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Genetics

D-Index
87
Citations
23810
World Ranking
1220
National Ranking
580

Medicine

D-Index
89
Citations
25091
World Ranking
12821
National Ranking
6553

Overview

Edgar A. Otto is affiliated with the University of Michigan-Ann Arbor in the United States. Their research primarily focuses on medicine, with significant contributions in biochemistry, genetics, and molecular biology. Otto's work spans several subfields including nephrology, molecular biology, genetics, pulmonary and respiratory medicine, and pediatrics, perinatology, and child health.

The scientist has contributed extensively to topics related to chronic kidney disease and diabetes, single-cell and spatial transcriptomics, renal and related cancers, renal diseases and glomerulopathies, genetic and kidney cyst diseases, organ donation and transplantation, and diabetes and associated disorders.

Frequent coauthors who have collaborated with Otto include Rajasree Menon, Matthias Kretzler, Abhijit S. Naik, Jeffrey B. Hodgin, and Viji Nair.

Otto's work has appeared predominantly in the following venues:

  • Journal of the American Society of Nephrology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Clinical Investigation
  • Kidney International
  • UNC Libraries

Some notable recent papers authored or coauthored by Edgar A. Otto include:

  • An atlas of healthy and injured cell states and niches in the human kidney, 2023, Nature
  • Single cell transcriptomics identifies focal segmental glomerulosclerosis remission endothelial biomarker, 2020, JCI Insight
  • A reference tissue atlas for the human kidney, 2022, Science Advances
  • An atlas of healthy and injured cell states and niches in the human kidney, 2021, bioRxiv (Cold Spring Harbor Laboratory)
  • SGLT2 inhibitors mitigate kidney tubular metabolic and mTORC1 perturbations in youth-onset type 2 diabetes, 2023, Journal of Clinical Investigation

Best Publications

  • The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4

    John A. Sayer;John A. Sayer;Edgar A. Otto;John F. O'Toole;Gudrun Nurnberg

  • Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination.

    Edgar A. Otto;Bernhard Schermer;Tomoko Obara;John F. O'Toole

  • A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition

    Francesc R Garcia-Gonzalo;Kevin C Corbit;María Salomé Sirerol-Piquer;Gokul Ramaswami

  • Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible.

    Bernward Hinkes;Roger C. Wiggins;Rasheed Gbadegesin;Christopher N. Vlangos

  • Mapping the NPHP-JBTS-MKS Protein Network Reveals Ciliopathy Disease Genes and Pathways

    Liyun Sang;Julie J. Miller;Kevin C. Corbit;Rachel H. Giles

  • Barttin is a Cl- channel beta-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion.

    Raúl Estévez;Thomas Boettger;Valentin Stein;Ralf Birkenhäger

  • Mutation of BSND causes Bartter syndrome with sensorineural deafness and kidney failure.

    Ralf Birkenhäger;Edgar Otto;Maria J. Schürmann;Martin Vollmer

  • SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes.

    Rainer G. Ruf;Pin-Xian Xu;Derek Silvius;Edgar A. Otto

  • Nephrocystin-5, a ciliary IQ domain protein, is mutated in Senior-Loken syndrome and interacts with RPGR and calmodulin

    Edgar A. Otto;Bart Loeys;Hemant Khanna;Jan Hellemans

  • Nephronophthisis: Disease Mechanisms of a Ciliopathy

    Friedhelm Hildebrandt;Massimo Attanasio;Edgar Otto

  • Exome Capture Reveals ZNF423 and CEP164 Mutations, Linking Renal Ciliopathies to DNA Damage Response Signaling

    Moumita Chaki;Rannar Airik;Amiya K. Ghosh;Rachel H. Giles

  • Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis

    Heike Olbrich;Manfred Fliegauf;Julia Hoefele;Andreas Kispert

  • In-frame deletion in a novel centrosomal/ciliary protein CEP290/NPHP6 perturbs its interaction with RPGR and results in early-onset retinal degeneration in the rd16 mouse

    Bo Chang;Hemant Khanna;Norman Hawes;David Jimeno

  • Mutations in the Cilia Gene ARL13B Lead to the Classical Form of Joubert Syndrome

    Vincent Cantagrel;Jennifer L. Silhavy;Stephanie L. Bielas;Dominika Swistun

  • TTC21B contributes both causal and modifying alleles across the ciliopathy spectrum

    Erica E. Davis;Qi Zhang;Qin Liu;Bill H. Diplas

  • A novel gene encoding an SH3 domain protein is mutated in nephronophthisis type 1

    Friedhelm Hildebrandt;Edgar Otto;Cornelia Rensing;Hans Gerd Nothwang

  • High-Throughput Screening Enhances Kidney Organoid Differentiation From Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping

    Stefan M. Czerniecki;Nelly M. Cruz;Jennifer L. Harder;Rajasree Menon

  • Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy

    Edgar A Otto;Toby W Hurd;Rannar Airik;Moumita Chaki

  • ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption

    Shazia Ashraf;Heon Yung Gee;Stephanie Woerner;Stephanie Woerner;Letian X. Xie

  • Cilia and centrosomes: a unifying pathogenic concept for cystic kidney disease?

    Friedhelm Hildebrandt;Edgar Otto

Frequent Co-Authors

Friedhelm Hildebrandt
Friedhelm Hildebrandt Boston Children's Hospital
Heon Yung Gee
Heon Yung Gee Yonsei University
Nicholas Katsanis
Nicholas Katsanis Galatea Bio Inc
Sophie Saunier
Sophie Saunier Université Paris Cité
Erica E. Davis
Erica E. Davis Lurie Children's Hospital
Corinne Antignac
Corinne Antignac Institut Imagine
George J. Kahaly
George J. Kahaly Johannes Gutenberg University of Mainz
Heymut Omran
Heymut Omran University of Münster
Richard P. Lifton
Richard P. Lifton Rockefeller University
Gudrun Nürnberg
Gudrun Nürnberg University of Cologne

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