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Günther Schmalzing

Günther Schmalzing

D-Index & Metrics

Biology and Biochemistry

D-Index
55
Citations
8174
World Ranking
15294
National Ranking
1082

Overview

Günther Schmalzing is affiliated with RWTH Aachen University in Germany and focuses their research primarily within the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their work spans several subfields including Physiology, Molecular Biology, Psychiatry and Mental Health, Endocrine and Autonomic Systems, and Pharmacology.

The scientist's research addresses key topics such as Adenosine and Purinergic Signaling, Receptor Mechanisms and Signaling, Ion Channel Regulation and Function, Pharmacological Receptor Mechanisms and Effects, Cancer, Stress, Anesthesia, and Immune Response, Neuroscience of Respiration and Sleep, and Pain Mechanisms and Treatments.

Günther Schmalzing has published papers in various academic journals, with frequent contributions to Frontiers in Pharmacology, British Journal of Pharmacology, ACS Chemical Neuroscience, World Journal of Traditional Chinese Medicine, and Purinergic Signalling.

Selected recent publications include:

  • Swarm Learning for decentralized and confidential clinical machine learning, 2021, Nature
  • Update of P2X receptor properties and their pharmacology: IUPHAR Review 30, 2020, British Journal of Pharmacology
  • Gallic Acid Improves Comorbid Chronic Pain and Depression Behaviors by Inhibiting P2X7 Receptor-Mediated Ferroptosis in the Spinal Cord of Rats, 2023, ACS Chemical Neuroscience
  • Dissection of P2X4 and P2X7 Receptor Current Components in BV-2 Microglia, 2020, International Journal of Molecular Sciences
  • Gallic Acid Alleviates Neuropathic Pain Behaviors in Rats by Inhibiting P2X7 Receptor-Mediated NF-κB/STAT3 Signaling Pathway, 2021, Frontiers in Pharmacology

The scientist frequently collaborates with co-authors including Ralf Hausmann, Runan Yang, Hong Nie, Shangdong Liang, and Jannis Körner, with the number of joint publications ranging from five to seven for these collaborators.

Best Publications

  • P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand-gated ion channels.

    Annette Nicke;Hans G. Bäumert;Jürgen Rettinger;Annette Eichele

  • Update of P2X receptor properties and their pharmacology: IUPHAR Review 30

    Peter Illes;Peter Illes;Christa E. Müller;Kenneth A. Jacobson;Thomas Grutter

  • Molecular characterization of human and bovine endothelin converting enzyme (ECE‐1)

    Martin Schmidt;Burkhard Kröger;Elard Jacob;Harald Seulberger

  • The Elusive P2X7 Macropore

    Francesco Di Virgilio;Günther Schmalzing;Fritz Markwardt

  • Trophic activity of a naturally occurring truncated isoform of the P2X7 receptor

    Elena Adinolfi;Maria Cirillo;Ronja Woltersdorf;Simonetta Falzoni

  • Molecular determinants of glycine receptor subunit assembly.

    Nathalie Griffon;Cora Büttner;Annette Nicke;Jochen Kuhse

  • Activation of protein kinase C by phorbol ester induces downregulation of the Na+/K(+)-ATPase in oocytes of Xenopus laevis.

    Larisa A. Vasilets;Günther Schmalzing;Kristin Mädefessel;Winfried Haase

  • Trimeric Architecture of Homomeric P2X2 and Heteromeric P2X1+2 Receptor Subtypes

    Armaz Aschrafi;Sven Sadtler;Cristina Niculescu;Jürgen Rettinger

  • The adhesion molecule on glia (AMOG/beta 2) and alpha 1 subunits assemble to functional sodium pumps in Xenopus oocytes.

    Günther Schmalzing;Silke Kröner;Melitta Schachner;Sergio Gloor

  • TMEM16A(a)/anoctamin-1 Shares a Homodimeric Architecture with CLC Chloride Channels

    Ghada Fallah;Thomas Römer;Silvia Detro-Dassen;Ursula Braam

  • Ubiquitination Precedes Internalization and Proteolytic Cleavage of Plasma Membrane-bound Glycine Receptors

    Cora Büttner;Sven Sadtler;Anne Leyendecker;Bodo Laube

  • A Trimeric Quaternary Structure Is Conserved in Bacterial and Human Glutamate Transporters

    Sandra Gendreau;Stephan Voswinkel;Delany Torres-Salazar;Niklas Lang

  • A Novel C3-like ADP-ribosyltransferase fromStaphylococcus aureus Modifying RhoE and Rnd3

    Christian Wilde;Gursgaran S. Chhatwal;Günther Schmalzing;Klaus Aktories

  • NF546 [4,4′-(Carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-α,α′-diphosphonic Acid) Tetrasodium Salt] Is a Non-Nucleotide P2Y11 Agonist and Stimulates Release of Interleukin-8 from Human Monocyte-Derived Dendritic Cells

    Sabine Meis;Alexandra Hamacher;Darunee Hongwiset;Claudia Marzian

  • Positive allosteric modulation by ivermectin of human but not murine P2X7 receptors.

    W Nörenberg;H Sobottka;C Hempel;T Plötz

  • Activation and Desensitization of the Recombinant P2X1 Receptor at Nanomolar ATP Concentrations

    Jürgen Rettinger;Günther Schmalzing

  • Synthesis and Structure−Activity Relationships of Suramin-Derived P2Y11 Receptor Antagonists with Nanomolar Potency

    Heiko Ullmann;Sabine Meis;Darunee Hongwiset;Claudia Marzian

  • The suramin analogue NF279 is a novel and potent antagonist selective for the P2X1 receptor

    Jürgen Rettinger;Günther Schmalzing;Susanne Damer;Gregor Müller

  • Desensitization masks nanomolar potency of ATP for the P2X1 receptor.

    Juergen Rettinger;Günther Schmalzing

  • Conserved Dimeric Subunit Stoichiometry of SLC26 Multifunctional Anion Exchangers

    Silvia Detro-Dassen;Michael Schänzler;Heike Lauks;Ina Martin

Frequent Co-Authors

Bodo Laube
Bodo Laube Technical University of Darmstadt
Heinrich Betz
Heinrich Betz Max Planck Society
Matthias U. Kassack
Matthias U. Kassack Heinrich Heine University Düsseldorf
Christa E. Müller
Christa E. Müller University of Bonn
Christoph Fahlke
Christoph Fahlke Forschungszentrum Jülich
J. Michael McIntosh
J. Michael McIntosh University of Utah
Francesco Di Virgilio
Francesco Di Virgilio University of Ferrara
Gerhard Müller-Newen
Gerhard Müller-Newen RWTH Aachen University
Jean-Marie Boeynaems
Jean-Marie Boeynaems Université Libre de Bruxelles
Michael Wiese
Michael Wiese University of Bonn

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