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Johannes N. Spelbrink

Johannes N. Spelbrink

D-Index & Metrics

Genetics

D-Index
52
Citations
13398
World Ranking
3774
National Ranking
135

Johannes N. Spelbrink publication distribution in Genetics in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Genetics in 2026. The highlighted bar marks where Johannes N. Spelbrink sits on this spectrum.

45–54 publications: 6 scientists 55–64 publications: 10 scientists 65–74 publications: 35 scientists 75–84 publications: 84 scientists 85–94 publications: 102 scientists 95–104 publications: 151 scientists 105–114 publications: 175 scientists 115–124 publications: 203 scientists 125–134 publications: 217 scientists 135–144 publications: 205 scientists 145–154 publications: 193 scientists 155–164 publications: 188 scientists 165–174 publications: 170 scientists 175–184 publications: 178 scientists 185–194 publications: 164 scientists 195–204 publications: 173 scientists 205–214 publications: 159 scientists 215–224 publications: 134 scientists 225–234 publications: 143 scientists 235–244 publications: 105 scientists 245–254 publications: 114 scientists 255–264 publications: 92 scientists 265–274 publications: 88 scientists 275–284 publications: 87 scientists 285–294 publications: 80 scientists 295–304 publications: 62 scientists 305–314 publications: 75 scientists 315–324 publications: 67 scientists 325–334 publications: 60 scientists 335–344 publications: 52 scientists 345–354 publications: 40 scientists 355–364 publications: 48 scientists 365–374 publications: 47 scientists 375–384 publications: 46 scientists 385–394 publications: 31 scientists 395–404 publications: 27 scientists 405–414 publications: 40 scientists 415–424 publications: 30 scientists 425–434 publications: 43 scientists 435–444 publications: 29 scientists 445–454 publications: 14 scientists 455–464 publications: 28 scientists 465–474 publications: 21 scientists 475–484 publications: 21 scientists 485–494 publications: 22 scientists 495–504 publications: 17 scientists 505–514 publications: 12 scientists 515–524 publications: 11 scientists 525–534 publications: 8 scientists 535–544 publications: 8 scientists 545–554 publications: 14 scientists 555–564 publications: 4 scientists 565–574 publications: 11 scientists 575–584 publications: 5 scientists 585–594 publications: 11 scientists 595–604 publications: 12 scientists 605–614 publications: 7 scientists 615–624 publications: 6 scientists 625–634 publications: 10 scientists 635–644 publications: 9 scientists 645–654 publications: 10 scientists 655–664 publications: 6 scientists 665–674 publications: 6 scientists 675–684 publications: 6 scientists 685–694 publications: 4 scientists 695–702 publications: 6 scientists 703+ publications: 100 scientists
45 publications 703+

This scientist: 83 publications — 3rd percentile

3% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 703 publications or more.

Johannes N. Spelbrink D-index placement in Genetics in 2026

The chart shows the D-index (discipline H-index) distribution of Genetics scientists ranked by Research.com in 2026. The highlighted bar marks where Johannes N. Spelbrink sits on this spectrum.

