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Biology and Biochemistry

D-Index
75
Citations
26869
World Ranking
5230
National Ranking
2485

Overview

Simon Melov is affiliated with the Buck Institute for Research on Aging in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with subfields including Physiology, Molecular Biology, Immunology, Aging, and Cardiology and Cardiovascular Medicine.

The scientist's work focuses on key topics such as Telomeres, Telomerase, and Senescence; Neutrophil, Myeloperoxidase and Oxidative Mechanisms; Genetics, Aging, and Longevity in Model Organisms; Single-cell and spatial transcriptomics; Muscle Physiology and Disorders; Atherosclerosis and Cardiovascular Diseases; and Cardiovascular Health and Disease Prevention.

Among their recent publications are:

  • NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health, 2022, Nature Aging
  • Single nuclei profiling identifies cell specific markers of skeletal muscle aging, frailty, and senescence, 2022, Aging
  • Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence, 2023, Aging Cell
  • Cellular Senescence Contributes to Large Elastic Artery Stiffening and Endothelial Dysfunction With Aging: Amelioration With Senolytic Treatment, 2023, Hypertension
  • Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging, 2021, American Journal of Physiology-Heart and Circulatory Physiology

Simon Melov frequently publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), Aging Cell, The FASEB Journal, Hypertension, and the American Journal of Physiology-Heart and Circulatory Physiology.

Collaboration is an important aspect of their research approach. Frequent co-authors include:

  • Judith Campisi
  • Zachary S. Clayton
  • Douglas R. Seals
  • David A. Hutton
  • Vienna E. Brunt

Best Publications

  • Dilated Cardiomyopathy and Neonatal Lethality in Mutant Mice Lacking Manganese Superoxide Dismutase

    Yibing Li;Ting-Ting Huang;Elaine J. Carlson;Simon Melov

  • Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

    Simona Parrinello;Enrique Samper;Ana Krtolica;Joshua Goldstein

  • Extension of life-span with superoxide dismutase/catalase mimetics

    Simon Melov;Joanne Ravenscroft;Sarwatt Malik;Matt S. Gill

  • Cellular senescence promotes adverse effects of chemotherapy and cancer relapse

    Marco Demaria;Marco Demaria;Monique N. O'Leary;Jianhui Chang;Lijian Shao

  • Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress.

    Gordon J. Lithgow;Tiffany M. White;Simon Melov;Thomas E. Johnson

  • From discoveries in ageing research to therapeutics for healthy ageing

    Judith Campisi;Pankaj Kapahi;Gordon J. Lithgow;Simon Melov

  • Radicals r'aging.

    Douglas C. Wallace;Simon Melov

  • Mitochondrial disease in mouse results in increased oxidative stress

    Luke A. Esposito;Simon Melov;Alexander Panov;Barbara A. Cottrell

  • Unmasking Transcriptional Heterogeneity in Senescent Cells

    Alejandra Hernandez-Segura;Tristan V. de Jong;Simon Melov;Victor Guryev

  • Mitochondrial disease in superoxide dismutase 2 mutant mice

    Simon Melov;Pinar Coskun;Manisha Patel;Robbyn Tuinstra

  • A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase

    Simon Melov;Julie A. Schneider;Brian J. Day;Douglas Hinerfeld

  • Analysis of global mRNA expression in human skeletal muscle during recovery from endurance exercise

    D. J. Mahoney;G. Parise;S. Melov;A. Safdar

  • Cellular senescence: a link between cancer and age-related degenerative disease?

    Judith Campisi;Julie K. Andersen;Pankaj Kapahi;Simon Melov

  • Oxidative stress and aging: beyond correlation

    Tamara R. Golden;Douglas A. Hinerfeld;Simon Melov

  • Resistance Exercise Reverses Aging in Human Skeletal Muscle

    Simon Melov;Mark A. Tarnopolsky;Kenneth Beckman;Krysta Felkey

  • Mitochondrial oxidative stress causes hyperphosphorylation of tau.

    Simon Melov;Paul A. Adlard;Karl Morten;Felicity Johnson

  • Genetic correction of Huntington's disease phenotypes in induced pluripotent stem cells.

    Mahru C. An;Ningzhe Zhang;Gary Scott;Daniel Montoro

  • Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice

    Adeel Safdar;Jacqueline M. Bourgeois;Daniel I. Ogborn;Jonathan P. Little

  • Massage Therapy Attenuates Inflammatory Signaling After Exercise-Induced Muscle Damage

    Justin D. Crane;Daniel I. Ogborn;Colleen Cupido;Simon Melov

  • SOD2 in mitochondrial dysfunction and neurodegeneration.

    James M. Flynn;Simon Melov

Frequent Co-Authors

Mark A. Tarnopolsky
Mark A. Tarnopolsky McMaster University
Judith Campisi
Judith Campisi Buck Institute for Research on Aging
Douglas C. Wallace
Douglas C. Wallace Children's Hospital of Philadelphia
Pankaj Kapahi
Pankaj Kapahi Buck Institute for Research on Aging
Gordon J. Lithgow
Gordon J. Lithgow Buck Institute for Research on Aging
Ashley I. Bush
Ashley I. Bush Florey Institute of Neuroscience and Mental Health
Brian K. Kennedy
Brian K. Kennedy National University of Singapore
David A. Bennett
David A. Bennett Rush University Medical Center
Philip L. De Jager
Philip L. De Jager Columbia University
Sean D. Mooney
Sean D. Mooney University of Washington

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