His primary scientific interests are in Genetics, Mitochondrial DNA, Coenzyme Q10 deficiency, Internal medicine and Mutation. Genetics connects with themes related to Thymidine phosphorylase in his study. His Mitochondrial DNA research is multidisciplinary, incorporating perspectives in Molecular biology, Respiratory chain, Mitochondrion and Point mutation.
In the subject of general Mitochondrion, his work in Mitochondrial respiratory chain is often linked to Bcl-2-associated X protein, thereby combining diverse domains of study. Michio Hirano interconnects Cerebellar ataxia, PDSS2 and Nephropathy in the investigation of issues within Coenzyme Q10 deficiency. The study incorporates disciplines such as Gastroenterology, Endocrinology, Mitochondrial encephalomyopathy and Mitochondrial myopathy in addition to Internal medicine.
His primary areas of investigation include Mitochondrial DNA, Genetics, Internal medicine, Molecular biology and Pathology. His Mitochondrial DNA research is multidisciplinary, relying on both Respiratory chain, Mitochondrion and Point mutation. His study involves Mutation, Gene, Heteroplasmy, Phenotype and Human mitochondrial genetics, a branch of Genetics.
His studies deal with areas such as Gastroenterology and Endocrinology as well as Internal medicine. His study in Molecular biology is interdisciplinary in nature, drawing from both Mitochondrial DNA depletion syndrome, Thymidine phosphorylase, Mutant, Cytochrome c oxidase and Thymidine. In his work, MELAS syndrome is strongly intertwined with Lactic acidosis, which is a subfield of Pathology.
His scientific interests lie mostly in Mitochondrial DNA, Internal medicine, Mitochondrial disease, Mitochondrion and Genetics. His work deals with themes such as Mutation, Molecular biology and Cancer research, which intersect with Mitochondrial DNA. His Mutation course of study focuses on Mitochondrial biogenesis and Penetrance.
His Internal medicine research includes themes of Gastroenterology and Endocrinology. The concepts of his Mitochondrial disease study are interwoven with issues in Lactic acidosis, Clinical research, Disease, Mitochondrial encephalomyopathy and Chronic progressive external ophthalmoplegia. His Mitochondrion research is multidisciplinary, incorporating elements of Protein subunit, Gene and ATP synthase.
Mitochondrion, Genetics, Molecular biology, Mitochondrial DNA and Mutation are his primary areas of study. His Mitochondrion study incorporates themes from Thymidine phosphorylase and Protein subunit, Gene, ATP synthase. The various areas that Michio Hirano examines in his Genetics study include Orphan Drug Act of 1983, Federal Food, Drug, and Cosmetic Act and Institutional review board.
His research integrates issues of Catabolism, Deamination, Deoxycytidine monophosphate, Thymidine and Tetrahydrouridine in his study of Molecular biology. Michio Hirano studies Heteroplasmy which is a part of Mitochondrial DNA. His Mutation study combines topics from a wide range of disciplines, such as Phenotype, Cancer research, NDUFS4 and Mitophagy.
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Thymidine Phosphorylase Gene Mutations in MNGIE, a Human Mitochondrial Disorder
Ichizo Nishino;Antonella Spinazzola;Michio Hirano.
Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease)
Ichizo Nishino;Jin Fu;Kurenai Tanji;Takeshi Yamada.
Human mitochondrial DNA: roles of inherited and somatic mutations
Eric A. Schon;Salvatore DiMauro;Michio Hirano.
Nature Reviews Genetics (2012)
Fatal infantile cardioencephalomyopathy with COX deficiency and mutations in SCO2, a COX assembly gene
L C Papadopoulou;C M Sue;M M Davidson;K Tanji.
Nature Genetics (1999)
MELAS: Clinical features, biochemistry, and molecular genetics
E. Ciafaloni;E. Ricci;S. Shanske;C. T. Moraes.
Annals of Neurology (1992)
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE): Clinical, biochemical, and genetic features of an autosomal recessive mitochondrial disorder
Michio Hirano;G. Silvestri;D. M. Blake;A. Lombes.
Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS): current concepts.
Michio Hirano;Steven G. Pavlakis.
Journal of Child Neurology (1994)
MELAS: An original case and clinical criteria for diagnosis
Michio Hirano;Enzo Ricci;M. Richard Koenigsberger;Richard Defendini.
Neuromuscular Disorders (1992)
Leigh Syndrome with Nephropathy and CoQ10 Deficiency Due to decaprenyl diphosphate synthase subunit 2 (PDSS2) Mutations
Luis Carlos López;Markus Schuelke;Catarina M. Quinzii;Tomotake Kanki.
American Journal of Human Genetics (2006)
Diagnosis and management of mitochondrial disease: a consensus statement from the Mitochondrial Medicine Society
Sumit Parikh;Amy Goldstein;Mary Kay Koenig;Fernando Scaglia.
Genetics in Medicine (2015)
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