40–41 D-Index: 24 scientists 42–43 D-Index: 52 scientists 44–45 D-Index: 84 scientists 46–47 D-Index: 112 scientists 48–49 D-Index: 118 scientists 50–51 D-Index: 141 scientists 52–53 D-Index: 143 scientists 54–55 D-Index: 145 scientists 56–57 D-Index: 179 scientists 58–59 D-Index: 162 scientists 60–61 D-Index: 175 scientists 62–63 D-Index: 191 scientists 64–65 D-Index: 172 scientists 66–67 D-Index: 184 scientists 68–69 D-Index: 164 scientists 70–71 D-Index: 158 scientists 72–73 D-Index: 150 scientists 74–75 D-Index: 136 scientists 76–77 D-Index: 127 scientists 78–79 D-Index: 127 scientists 80–81 D-Index: 111 scientists 82–83 D-Index: 110 scientists 84–85 D-Index: 110 scientists 86–87 D-Index: 84 scientists 88–89 D-Index: 102 scientists 90–91 D-Index: 66 scientists 92–93 D-Index: 72 scientists 94–95 D-Index: 70 scientists 96–97 D-Index: 54 scientists 98–99 D-Index: 60 scientists 100–101 D-Index: 49 scientists 102–103 D-Index: 55 scientists 104–105 D-Index: 45 scientists 106–107 D-Index: 42 scientists 108–109 D-Index: 28 scientists 110–111 D-Index: 39 scientists 112–113 D-Index: 25 scientists 114–115 D-Index: 31 scientists 116–117 D-Index: 29 scientists 118–119 D-Index: 34 scientists 120–121 D-Index: 29 scientists 122–123 D-Index: 29 scientists 124–125 D-Index: 18 scientists 126–127 D-Index: 27 scientists 128–129 D-Index: 22 scientists 130–131 D-Index: 16 scientists 132–133 D-Index: 11 scientists 134–135 D-Index: 17 scientists 136–137 D-Index: 12 scientists 138–139 D-Index: 21 scientists 140–141 D-Index: 4 scientists 142–143 D-Index: 9 scientists 144–145 D-Index: 14 scientists 146–147 D-Index: 6 scientists 148–149 D-Index: 10 scientists 150–151 D-Index: 7 scientists 152–153 D-Index: 9 scientists 154–155 D-Index: 8 scientists 156–157 D-Index: 8 scientists 158–159 D-Index: 9 scientists 160+ D-Index: 96 scientists
40 D-Index 160+

This scientist: 52 D-Index — 14th percentile

14% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 160 D-Index or more.

Overview

Johannes N. Spelbrink is affiliated with Radboud University in the Netherlands. Their primary research domain lies in Biochemistry, Genetics, and Molecular Biology, with 26 publications contributing to this field. More specifically, their work focuses on subfields such as Molecular Biology, Cell Biology, Geriatrics and Gerontology, Cellular and Molecular Neuroscience, and Genetics.

The scientist's research covers several main topics, including:

  • Mitochondrial Function and Pathology
  • RNA modifications and cancer
  • RNA and protein synthesis mechanisms
  • RNA Research and Splicing
  • Metabolomics and Mass Spectrometry Studies
  • Sirtuins and Resveratrol in Medicine
  • Genetic Neurodegenerative Diseases

Their recent notable publications include:

  • "Top3α is the replicative topoisomerase in mitochondrial DNA replication", 2022, Nucleic Acids Research
  • "Mitochondrial RNA processing defect caused by a SUPV3L1 mutation in two siblings with a novel neurodegenerative syndrome", 2022, Journal of Inherited Metabolic Disease
  • "Novel defect in phosphatidylinositol 4-kinase type 2-alpha (PI4K2A) at the membrane-enzyme interface is associated with metabolic cutis laxa", 2020, Journal of Inherited Metabolic Disease
  • "Let's make it clear: systematic exploration of mitochondrial DNA- and RNA-protein complexes by complexome profiling", 2023, Nucleic Acids Research
  • "RNA Crosslinking to Analyze the Mitochondrial RNA-Binding Proteome", 2020, Methods in molecular biology

Johannes N. Spelbrink frequently collaborates with a set of coauthors, including:

  • Alisa Potter
  • Alfredo Cabrera-Orefice
  • Anu Hangas
  • Steffi Goffart
  • Richard J. Rodenburg

Their work has appeared in several publication venues multiple times. Frequent venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nucleic Acids Research
  • Journal of Inherited Metabolic Disease
  • Zenodo (CERN European Organization for Nuclear Research)
  • Methods in molecular biology

Best Publications

  • Premature ageing in mice expressing defective mitochondrial DNA polymerase

    Aleksandra Trifunovic;Anna Wredenberg;Maria Falkenberg;Johannes N. Spelbrink

  • Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria.

