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Valerio Carelli

Valerio Carelli

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Genetics
Italy
2026

D-Index & Metrics

Genetics

D-Index
103
Citations
31047
World Ranking
686
National Ranking
8

Medicine

D-Index
105
Citations
32612
World Ranking
6857
National Ranking
228

Research.com Recognitions

  • 2026 - Research.com Genetics in Italy Leader Award
  • 2025 - Research.com Genetics in Italy Leader Award
  • 2024 - Research.com Genetics in Italy Leader Award
  • 2023 - Research.com Genetics in Italy Leader Award

Overview

Valerio Carelli is affiliated with the University of Bologna in Italy. Their research spans key areas in biochemistry, genetics, molecular biology, and medicine, with a strong focus on subfields such as molecular biology, ophthalmology, genetics, clinical biochemistry, and neurology. This multidisciplinary approach reflects in the breadth of topics explored within their scholarly work.

The main topics Carelli investigates include mitochondrial function and pathology, retinal development and disorders, ATP synthase and ATPases research, metabolism and genetic disorders, retinal diseases and treatments, drug-induced ocular toxicity, and photosynthetic processes and mechanisms.

Frequent collaboration marks Carelli's research, with coauthors including Chiara La Morgia, Leonardo Caporali, Patrick Yu-Wai-Man, Piero Barboni, and Thomas Klopstock. Such partnerships contribute to the scope and depth of their work in hereditary optic neuropathies and related molecular mechanisms.

The study venues where Carelli publishes are notable for their focus on neurological and ophthalmological research and include Acta Ophthalmologica, Neurology, Frontiers in Neurology, Brain, and Scientific Reports.

Among Carelli's recent papers are:

  • "Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy," 2020, Science Translational Medicine
  • "Efficacy and Safety of Intravitreal Gene Therapy for Leber Hereditary Optic Neuropathy Treated within 6 Months of Disease Onset," 2021, Ophthalmology
  • "Impaired complex I repair causes recessive Leber's hereditary optic neuropathy," 2021, Journal of Clinical Investigation
  • "Visual Outcomes in Leber Hereditary Optic Neuropathy Patients With the m.11778G>A (MTND4) Mitochondrial DNA Mutation," 2020, Journal of Neuro-Ophthalmology
  • "Therapeutic Options in Hereditary Optic Neuropathies," 2020, Drugs

Best Publications

  • Mitochondrial dysfunction as a cause of optic neuropathies

    Valerio Carelli;Fred N. Ross-Cisneros;Alfredo A. Sadun

  • Disturbed mitochondrial dynamics and neurodegenerative disorders

    Florence Burté;Valerio Carelli;Patrick F. Chinnery;Patrick Yu-Wai-Man

  • The Molecular Dissection of mtDNA Haplogroup H Confirms That the Franco-Cantabrian Glacial Refuge Was a Major Source for the European Gene Pool

    Alessandro Achilli;Chiara Rengo;Chiara Magri;Vincenza Battaglia

  • OPA1 mutations induce mitochondrial DNA instability and optic atrophy plus phenotypes

    Patrizia Amati-Bonneau;Maria Lucia Valentino;Pascal Reynier;Maria Esther Gallardo

  • Proteolytic Cleavage of Opa1 Stimulates Mitochondrial Inner Membrane Fusion and Couples Fusion to Oxidative Phosphorylation

    Prashant Mishra;Valerio Carelli;Giovanni Manfredi;David C. Chan

  • Multi-system neurological disease is common in patients with OPA1 mutations

    Patrick Yu-Wai-Man;Philip G. Griffiths;Philip G. Griffiths;G. Gorman;C.-M. Lourenco

  • Haplotype and phylogenetic analyses suggest that one European-specific mtDNA background plays a role in the expression of Leber hereditary optic neuropathy by increasing the penetrance of the primary mutations 11778 and 14484

    A Torroni;M Petrozzi;L D'Urbano;D Sellitto

  • OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation and mitochondrial fusion.

    Claudia Zanna;Anna Ghelli;Anna Maria Porcelli;Mariusz Karbowski

  • Melanopsin retinal ganglion cell loss in Alzheimer disease

    Chiara La Morgia;Fred N. Ross‐Cisneros;Yosef Koronyo;Jens Hannibal

  • Clinical Expression of Leber Hereditary Optic Neuropathy Is Affected by the Mitochondrial DNA–Haplogroup Background

    Gavin Hudson;Valerio Carelli;Valerio Carelli;Liesbeth Spruijt;Mike Gerards

  • The clinical maze of mitochondrial neurology

    Salvatore DiMauro;Eric A. Schon;Valerio Carelli;Michio Hirano

  • Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage

    Celine Perier;Kim Tieu;Christelle Guégan;Casper Caspersen

  • Efficient mitochondrial biogenesis drives incomplete penetrance in Leber's hereditary optic neuropathy.

    Carla Giordano;Luisa Iommarini;Luca Giordano;Alessandra Maresca

  • Optic nerve degeneration and mitochondrial dysfunction: genetic and acquired optic neuropathies.

    Valerio Carelli;Fred N. Ross-Cisneros;Alfredo A. Sadun

  • Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors

    Giuseppe Gasparre;Anna Maria Porcelli;Elena Bonora;Lucia Fiammetta Pennisi

  • Rescue of a mitochondrial deficiency causing Leber hereditary optic neuropathy

    John Guy;Xiaoping Qi;Francesco Pallotti;Eric A. Schon

  • Retinal nerve fiber layer evaluation by optical coherence tomography in Leber's hereditary optic neuropathy.

    Piero Barboni;Giacomo Savini;Maria Lucia Valentino;Pasquale Montagna

  • Correlation between retinal nerve fibre layer thickness and optic nerve head size: an optical coherence tomography study

    Giacomo Savini;M. Zanini;V. Carelli;A. A. Sadun

  • Retinal ganglion cell neurodegeneration in mitochondrial inherited disorders

    Valerio Carelli;Chiara La Morgia;Maria Lucia Valentino;Piero Barboni

  • Leber's hereditary optic neuropathy Biochemical effect of 11778/ND4 and 3460/ND1 mutations and correlation with the mitochondrial genotype

    Valerio Carelli;A. Ghelli;M. Ratta;E. Bacchilega

Frequent Co-Authors

Alfredo A. Sadun
Alfredo A. Sadun University of California, Los Angeles
Maria Lucia Valentino
Maria Lucia Valentino University of Bologna
Rocco Liguori
Rocco Liguori University of Bologna
Pasquale Montagna
Pasquale Montagna University of Bologna
Massimo Zeviani
Massimo Zeviani University of Padua
Andrea Martinuzzi
Andrea Martinuzzi University of Turin
Patrick Yu-Wai-Man
Patrick Yu-Wai-Man University of Cambridge
Antonio Torroni
Antonio Torroni University of Pavia
Carla Giordano
Carla Giordano Sapienza University of Rome
Rubens Belfort
Rubens Belfort Federal University of Sao Paulo

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