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Biology and Biochemistry
Germany
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
120
Citations
47971
World Ranking
650
National Ranking
48

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2025 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2023 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2004 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Biochemistry and Biophysics
  • 2000 - Member of Academia Europaea
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Thomas J. Jentsch is affiliated with Charité - University Medicine Berlin in Germany. Their research spans multiple fields, primarily focusing on biochemistry, genetics, molecular biology, and medicine. Their work also covers significant subfields including molecular biology, physiology, cardiology and cardiovascular medicine, cell biology, and cellular and molecular neuroscience.

The scientist's research topics include:

  • Ion channel regulation and function
  • Calcium signaling and nucleotide metabolism
  • Cellular transport and secretion
  • Neuroscience and neuropharmacology research
  • Ion transport and channel regulation
  • Cardiac electrophysiology and arrhythmias
  • Erythrocyte function and pathophysiology

Thomas J. Jentsch has published in a variety of frequent publication venues. The most common include:

  • Journal of Biological Chemistry
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Clinical Investigation
  • The American Journal of Human Genetics
  • Science Advances

Recent notable papers authored by Thomas J. Jentsch include:

  • "Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity" (2020, Immunity)
  • "Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation" (2020, Communications Biology)
  • "Proton-gated anion transport governs macropinosome shrinkage" (2022, Nature Cell Biology)
  • "Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration" (2020, The EMBO Journal)
  • "Unique variants in CLCN3, encoding an endosomal anion/proton exchanger, underlie a spectrum of neurodevelopmental disorders" (2021, The American Journal of Human Genetics)

Frequent collaborators in Thomas J. Jentsch's research include:

  • Maya M. Polovitskaya
  • Rosa Planells-Cases
  • Karen I. López-Cayuqueo
  • Richard K. Hite
  • Mariia Zeziulia

Thomas J. Jentsch has been recognized with several distinctions including membership in notable scientific organizations. Honors include:

  • German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina - Nationale Akademie der Wissenschaften (2004), recognized for work in biochemistry and biophysics
  • Member of Academia Europaea (2000)
  • Member of the European Molecular Biology Organization (EMBO)

Best Publications

  • Molecular Structure and Physiological Function of Chloride Channels

    Thomas J. Jentsch;Valentin Stein;Frank Weinreich;Anselm A. Zdebik

  • A Potassium Channel Mutation in Neonatal Human Epilepsy

    Christian Biervert;Björn C. Schroeder;Björn C. Schroeder;Björn C. Schroeder;Christian Kubisch;Christian Kubisch;Christian Kubisch;Samuel F. Berkovic;Samuel F. Berkovic;Samuel F. Berkovic

  • Neuronal KCNQ potassium channels: physiology and role in disease.

    Thomas J. Jentsch

  • Loss of the ClC-7 Chloride Channel Leads to Osteopetrosis in Mice and Man

    Uwe Kornak;Dagmar Kasper;Michael R Bösl;Edelgard Kaiser

  • KCNQ4, a Novel Potassium Channel Expressed in Sensory Outer Hair Cells, Is Mutated in Dominant Deafness

    Christian Kubisch;Björn C Schroeder;Thomas Friedrich;Björn Lütjohann

  • The skeletal muscle chloride channel in dominant and recessive human myotonia.

    Manuela C. Koch;Klaus Steinmeyer;Claudius Lorenz;Kenneth Ricker

  • A common molecular basis for three inherited kidney stone diseases

    Sarah E. Lloyd;Simon H. S. Pearce;Simon E. Fisher;Klaus Steinmeyer

  • ClC-5 Cl - -channel disruption impairs endocytosis in a mouse model for Dent's disease

    Nils Piwon;Willy Günther;Michael Schwake;Michael R. Bösl

  • Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K + channels causes epilepsy

    Björn C. Schroeder;Christian Kubisch;Valentin Stein;Thomas J. Jentsch

  • Disruption of KCC2 Reveals an Essential Role of K-Cl Cotransport Already in Early Synaptic Inhibition

    Christian A. Hübner;Valentin Stein;Irm Hermans-Borgmeyer;Torsten Meyer

  • Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes.

    Thomas J. Jentsch;Klaus Steinmeyer;Gisela Schwarz

  • A constitutively open potassium channel formed by KCNQ1 and KCNE3

    Björn C. Schroeder;Siegfried Waldegger;Susanne Fehr;Markus Bleich

  • A chloride channel widely expressed in epithelial and non-epithelial cells.

    Astrid Thiemann;Stefan Gründer;Michael Pusch;Thomas J. Jentsch

  • Voltage-dependent electrogenic chloride/proton exchange by endosomal CLC proteins.

    Olaf Scheel;Anselm A. Zdebik;Stéphane Lourdel;Thomas J. Jentsch

  • Barttin is a Cl- channel beta-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion.

    Raúl Estévez;Thomas Boettger;Valentin Stein;Ralf Birkenhäger

  • ClC-5, the chloride channel mutated in Dent’s disease, colocalizes with the proton pump in endocytotically active kidney cells

    Willy Günther;Anke Lüchow;Françoise Cluzeaud;Alain Vandewalle

  • Disruption of ClC-3, a Chloride Channel Expressed on Synaptic Vesicles, Leads to a Loss of the Hippocampus

    Sandra M. Stobrawa;Tilman Breiderhoff;Shigeo Takamori;Dominique Engel

  • Identification of LRRC8 Heteromers as an Essential Component of the Volume-Regulated Anion Channel VRAC

    Felizia K. Voss;Felizia K. Voss;Florian Ullrich;Florian Ullrich;Jonas Münch;Jonas Münch;Katina Lazarow

  • Primary structure and functional expression of a developmentally regulated skeletal muscle chloride channel.

    Klaus Steinmeyer;Christoph Ortland;Thomas J. Jentsch

  • KCNQ5, a Novel Potassium Channel Broadly Expressed in Brain, Mediates M-type Currents

    Björn C. Schroeder;Mirko Hechenberger;Frank Weinreich;Christian Kubisch

Frequent Co-Authors

Michael Pusch
Michael Pusch National Research Council (CNR)
Christian A. Hübner
Christian A. Hübner Friedrich Schiller University Jena
Uwe Kornak
Uwe Kornak University of Göttingen
Christian Kubisch
Christian Kubisch Universität Hamburg
Michaela Schweizer
Michaela Schweizer Universität Hamburg
Uwe Ludewig
Uwe Ludewig University of Hohenheim
Rajesh V. Thakker
Rajesh V. Thakker University of Oxford
Chris I. De Zeeuw
Chris I. De Zeeuw Erasmus University Rotterdam
Eric Haan
Eric Haan University of Adelaide

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