World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
88
Citations
28351
World Ranking
2702
National Ranking
1402

Medicine

D-Index
88
Citations
28376
World Ranking
13162
National Ranking
6712

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Stefan Somlo is affiliated with Yale University in the United States and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research is particularly focused on the genetics and molecular mechanisms underlying kidney diseases, with an emphasis on polycystic kidney disease and related conditions.

The main fields of study for Somlo include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

The subfields in which Somlo has published are:

  • Genetics
  • Molecular Biology
  • Pathology and Forensic Medicine
  • Cell Biology
  • Nephrology

Their work spans several important topics including:

  • Genetic and Kidney Cyst Diseases
  • Renal and related cancers
  • Biomedical Research and Pathophysiology
  • Microtubule and mitosis dynamics
  • Protist diversity and phylogeny
  • Genetic Syndromes and Imprinting
  • Fetal and Pediatric Neurological Disorders

Frequent publication venues for Somlo's research include:

  • Journal of the American Society of Nephrology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Kidney360
  • Nature Communications
  • Journal of Cell Science

Somlo has collaborated regularly with a number of researchers. Their most frequent co-authors include:

  • Ke Dong
  • Yiqiang Cai
  • Xin Tian
  • Whitney Besse
  • Michael Rehman

Significant recent publications by Stefan Somlo cover various aspects of kidney disease genetics and mechanisms:

  • Genetics in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference, 2022, Kidney International
  • Renal plasticity revealed through reversal of polycystic kidney disease in mice, 2021, Nature Genetics
  • Cyclin-Dependent Kinase 1 Activity Is a Driver of Cyst Growth in Polycystic Kidney Disease, 2020, Journal of the American Society of Nephrology
  • The C-terminal tail of polycystin-1 suppresses cystic disease in a mitochondrial enzyme-dependent fashion, 2023, Nature Communications
  • Disrupting polycystin-2 EF hand Ca2+ affinity does not alter channel function or contribute to polycystic kidney disease, 2020, Journal of Cell Science

Among honors received by Stefan Somlo is their membership in the Association of American Physicians, reflecting recognition within the medical research community.

Best Publications

  • PKD2, a Gene for Polycystic Kidney Disease That Encodes an Integral Membrane Protein

    Toshio Mochizuki;Guanqing Wu;Tomohito Hayashi;Stavroulla L. Xenophontos

  • Two Populations of Node Monocilia Initiate Left-Right Asymmetry in the Mouse

    James McGrath;Stefan Somlo;Svetlana Makova;Xin Tian

  • Polycystin-2 is an intracellular calcium release channel

    Peter Koulen;Yiqiang Cai;Lin Geng;Yoshiko Maeda

  • Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease

    Fangming Lin;Thomas Hiesberger;Kimberly Cordes;Angus M. Sinclair

  • PKD1 interacts with PKD2 through a probable coiled-coil domain

    Qian F;Germino Fj;Cai Y;Zhang X

  • Genetics and Pathogenesis of Polycystic Kidney Disease

    Peter Igarashi;Stefan Somlo

  • Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease.

    Vicente E Torres;Xiaofang Wang;Qi Qian;Stefan Somlo

  • PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like plexin-transcription-factor domains and parallel beta-helix 1 repeats

    Luiz F. Onuchic;Laszlo Furu;Yasuyuki Nagasawa;Xiaoying Hou

  • Somatic Inactivation of Pkd2 Results in Polycystic Kidney Disease

    Guanqing Wu;Vivette D'Agati;Yiqiang Cai;Glen Markowitz

  • DCDC2 is associated with reading disability and modulates neuronal development in the brain

    Haiying Meng;Shelley D. Smith;Karl Hager;Matthew Held

  • The Diagnosis and Prognosis of Autosomal Dominant Polycystic Kidney Disease

    P S Parfrey;J C Bear;J Morgan;B C Cramer

  • Identification and Characterization of Polycystin-2, the PKD2 Gene Product

    Yiqiang Cai;Yoshiko Maeda;Anna Cedzich;Vicente E. Torres

  • Cardiac defects and renal failure in mice with targeted mutations in Pkd2.

    Guanqing Wu;G. S. Markowitz;Li Li;V. D. D'agati

  • Epithelial-specific Cre/lox recombination in the developing kidney and genitourinary tract

    Xinli Shao;Stefan Somlo;Peter Igarashi

  • Autosomal dominant polycystic kidney disease: Localization of the second gene to chromosome 4q13–q23

    William J. Kimberling;Shrawan Kumar;Patricia A. Gabow;Judith B. Kenyon

  • Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1

    Sekiya Shibazaki;Zhiheng Yu;Saori Nishio;Xin Tian

  • Nerve growth cones isolated from fetal rat brain: subcellular fractionation and characterization.

    Karl H. Pfenninger;Leland Ellis;Marian P. Johnson;Linda B. Friedman

  • Getting a foothold in nephrotic syndrome.

    Stefan Somlo;Peter Mundel

  • Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia

    Vishal Patel;Ling Li;Patricia Cobo-Stark;Xinli Shao

  • Evidence for a third genetic locus for autosomal dominant polycystic kidney disease

    Martin C. Daoust;David M. Reynolds;Daniel G. Bichet;Stefan Somlo

Frequent Co-Authors

Gregory G. Germino
Gregory G. Germino National Institutes of Health
Peter Igarashi
Peter Igarashi University of Minnesota
Klaus Zerres
Klaus Zerres RWTH Aachen University
Michael J. Caplan
Michael J. Caplan Yale University
Peter C. Harris
Peter C. Harris Mayo Clinic
Stephen T. Reeders
Stephen T. Reeders Brigham and Women's Hospital
Glen S. Markowitz
Glen S. Markowitz Columbia University
Barbara E. Ehrlich
Barbara E. Ehrlich Yale University
Craig M. Crews
Craig M. Crews Yale University

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