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D-Index & Metrics

Biology and Biochemistry

D-Index
55
Citations
9324
World Ranking
15208
National Ranking
1077

Overview

Christoph Fahlke is affiliated with the Forschungszentrum Jülich in Germany. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with a substantial focus on Neuroscience. Within these disciplines, Fahlke has contributed notably to Molecular Biology and Cellular and Molecular Neuroscience, as well as Spectroscopy, Biochemistry, and Genetics.

The scientist's work investigates several main topics, including Neuroscience and Neuropharmacology Research and Ion channel regulation and function. Other significant areas of study include Molecular Sensors and Ion Detection, Photoreceptor and Optogenetics research, Lipid Membrane Structure and Behavior, Amino Acid Enzymes and Metabolism, and Epilepsy research and treatment.

Fahlke's frequent co-authors highlight collaborative efforts with Daniel Kortzak, Peter Kovermann, Stefanie Bungert-Plümke, Raul E. Guzman, and Jan-Philipp Machtens. These collaborations have supported research published in various academic venues.

Regarding publication venues, Fahlke has consistently published in bioRxiv (Cold Spring Harbor Laboratory), Frontiers in Cellular Neuroscience, Frontiers in Physiology, Human Mutation, and Zenodo (CERN European Organization for Nuclear Research).

Notable recent papers include:

  • Dysregulation of Astrocyte Ion Homeostasis and Its Relevance for Stroke-Induced Brain Damage, 2021, International Journal of Molecular Sciences
  • Functional consequences of SLC1A3 mutations associated with episodic ataxia 6, 2020, Human Mutation
  • Increased glutamate transporter-associated anion currents cause glial apoptosis in episodic ataxia 6, 2020, Brain Communications
  • Molecular Basis of CLC Antiporter Inhibition by Fluoride, 2020, Journal of the American Chemical Society
  • Vesicular glutamate transporters are H+-anion exchangers that operate at variable stoichiometry, 2023, Nature Communications

Best Publications

  • Engaging neuroscience to advance translational research in brain barrier biology

    Edward A. Neuwelt;Björn Bauer;Christoph Fahlke;Gert Fricker

  • Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism

    Ute I Scholl;Gerald Goh;Gabriel Stölting;Regina Campos de Oliveira

  • Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies

    Karsten Haug;Maike Warnstedt;Alexi K Alekov;Thomas Sander

  • Recurrent gain of function mutation in calcium channel CACNA1H causes early-onset hypertension with primary aldosteronism

    Ute I Scholl;Gabriel Stölting;Carol Nelson-Williams;Alfred A Vichot

  • CLCN2 chloride channel mutations in familial hyperaldosteronism type II

    Ute I. Scholl;Ute I. Scholl;Gabriel Stölting;Julia Schewe;Anne Thiel

  • Pore-forming segments in voltage-gated chloride channels

    Christoph Fahlke;Henry T. Yu;Carol L. Beck;Thomas H. Rhodes

  • Crystal structure of a light-driven sodium pump

    Ivan Yu. Gushchin;Vitaly Shevchenko;Vitaly Shevchenko;Vitaly Polovinkin;Kirill Kovalev

  • The Concise Guide to PHARMACOLOGY 2013/14: overview

    Stephen P.H. Alexander;Helen E. Benson;Elena Faccenda;Adam J. Pawson

  • Molecular basis for decreased muscle chloride conductance in the myotonic goat.

    Carol L. Beck;Christoph Fahlke;Alfred L. George

  • Ion permeation and selectivity in ClC-type chloride channels.

    Christoph Fahlke

  • Mechanisms of anion conduction by coupled glutamate transporters.

    Jan-Philipp Machtens;Jan-Philipp Machtens;Jan-Philipp Machtens;Daniel Kortzak;Christine Lansche;Ariane Leinenweber

  • A mutation in autosomal dominant myotonia congenita affects pore properties of the muscle chloride channel

    Christoph Fahlke;Carol L. Beck;Alfred L. George

  • An Aspartic Acid Residue Important for Voltage-Dependent Gating of Human Muscle Chloride Channels

    Christoph Fahlke;Reinhardt Riidel;Nenad Mitrovic;Ming Zhou

  • A Trimeric Quaternary Structure Is Conserved in Bacterial and Human Glutamate Transporters

    Sandra Gendreau;Stephan Voswinkel;Delany Torres-Salazar;Niklas Lang

  • Different effects on gating of three myotonia-causing mutations in the inactivation gate of the human muscle sodium channel.

    N Mitrovié;A L George;H Lerche;S Wagner

  • Barttin modulates trafficking and function of ClC-K channels

    Ute Scholl;Simon Hebeisen;Audrey G. H. Janssen;Gerhard Müller-Newen

  • CLC channel function and dysfunction in health and disease

    Gabriel Stölting;Martin Fischer;Christoph Fahlke

  • The photophysics of LOV-based fluorescent proteins – new tools for cell biology

    Marcus Wingen;Janko Potzkei;Stephan Endres;Giorgia Casini

  • A β-Lactam Antibiotic Dampens Excitotoxic Inflammatory CNS Damage in a Mouse Model of Multiple Sclerosis

    Nico Melzer;Sven G. Meuth;Delany Torres-Salazar;Delany Torres-Salazar;Stefan Bittner

  • CLCN2 chloride channel mutations in familial hyperaldosteronism type II

    Scholl Ui;Stölting G;Schewe J;Thiel A

Frequent Co-Authors

Alfred L. George
Alfred L. George Northwestern University
Richard P. Lifton
Richard P. Lifton Rockefeller University
Murim Choi
Murim Choi Seoul National University
Gerhard Müller-Newen
Gerhard Müller-Newen RWTH Aachen University
Bert L. de Groot
Bert L. de Groot Max Planck Society
Günther Schmalzing
Günther Schmalzing RWTH Aachen University
Christine R. Rose
Christine R. Rose Heinrich Heine University Düsseldorf
Thomas Sander
Thomas Sander University of Cologne
Ernst Bamberg
Ernst Bamberg Max Planck Society
Frank Lehmann-Horn
Frank Lehmann-Horn University of Ulm

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