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D-Index & Metrics

Biology and Biochemistry

D-Index
80
Citations
23686
World Ranking
4066
National Ranking
299

Overview

Gerd Walz is affiliated with the University of Freiburg in Germany and has contributed extensively to the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their research work primarily focuses on nephrology, molecular biology, and genetics, with significant publications addressing renal diseases and glomerulopathies, genetic and kidney cyst diseases, chronic kidney disease and diabetes, renal and related cancers, dialysis and renal disease management, COVID-19 clinical research studies, and renal transplantation outcomes and treatments.

They have published a substantial number of papers in key venues, including the Journal of the American Society of Nephrology, Kidney International, Nephrology Dialysis Transplantation, International Journal of Molecular Sciences, and Cell Reports.

Some of the recent papers authored in collaboration with other researchers include:

  • A molecular mechanism explaining albuminuria in kidney disease, 2020, Nature Metabolism
  • Genetic studies of urinary metabolites illuminate mechanisms of detoxification and excretion in humans, 2020, Nature Genetics
  • Frequent LPA KIV-2 Variants Lower Lipoprotein(a) Concentrations and Protect Against Coronary Artery Disease, 2021, Journal of the American College of Cardiology
  • The acetyltransferase p300 regulates NRF2 stability and localization, 2020, Biochemical and Biophysical Research Communications
  • CDC42 controlled apical-basal polarity regulates intestinal stem cell to transit amplifying cell fate transition via YAP-EGF-mTOR signaling, 2022, Cell Reports

Gerd Walz frequently collaborates with several colleagues in their research, including Matthias Schmid, Kai-Uwe Eckardt, Ulla T. Schultheiß, Fruzsina Kotsis, and Martin Helmstädter.

The scientist's publication record indicates a strong engagement with both clinical and molecular aspects of kidney-related diseases and genetic determinants underlying these conditions. Their cross-disciplinary research encompasses cellular polarity mechanisms, genetic metabolite studies, and molecular regulatory processes impacting renal function and cardiovascular risk factors.

Best Publications

  • The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease.

    Jonathan M. Shillingford;Noel S. Murcia;Claire H. Larson;Seng Hui Low

  • Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways

    Matias Simons;Joachim Gloy;Athina Ganner;Axel Bullerkotte

  • Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

    Björn Hartleben;Markus Gödel;Catherine Meyer-Schwesinger;Shuya Liu

  • The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4

    John A. Sayer;John A. Sayer;Edgar A. Otto;John F. O'Toole;Gudrun Nurnberg

  • Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination.

    Edgar A. Otto;Bernhard Schermer;Tomoko Obara;John F. O'Toole

  • Everolimus in patients with autosomal dominant polycystic kidney disease.

    Gerd Walz;Klemens Budde;Marwan Mannaa;Jens Nürnberger

  • Role of mTOR in podocyte function and diabetic nephropathy in humans and mice

    Markus Gödel;Björn Hartleben;Nadja Herbach;Shuya Liu

  • Interaction with Podocin Facilitates Nephrin Signaling

    Tobias B. Huber;Michael Köttgen;Birgit Schilling;Gerd Walz

  • Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling.

    Tobias B. Huber;Björn Hartleben;Jeong Kim;Miriam Schmidts

  • CD62/P-selectin recognition of myeloid and tumor cell sulfatides.

    Alejandro Aruffo;Alejandro Aruffo;Waldemar Kolanus;Gerd Walz;Pam Fredman

  • Exome Capture Reveals ZNF423 and CEP164 Mutations, Linking Renal Ciliopathies to DNA Damage Response Signaling

    Moumita Chaki;Rannar Airik;Amiya K. Ghosh;Rachel H. Giles

  • Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis

    Heike Olbrich;Manfred Fliegauf;Julia Hoefele;Andreas Kispert

  • TRPP2 and TRPV4 form a polymodal sensory channel complex

    Michael Köttgen;Björn Buchholz;Miguel A. García-González;Fruzsina Kotsis

  • Primary cilia regulate mTORC1 activity and cell size through Lkb1

    Christopher Boehlke;Fruzsina Kotsis;Vishal Patel;Simone Braeg

  • Loss of Nephrocystin-3 Function Can Cause Embryonic Lethality, Meckel-Gruber-like Syndrome, Situs Inversus, and Renal-Hepatic-Pancreatic Dysplasia

    Carsten Bergmann;Manfred Fliegauf;Nadina Ortiz Brüchle;Valeska Frank

  • Molecular basis of the functional podocin–nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains

    Tobias B. Huber;Matias Simons;Björn Hartleben;Leonie Sernetz

  • Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels.

    Tobias B. Huber;Bernhard Schermer;Roman Ulrich Müller;Martin Höhne

  • The Polycystic Kidney Disease 1 Gene Product Modulates Wnt Signaling

    Emily Kim;Thierry Arnould;Lorenz K. Sellin;Thomas Benzing

  • NEPH1 defines a novel family of podocin interacting proteins

    Lorenz Sellin;Tobias B. Huber;Peter Gerke;Ivo Quack

  • Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury

    Shuya Liu;Björn Hartleben;Oliver Kretz;Thorsten Wiech

Frequent Co-Authors

Tobias B. Huber
Tobias B. Huber Universität Hamburg
Thomas Benzing
Thomas Benzing University of Cologne
Friedhelm Hildebrandt
Friedhelm Hildebrandt Boston Children's Hospital
Bernhard Schermer
Bernhard Schermer University of Cologne
Kai-Uwe Eckardt
Kai-Uwe Eckardt Charité - University Medicine Berlin
Oliver Kretz
Oliver Kretz Universität Hamburg
Roland Nitschke
Roland Nitschke University of Freiburg
Dontscho Kerjaschki
Dontscho Kerjaschki Medical University of Vienna
Anna Köttgen
Anna Köttgen University of Freiburg
Edgar A. Otto
Edgar A. Otto University of Michigan–Ann Arbor

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