    Johannes N. Spelbrink;Fang Yuan Li;Valeria Tiranti;Kaisu Nikali

  • Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production

    Aleksandra Trifunovic;Anna Hansson;Anna Wredenberg;Anja T. Rovio

  • What causes mitochondrial DNA deletions in human cells

    Kim J Krishnan;Amy K Reeve;David C Samuels;Patrick F Chinnery

  • TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions

    Inmaculada Martínez-Reyes;Lauren P. Diebold;Hyewon Kong;Michael Schieber

  • Composition and dynamics of human mitochondrial nucleoids

    Nuria Garrido;Lorena Griparic;Eija Jokitalo;Jorma Wartiovaara

  • Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice

    Henna Tyynismaa;Katja Peltola Mjosund;Sjoerd Wanrooij;Ilse Lappalainen

  • Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA copy number

    Henna Tyynismaa;Hiroshi Sembongi;Monika Bokori-Brown;Caroline Granycome

  • Infantile onset spinocerebellar ataxia is caused by recessive mutations in mitochondrial proteins Twinkle and Twinky

    Kaisu Nikali;Anu Suomalainen;Juha Saharinen;Mikko Kuokkanen

  • The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization

    Jiuya He;Chih-Chieh Mao;Aurelio Reyes;Hiroshi Sembongi

  • Mutations in the phospholipid remodeling gene SERAC1 impair mitochondrial function and intracellular cholesterol trafficking and cause dystonia and deafness

    Saskia B Wortmann;Frédéric M Vaz;Thatjana Gardeitchik;Lisenka E L M Vissers

  • In Vivo Functional Analysis of the Human Mitochondrial DNA Polymerase POLG Expressed in Cultured Human Cells

    Johannes N. Spelbrink;Janne M. Toivonen;Gerrit A.J. Hakkaart;Johanna M. Kurkela

  • Human Dna2 is a nuclear and mitochondrial DNA maintenance protein.

    Julien P. Duxin;Benjamin Dao;Peter Martinsson;Nina Rajala

  • Functional organization of mammalian mitochondrial DNA in nucleoids: History, recent developments, and future challenges

    Johannes N. Spelbrink

  • Twinkle helicase (PEO1) gene mutation causes mitochondrial DNA depletion.

    Emmanuelle Sarzi;Steffi Goffart;Valérie Serre;Dominique Chrétien

  • Mammalian mitochondrial nucleoids: organizing an independently minded genome.

    Ian J. Holt;Jiuya He;Chih-Chieh Mao;Jerome D. Boyd-Kirkup

  • Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells

    Jaakko L. O. Pohjoismäki;Sjoerd Wanrooij;Anne K. Hyvärinen;Steffi Goffart

  • Human mtDNA sublimons resemble rearranged mitochondrial genoms found in pathological states.

    Olli A. Kajander;Anja T. Rovio;Kari Majamaa;Joanna Poulton

  • Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling

    Steffi Goffart;Helen M. Cooper;Henna Tyynismaa;Henna Tyynismaa;Sjoerd Wanrooij

  • Expression of catalytic mutants of the mtDNA helicase Twinkle and polymerase POLG causes distinct replication stalling phenotypes

    Sjoerd Wanrooij;Steffi Goffart;Jaakko L.O. Pohjoismäki;Takehiro Yasukawa

Frequent Co-Authors

Howard T. Jacobs
Howard T. Jacobs Tampere University
Anu Suomalainen
Anu Suomalainen University of Helsinki
Ian J. Holt
Ian J. Holt Medical Research Council
Joanna Poulton
Joanna Poulton University of Oxford
Richard J. Rodenburg
Richard J. Rodenburg Radboud University
Nils-Göran Larsson
Nils-Göran Larsson Karolinska Institute
Anu Jalanko
Anu Jalanko University of Helsinki
Valeria Tiranti
Valeria Tiranti Istituto Neurologico Carlo Besta
Jan A.M. Smeitink
Jan A.M. Smeitink Radboud University
Massimo Zeviani
Massimo Zeviani University of Padua

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