Member of the Association of American Physicians
Gregory G. Germino spends much of his time researching PKD1, Autosomal dominant polycystic kidney disease, Cell biology, Polycystic kidney disease and Genetics. His work carried out in the field of PKD1 brings together such families of science as Apoptosis, Cancer research and Gene product. In his study, Endocrinology is strongly linked to Sirolimus, which falls under the umbrella field of Cancer research.
His Autosomal dominant polycystic kidney disease study deals with Cystic kidney intersecting with In utero, Regulation of gene expression, Kidney cysts and Physiology. His studies in Cell biology integrate themes in fields like Zebrafish, Cell cycle and Cell growth. His Polycystic kidney disease research is multidisciplinary, incorporating perspectives in TRPV4, Ion channel, Mechanosensitive channels, Calcium in biology and Molecular biology.
His primary scientific interests are in PKD1, Polycystic kidney disease, Autosomal dominant polycystic kidney disease, Genetics and Cell biology. Gregory G. Germino interconnects Cancer research, Gene product and Allele in the investigation of issues within PKD1. His Polycystic kidney disease study combines topics from a wide range of disciplines, such as Molecular biology and Bioinformatics.
Gregory G. Germino has researched Autosomal dominant polycystic kidney disease in several fields, including Cystic kidney and Kidney disease. His research in Cell biology intersects with topics in Cell cycle and Kidney development. His work deals with themes such as Polycystin 2 and Cleavage, Biochemistry, which intersect with Polycystin-1.
Gregory G. Germino mainly focuses on Polycystic kidney disease, PKD1, Autosomal dominant polycystic kidney disease, Cell biology and Internal medicine. His Polycystic kidney disease research incorporates themes from Kidney disease, Computational biology, Gerontology and Bioinformatics. His Autosomal dominant polycystic kidney disease study is concerned with the larger field of Cyst.
His Cell biology research incorporates elements of Phenotype, Cystic kidney and Kidney metabolism. The Internal medicine study which covers Endocrinology that intersects with Cancer research, Haploinsufficiency, Kidney development and Cell migration. His Cilium research is included under the broader classification of Genetics.
Cell biology, PKD1, Phenotype, Autosomal dominant polycystic kidney disease and Cilium are his primary areas of study. Gregory G. Germino has included themes like Polycystin complex, Ciliopathies, Kidney metabolism and Mature Centriole in his Cell biology study. PKD1 is a subfield of Polycystic kidney disease that he studies.
The study incorporates disciplines such as Cyst, Lipid metabolism and Lipidomics in addition to Polycystic kidney disease. Gregory G. Germino is investigating Endocrinology and Internal medicine as part of his examination of Autosomal dominant polycystic kidney disease. He combines subjects such as Transport protein, Cystic kidney, Wnt signaling pathway, Centriole and Centrosome with his study of Cilium.
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Multiple-laboratory comparison of microarray platforms
Rafael A Irizarry;Daniel Warren;Forrest Spencer;Irene F Kim.
Nature Methods (2005)
The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease.
Jonathan M. Shillingford;Noel S. Murcia;Claire H. Larson;Seng Hui Low.
Proceedings of the National Academy of Sciences of the United States of America (2006)
Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents
Kazushige Hanaoka;Feng Qian;Alessandra Boletta;Anil K. Bhunia.
PKD1 interacts with PKD2 through a probable coiled-coil domain
Qian F;Germino Fj;Cai Y;Zhang X.
Nature Genetics (1997)
The Molecular Basis of Focal Cyst Formation in Human Autosomal Dominant Polycystic Kidney Disease Type I
Feng Qian;Terry J Watnick;Luiz F Onuchic;Gregory G Germino.
PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like plexin-transcription-factor domains and parallel beta-helix 1 repeats
Luiz F. Onuchic;Laszlo Furu;Yasuyuki Nagasawa;Xiaoying Hou.
American Journal of Human Genetics (2002)
PKD1 Induces p21waf1 and Regulation of the Cell Cycle via Direct Activation of the JAK-STAT Signaling Pathway in a Process Requiring PKD2
Anil Kumar Bhunia;Klaus Piontek;Alessandra Boletta;Lijuan Liu.
A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1
Klaus Piontek;Luis F Menezes;Miguel A Garcia-Gonzalez;David L Huso.
Nature Medicine (2007)
TRPP2 and TRPV4 form a polymodal sensory channel complex
Michael Köttgen;Björn Buchholz;Miguel A. García-González;Fruzsina Kotsis.
Journal of Cell Biology (2008)
Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations
Feng Qian;Alessandra Boletta;Anil K. Bhunia;Hangxue Xu.
Proceedings of the National Academy of Sciences of the United States of America (2002)
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