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Genetics
USA
2026
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Genetics and Molecular Biology
USA
2024

D-Index & Metrics

Genetics

D-Index
163
Citations
110092
World Ranking
88
National Ranking
45

Medicine

D-Index
163
Citations
110009
World Ranking
678
National Ranking
391

Research.com Recognitions

  • 2026 - Research.com Genetics in United States Leader Award
  • 2025 - Research.com Genetics in United States Leader Award
  • 2024 - Research.com Genetics in United States Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in United States Leader Award
  • 2023 - Research.com Genetics in United States Leader Award
  • 2017 - Benjamin Franklin Medal, Franklin Institute
  • 2017 - Dr. Paul Janssen Award for Biomedical Research, Johnson & Johnson for pioneering the field of human mitochondrial genetics and its application to the study of disease, aging, and patterns of human migration.
  • 2012 - Gruber Prize in Genetics
  • 2009 - Member of the National Academy of Medicine (NAM)
  • 2005 - Robert J. and Claire Pasarow Foundation Medical Research Award
  • 2004 - Fellow of the American Academy of Arts and Sciences
  • 1999 - Metlife Foundation Award for Medical Research in Alzheimer's Disease
  • 1995 - Member of the National Academy of Sciences

Overview

Douglas C. Wallace is affiliated with the Children's Hospital of Philadelphia in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, spanning a total of 163 publications in these areas. Medicine is another significant field of their work, represented by 67 publications.

Their research covers multiple subfields, including molecular biology, clinical biochemistry, physiology, infectious diseases, and cancer research. The main topics of their studies include mitochondrial function and pathology, metabolism and genetic disorders, RNA modifications and cancer, spaceflight effects on biology, cancer, hypoxia and metabolism, SARS-CoV-2 and COVID-19 research, and ATP synthase and ATPases research.

Douglas C. Wallace has coauthored multiple papers with several frequent collaborators, including Joseph W. Guarnieri, Afshin Beheshti, Stephen B. Baylin, Christopher E. Mason, and Robert Meller. Their work is frequently published in venues such as bioRxiv (Cold Spring Harbor Laboratory), Proceedings of the National Academy of Sciences, Nature Communications, SSRN Electronic Journal, and Cell.

Selected recent papers include:

  • Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration (2020, Cell)
  • Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact (2020, Cell)
  • Lactate Limits T Cell Proliferation via the NAD(H) Redox State (2020, Cell Reports)
  • Mitochondrial DNA variation and cancer (2021, Nature reviews. Cancer)
  • Specifications of the ACMG/AMP standards and guidelines for mitochondrial DNA variant interpretation (2020, Human Mutation)

The scientist has received several awards during their career. These include the Benjamin Franklin Medal from the Franklin Institute in 2017, the Dr. Paul Janssen Award for Biomedical Research by Johnson & Johnson in 2017 for pioneering work in human mitochondrial genetics, the Gruber Prize in Genetics in 2012, membership in the National Academy of Medicine in 2009, the Robert J. and Claire Pasarow Foundation Medical Research Award in 2005, fellowship of the American Academy of Arts and Sciences in 2004, the Metlife Foundation Award for Medical Research in Alzheimer's Disease in 1999, and membership in the National Academy of Sciences in 1995.

Best Publications

  • A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

    Douglas Cecil Wallace

  • Mitochondrial diseases in man and mouse.

    Douglas C. Wallace

  • Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy

    Douglas C. Wallace;Gurparkash Singh;Marie T. Lott;Judy A. Hodge

  • Mitochondria and cancer

    Douglas C. Wallace

  • Dilated Cardiomyopathy and Neonatal Lethality in Mutant Mice Lacking Manganese Superoxide Dismutase

    Yibing Li;Ting-Ting Huang;Elaine J. Carlson;Simon Melov

  • Myoclonic epilepsy and ragged-red fiber disease (MERRF) is associated with a mitochondrial DNA tRNALys mutation

    John M. Shoffner;Marie T. Lott;Angela M.S. Lezza;Peter Seibel

  • Extension of murine life span by overexpression of catalase targeted to mitochondria.

    Samuel E. Schriner;Nancy J. Linford;George M. Martin;Piper Treuting

  • Diseases of the mitochondrial DNA.

    Douglas C. Wallace

  • Mitochondrial genetics: a paradigm for aging and degenerative diseases?

    Douglas C. Wallace

  • Maternal inheritance of human mitochondrial DNA

    Richard E. Giles;Hugues Blanc;Howard M. Cann;Douglas C. Wallace

  • The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore

    Jason E. Kokoszka;Jason E. Kokoszka;Katrina G. Waymire;Katrina G. Waymire;Shawn E. Levy;Shawn E. Levy;James E. Sligh;James E. Sligh

  • Natural selection shaped regional mtDNA variation in humans

    Dan Mishmar;Eduardo Ruiz-Pesini;Pawel Golik;Vincent Macaulay

  • Extension of life-span with superoxide dismutase/catalase mimetics

    Simon Melov;Joanne Ravenscroft;Sarwatt Malik;Matt S. Gill

  • Classification of European Mtdnas from an Analysis of Three European Populations

    Antonio Torroni;Kirsi Huoponen;Paolo Francalacci;Maurizio Petrozzi

  • An Inherited Heteroplasmic Mutation in Mitochondrial Gene COI in a Patient with Prostate Cancer Alters Reactive Oxygen, Reactive Nitrogen and Proliferation

    Rebecca S. Arnold;Qian Sun;Carrie Q. Sun;Jendai C. Richards

  • Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age.

    M Corral-Debrinski;T Horton;M T Lott;J M Shoffner

  • mtDNA mutations increase tumorigenicity in prostate cancer

    John A. Petros;Amanda K. Baumann;Eduardo Ruiz-Pesini;Mahul B. Amin

  • Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain

    P Mecocci;U MacGarvey;A E Kaufman;D Koontz

  • Asian affinities and continental radiation of the four founding Native American mtDNAs.

    A Torroni;T G Schurr;M F Cabell;M D Brown

  • Mitochondrial mutations in cancer.

    M Brandon;P Baldi;D C Wallace

Frequent Co-Authors

Marie T. Lott
Marie T. Lott Children's Hospital of Philadelphia
Antonio Torroni
Antonio Torroni University of Pavia
Vincent Procaccio
Vincent Procaccio University of Angers
Nancy J. Newman
Nancy J. Newman Emory University
Peter Burke
Peter Burke University of California, Riverside
Simon Melov
Simon Melov Buck Institute for Research on Aging
Ian A. Trounce
Ian A. Trounce University of Melbourne
Anthony B. Nesburn
Anthony B. Nesburn University of California, Irvine
Xiaowu Gai
Xiaowu Gai Children's Hospital of Los Angeles
Rosaria Scozzari
Rosaria Scozzari Sapienza University of Rome

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