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D-Index & Metrics

Molecular Biology

D-Index
58
Citations
16377
World Ranking
2063
National Ranking
1028

Research.com Recognitions

  • 2002 - Member of the National Academy of Medicine (NAM)

Overview

James Hughes is affiliated with Emory University in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions to medicine. The main subfields of study include molecular biology, genetics, plant science, hematology, and cancer research.

Their work covers a range of topics, notably genomics and chromatin dynamics, RNA research and splicing, mechanisms of RNA and protein synthesis, epigenetics and DNA methylation, RNA modifications and cancer, genomics and phylogenetic studies, as well as single-cell and spatial transcriptomics.

James Hughes has published extensively in several well-known venues. Frequent publication venues include bioRxiv (Cold Spring Harbor Laboratory) with 23 publications, Nature Communications with 10, Blood with 7, Nature Genetics with 2, and Cell Stem Cell with 2.

Some of their recent papers are:

  • A blood atlas of COVID-19 defines hallmarks of disease severity and specificity, 2022, Cell
  • DeepC: predicting 3D genome folding using megabase-scale transfer learning, 2020, Nature Methods
  • Defining genome architecture at base-pair resolution, 2021, Nature
  • Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus, 2021, Nature Genetics
  • Loss of Extreme Long-Range Enhancers in Human Neural Crest Drives a Craniofacial Disorder, 2020, Cell Stem Cell

Frequent collaborators of James Hughes include Damien J. Downes, Douglas R. Higgs, A. Marieke Oudelaar, James Davies, and Jelena Telenius.

James Hughes was recognized as a Member of the National Academy of Medicine (NAM) in 2002.

Best Publications

  • Identification and characterization of the tuberous sclerosis gene on chromosome 16

    Mark Nellist;Bart Janssen;Phillip T. Brook-Carter;Arjenne L. W. Hesseling-Janssen

  • THE POLYCYSTIC KIDNEY-DISEASE-1 GENE ENCODES A 14-KB TRANSCRIPT AND LIES WITHIN A DUPLICATED REGION ON CHROMOSOME-16

    Christopher Ward;Belén Peral;Jim Hughes;Siep Thomas

  • The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains

    Unknown

  • Deletion of the TSC2 and PKD1 genes associated with severe infantile polycystic kidney disease - A contiguous gene syndrome

    Phillip T. Brook-Carter;Belén Peral;Christopher J. Ward;Peter Thompson

  • Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment.

    Jim R Hughes;Nigel Roberts;Simon McGowan;Deborah Hay

  • ATR-X Syndrome Protein Targets Tandem Repeats and Influences Allele-Specific Expression in a Size-Dependent Manner

    Martin J. Law;Karen M. Lower;Hsiao P.J. Voon;Jim R. Hughes

  • A Regulatory SNP Causes a Human Genetic Disease by Creating a New Transcriptional Promoter

    Marco De Gobbi;Vip Viprakasit;Jim R Hughes;Chris Fisher

  • Genetic dissection of the α-globin super-enhancer in vivo

    Deborah Hay;Jim R. Hughes;Christian Babbs;James O.J. Davies

  • A genome-editing strategy to treat β-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition

    Elizabeth A. Traxler;Elizabeth A. Traxler;Yu Yao;Yong Dong Wang;Kaitly J. Woodard

  • Intragenic Enhancers Act as Alternative Promoters

    Monika S. Kowalczyk;Jim R. Hughes;David Garrick;Magnus D. Lynch

  • Association between active genes occurs at nuclear speckles and is modulated by chromatin environment.

    Jill M. Brown;Joanne Green;Ricardo Pires das Neves;Helen A.C. Wallace

  • Multiplexed analysis of chromosome conformation at vastly improved sensitivity.

    James O J Davies;Jelena M Telenius;Simon J McGowan;Nigel A Roberts

  • Globin gene activation during haemopoiesis is driven by protein complexes nucleated by GATA-1 and GATA-2

    Eduardo Anguita;Jim Hughes;Clare M Heyworth;Gerd A Blobel

  • Manipulating the mouse genome to engineer precise functional syntenic replacements with human sequence.

    Helen A.C. Wallace;Fatima Marques-Kranc;Melville Richardson;Francisco Luna-Crespo

  • Genome-wide identification of TAL1's functional targets: Insights into its mechanisms of action in primary erythroid cells

    Mira T. Kassouf;Jim R. Hughes;Stephen Taylor;Simon J. McGowan

  • Unlinking an lncRNA from Its Associated cis Element

    Vikram R. Paralkar;Cristian C. Taborda;Peng Huang;Yu Yao

  • An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment

    Magnus D Lynch;Andrew J H Smith;Andrew J H Smith;Marco De Gobbi;Maria Flenley

  • Comparative Analysis of the Polycystic Kidney Disease 1 (PKD1) Gene Reveals an Integral Membrane Glycoprotein with Multiple Evolutionary Conserved Domains

    Richard Sandford;Barbara Sgotto;Sam Aparicio;Sydney Brenner

  • Tissue-specific CTCF-cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo.

    Lars L. P. Hanssen;Mira T. Kassouf;A. Marieke Oudelaar;Daniel Biggs

  • Annotation of cis-regulatory elements by identification, subclassification, and functional assessment of multispecies conserved sequences.

    Jim R. Hughes;Jan-Fang Cheng;Nicki Ventress;Shyam Prabhakar

Frequent Co-Authors

Douglas R. Higgs
Douglas R. Higgs University of Oxford
Richard J. Gibbons
Richard J. Gibbons University of Oxford
Jessica M. Sales
Jessica M. Sales Emory University
Veronica J. Buckle
Veronica J. Buckle University of Oxford
Ralph J. DiClemente
Ralph J. DiClemente New York University
Paul S. Weiss
Paul S. Weiss University of California, Los Angeles
William G. Wood
William G. Wood University of Oxford
William R. Jarvis
William R. Jarvis Centers for Disease Control and Prevention
Ross C. Hardison
Ross C. Hardison Pennsylvania State University
Simon J. McGowan
Simon J. McGowan University of Oxford

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