World's Best Scientists 2026 revealed!

D-Index & Metrics

Genetics

D-Index
112
Citations
134657
World Ranking
487
National Ranking
249

Molecular Biology

D-Index
112
Citations
134657
World Ranking
333
National Ranking
198

Research.com Recognitions

  • 2014 - Member of the National Academy of Sciences
  • 2004 - Fellow of the MacArthur Foundation
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Vamsi K. Mootha is affiliated with Harvard University in the United States and has contributed extensively to the fields of Biochemistry, Genetics, and Molecular Biology, with notable work also intersecting with Medicine. Their research spans several subfields including Molecular Biology, Clinical Biochemistry, Genetics, Cancer Research, and Physiology.

The primary topics of Mootha's work include:

  • Mitochondrial Function and Pathology
  • Metabolism and Genetic Disorders
  • RNA modifications and cancer
  • ATP Synthase and ATPases Research
  • Cancer, Hypoxia, and Metabolism
  • Adipose Tissue and Metabolism
  • RNA and protein synthesis mechanisms

Mootha has published frequently in a range of scientific venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Biological Chemistry
  • Nature
  • Proceedings of the National Academy of Sciences
  • eLife

Recent papers authored or co-authored by Mootha include:

  • "MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations," 2020, Nucleic Acids Research
  • "A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing," 2020, Nature
  • "Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell," 2020, eLife
  • "Genetic Screen for Cell Fitness in High or Low Oxygen Highlights Mitochondrial and Lipid Metabolism," 2020, Cell
  • "CRISPR-free base editors with enhanced activity and expanded targeting scope in mitochondrial and nuclear DNA," 2022, Nature Biotechnology

Frequent collaborators in Mootha's research include Owen S. Skinner, Sarah E. Calvo, Hardik Shah, Jason G. McCoy, and Rohit Sharma, showing ongoing partnerships within the research community.

Mootha's recognition within the scientific community is signified by several awards, including being named a Member of the National Academy of Sciences in 2014, a Fellow of the MacArthur Foundation in 2004, and a Member of the Association of American Physicians.

Best Publications

  • Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

    Aravind Subramanian;Pablo Tamayo;Vamsi K. Mootha;Sayan Mukherjee

  • PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

    Vamsi K Mootha;Cecilia M Lindgren;Cecilia M Lindgren;Karl-Fredrik Eriksson;Aravind Subramanian

  • Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1

    Zhidan Wu;Pere Puigserver;Ulf Andersson;Chenyu Zhang

  • Metabolite profiles and the risk of developing diabetes

    Thomas J Wang;Martin G Larson;Martin G Larson;Ramachandran S Vasan;Ramachandran S Vasan;Susan Cheng;Susan Cheng;Susan Cheng

  • Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals

    Xiaohui Xie;Jun Lu;E. J. Kulbokas;Todd R. Golub

  • A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology

    David J. Pagliarini;Sarah E. Calvo;Betty Chang;Sunil A. Sheth

  • Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

    Joshua M. Baughman;Fabiana Perocchi;Fabiana Perocchi;Hany S. Girgis;Hany S. Girgis;Molly Plovanich;Molly Plovanich

  • mTOR controls mitochondrial oxidative function through a YY1–PGC-1α transcriptional complex

    John T. Cunningham;Joseph T. Rodgers;Daniel H. Arlow;Francisca Vazquez

  • tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

    Michael C. Wei;Tullia Lindsten;Vamsi K. Mootha;Solly Weiler

  • Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

    Mohit Jain;Roland Nilsson;Sonia Sharma;Nikhil Madhusudhan;Nikhil Madhusudhan

  • Defects in Adaptive Energy Metabolism with CNS-Linked Hyperactivity in PGC-1α Null Mice

    Jiandie Lin;Pei Hsuan Wu;Paul T. Tarr;Katrin S. Lindenberg

  • MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins.

    Sarah E. Calvo;Sarah E. Calvo;Karl R. Clauser;Vamsi K. Mootha;Vamsi K. Mootha

  • Proteomic Mapping of Mitochondria in Living Cells via Spatially Restricted Enzymatic Tagging

    Hyun-Woo Rhee;Peng Zou;Namrata D. Udeshi;Jeffrey D. Martell

  • Directed evolution of APEX2 for electron microscopy and proximity labeling.

    Stephanie S Lam;Jeffrey D Martell;Kimberli J Kamer;Thomas J Deerinck

  • MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations.

    Sneha Rath;Sneha Rath;Rohit Sharma;Rohit Sharma;Rahul Gupta;Rahul Gupta;Tslil Ast;Tslil Ast

  • Graph theoretical analysis of magnetoencephalographic functional connectivity in Alzheimer's disease.

    C. J. Stam;W. de Haan;A. Daffertshofer;B. F. Jones

  • Integrated Analysis of Protein Composition, Tissue Diversity, and Gene Regulation in Mouse Mitochondria

    Vamsi K. Mootha;Vamsi K. Mootha;Jakob Bunkenborg;Jesper V. Olsen;Majbrit Hjerrild

  • Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans

    Sarah E. Calvo;David J. Pagliarini;David J. Pagliarini;Vamsi K. Mootha;Vamsi K. Mootha

  • Cytokine Stimulation of Energy Expenditure through p38 MAP Kinase Activation of PPARγ Coactivator-1

    Pere Puigserver;James Rhee;Jiandie Lin;Zhidan Wu

  • MICU1 encodes a mitochondrial EF hand protein required for Ca 2+ uptake

    Fabiana Perocchi;Vishal M. Gohil;Vishal M. Gohil;Hany S. Girgis;Hany S. Girgis;X. Robert Bao;X. Robert Bao

Frequent Co-Authors

Sarah E. Calvo
Sarah E. Calvo Broad Institute
David R. Thorburn
David R. Thorburn Murdoch Children's Research Institute
Steven A. Carr
Steven A. Carr Broad Institute
Salvatore DiMauro
Salvatore DiMauro Columbia University
Clary B. Clish
Clary B. Clish Broad Institute
John Christodoulou
John Christodoulou University of Melbourne
Alice Y. Ting
Alice Y. Ting Stanford University
David Altshuler
David Altshuler Harvard University
Joel N. Hirschhorn
Joel N. Hirschhorn Boston Children's Hospital
Michio Hirano
Michio Hirano Columbia University

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