
Edward Chung Yern Wang Cardiff University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Embarking on a medical career doesn’t always require attending traditional, on-campus programs. Many students explore diverse healthcare fields and credentials through flexible online options. Accredited medical billing and coding schools online with financial aid can offer affordable entry points into the healthcare industry—ideal for those looking for a quick start and job security.

If you’re aiming to advance your nursing career, there are lpn to rn programs without teas test, making it easier for Licensed Practical Nurses to become Registered Nurses without standardized test barriers. For nursing professionals seeking a smoother transition to advanced roles, consider the pathway offered by rn to np programs, which bridge ADN degrees to MSN and Nurse Practitioner qualifications.

Those interested in the management side of healthcare could benefit from enrolling in the best online healthcare administration degree programs. These fast-track degrees prepare graduates for critical, non-clinical roles in hospitals and healthcare organizations. Exploring these pathways can open numerous rewarding opportunities in the growing healthcare sector.

Best Scientists Citing Nicholas Topley

Trending Scientists

Recently Published Articles