2013 - Member of Academia Europaea
Jan A.M. Smeitink focuses on Mitochondrion, Genetics, Mutation, Oxidative phosphorylation and Gene. His Mitochondrion research is multidisciplinary, incorporating perspectives in Molecular biology, Mitochondrial DNA, Mitochondrial disease and Mitochondrial translation. The study incorporates disciplines such as Biomarker, Respiratory chain and Pathology in addition to Mitochondrial disease.
His Mutation research includes elements of Endocrinology, Complementary DNA, Complementation, Internal medicine and Peptide sequence. His Oxidative phosphorylation research is included under the broader classification of Biochemistry. His research integrates issues of RNA interference, Protein subunit and Neurospora crassa in his study of Cell biology.
Jan A.M. Smeitink mainly investigates Mitochondrion, Mitochondrial disease, Genetics, Internal medicine and Oxidative phosphorylation. His Mitochondrion study introduces a deeper knowledge of Cell biology. His Mitochondrial disease study also includes fields such as
His work deals with themes such as Gastroenterology, Endocrinology and Mitochondrial myopathy, which intersect with Internal medicine. His biological study spans a wide range of topics, including Oxidoreductase and Biogenesis. Jan A.M. Smeitink combines subjects such as NDUFS4 and Molecular biology with his study of Mutation.
His primary areas of study are Mitochondrial disease, Mitochondrion, Internal medicine, Mitochondrial DNA and Oxidative phosphorylation. His Mitochondrial disease research entails a greater understanding of Genetics. His Mitochondrion study combines topics from a wide range of disciplines, such as Cell, Anesthesia, Biophysics, Membrane potential and mitochondrial fusion.
His Internal medicine research is multidisciplinary, incorporating elements of Gastroenterology and Endocrinology. His Mitochondrial DNA research integrates issues from Lactic acidosis and Molecular biology. Oxidative phosphorylation is a subfield of Biochemistry that Jan A.M. Smeitink studies.
The scientist’s investigation covers issues in Mitochondrial disease, Mitochondrion, Oxidative phosphorylation, Internal medicine and Genetics. His studies in Mitochondrial disease integrate themes in fields like Mutation, Leigh disease, Biomarker and Pathology. His Mitochondrion study combines topics in areas such as Pyruvate dehydrogenase deficiency, Cell, Bioinformatics, Rational design and mitochondrial fusion.
Oxidative phosphorylation is a subfield of Biochemistry that he explores. His Internal medicine study incorporates themes from Gastroenterology, Endocrinology and Crossover study. Genetics and Computational biology are commonly linked in his work.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?
Nathalie M.J. van der Put;Fons Gabreëls;Erik M.B. Stevens;Jan A.M. Smeitink.
American Journal of Human Genetics (1998)
Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy-related lipodystrophy
Kees Brinkman;Jan A Smeitink;Johannes A Romijn;Peter Reiss.
The Lancet (1999)
Adverse effects of reverse transcriptase inhibitors: mitochondrial toxicity as common pathway.
K. Brinkman;H.J.M. ter Hofstede;D.M. Burger;J.A.M. Smeitink.
The genetics and pathology of oxidative phosphorylation.
Jan Smeitink;Lambert van den Heuvel;Salvatore DiMauro.
Nature Reviews Genetics (2001)
The Natural Course of Infantile Pompe’s Disease: 20 Original Cases Compared With 133 Cases From the Literature
Hannerieke M. P. van den Hout;Wim Hop;Otto P. van Diggelen;Jan A. M. Smeitink.
Monogenic Mitochondrial Disorders
Werner J H Koopman;Peter H G M Willems;Jan A M Smeitink.
The New England Journal of Medicine (2012)
Mitochondrial creatine kinase: a key enzyme of aerobic energy metabolism
Markus Wyss;Jan Smeitink;Ron A. Wevers;Theo Wallimann.
Biochimica et Biophysica Acta (1992)
Mitochondrial ATP synthase: architecture, function and pathology
An I. Jonckheere;Jan A. M. Smeitink;Richard J. T. Rodenburg.
Journal of Inherited Metabolic Disease (2012)
Mitochondrial aspartyl-tRNA synthetase deficiency causes leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation
Gert C Scheper;Thom van der Klok;Rob J van Andel;Carola G M van Berkel.
Nature Genetics (2007)
Mammalian Mitochondrial Complex I: Biogenesis, Regulation, and Reactive Oxygen Species Generation
Werner J.H. Koopman;Leo G.J. Nijtmans;Cindy E.J. Dieteren;Peggy Roestenberg.
Antioxidants & Redox Signaling (2010)
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