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D-Index & Metrics

Biology and Biochemistry

D-Index
46
Citations
10497
World Ranking
18860
National Ranking
1293

Overview

Bodo Laube is affiliated with the Technical University of Darmstadt in Germany. Their research predominantly focuses on biochemistry, genetics, molecular biology, and neuroscience. These fields encompass several specialized subfields including molecular biology, cellular and molecular neuroscience, physiology, cognitive neuroscience, and physical and theoretical chemistry.

The scientist's recent publications reflect a diverse interest in receptor mechanisms, ion channel regulation, and neuropharmacology. Notable papers include:

  • "Thermophoretic analysis of ligand-specific conformational states of the inhibitory glycine receptor embedded in copolymer nanodiscs" (2020, Scientific Reports)
  • "APP fragment controls both ionotropic and non-ionotropic signaling of NMDA receptors" (2024, Neuron)
  • "Analysis of M4 Transmembrane Segments in NMDA Receptor Function: A Negative Allosteric Modulatory Site at the GluN1 M4 is Determining the Efficiency of Neurosteroid Modulation" (2021, Frontiers in Pharmacology)
  • "Analysis of M4 transmembrane domains in NMDA receptor function: a negative allosteric modulation site at the GluN1 M4 is determining the efficiency of neurosteroid modulation" (2021, bioRxiv (Cold Spring Harbor Laboratory))
  • "Gating the channel pore of ionotropic glutamate receptors with bacterial substrate binding proteins" (2021, bioRxiv (Cold Spring Harbor Laboratory))

The main topics covered in Laube's body of work include:

  • Neuroscience and neuropharmacology research
  • Ion channel regulation and function
  • Nicotinic acetylcholine receptors study
  • Receptor mechanisms and signaling
  • Alzheimer's disease research and treatments
  • Memory and neural mechanisms
  • Thermodynamics and calorimetric analyses

Frequent collaborators in their research include Max Bernhard, Jade Dunot, Sébastien Moreno, Carine Gandin, and Paula A. Pousinha.

Laube has published extensively in several venues, with the most common being:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neuron
  • Scientific Reports
  • Frontiers in Pharmacology
  • SSRN Electronic Journal

Best Publications

  • Evidence for a Tetrameric Structure of Recombinant NMDA Receptors

    Bodo Laube;Jochen Kuhse;Heinrich Betz

  • Molecular determinants of agonist discrimination by NMDA receptor subunits: analysis of the glutamate binding site on the NR2B subunit.

    Bodo Laube;Hirokazu Hirai;Mike Sturgess;Heinrich Betz

  • Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes.

    Sabine Endele;Georg Rosenberger;Kirsten Geider;Bernt Popp

  • Mutational analysis of the glycine-binding site of the NMDA receptor: Structural similarity with bacterial amino acid-binding proteins

    Alexander Kuryatov;Bodo Laube;Heinrich Betz;Jochen Kuhse

  • Loss of Postsynaptic GABAA Receptor Clustering in Gephyrin-Deficient Mice

    Matthias Kneussel;Johann Helmut Brandstätter;Bodo Laube;Sabine Stahl

  • Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes

    Johannes R Lemke;Dennis Lal;Eva M Reinthaler;Isabelle Steiner

  • The β Subunit Determines the Ligand Binding Properties of Synaptic Glycine Receptors

    Joanna Grudzinska;Rudolf Schemm;Svenja Haeger;Annette Nicke

  • Glycine receptors: recent insights into their structural organization and functional diversity.

    Heinrich Betz;Bodo Laube

  • Deletion of the Mouse Glycine Transporter 2 Results in a Hyperekplexia Phenotype and Postnatal Lethality

    Jesús Gomeza;Koji Ohno;Swen Hülsmann;Wencke Armsen

  • The glycine binding site of the N-methyl-D-aspartate receptor subunit NR1: identification of novel determinants of co-agonist potentiation in the extracellular M3-M4 loop region

    Hirokazu Hirai;Joachim Kirsch;Bodo Laube;Heinrich Betz

  • Modulation of glycine receptor function: a novel approach for therapeutic intervention at inhibitory synapses?

    Bodo Laube;Gábor Maksay;Rudolf Schemm;Heinrich Betz

  • GRIN2B encephalopathy: Novel findings on phenotype, variant clustering, functional consequences and treatment aspects

    Konrad Platzer;Hongjie Yuan;Hannah Schütz;Alexander Winschel

  • Modulation by zinc ions of native rat and recombinant human inhibitory glycine receptors.

    Bodo Laube;J. Kuhse;N. Rundström;J. Kirsch

  • GRIN2B mutations in West syndrome and intellectual disability with focal epilepsy.

    Johannes R Lemke;Rik Hendrickx;Kirsten Geider;Bodo Laube

  • Assembly of the inhibitory glycine receptor: identification of amino acid sequence motifs governing subunit stoichiometry.

    J. Kuhse;Bodo Laube;D. Magalei;H. Betz

  • Impaired GABAergic transmission and altered hippocampal synaptic plasticity in collybistin‐deficient mice

    Theofilos Papadopoulos;Martin Korte;Volker Eulenburg;Hisahiko Kubota

  • Delineating the GRIN1 phenotypic spectrum: A distinct genetic NMDA receptor encephalopathy

    Johannes R. Lemke;Kirsten Geider;Katherine L. Helbig;Henrike O. Heyne

  • Decreased agonist affinity and chloride conductance of mutant glycine receptors associated with human hereditary hyperekplexia.

    D. Langosch;Bodo Laube;N. Rundström;V. Schmieden

  • Molecular cloning and functional expression of a novel rat heart P2X purinoceptor.

    Miguel Garcia-Guzman;Florentina Soto;Bodo Laube;Walter Stühmer

  • Hyperekplexia Phenotype of Glycine Receptor α1 Subunit Mutant Mice Identifies Zn2+ as an Essential Endogenous Modulator of Glycinergic Neurotransmission

    Klaus Hirzel;Ulrike Müller;A. Tobias Latal;Swen Hülsmann

Frequent Co-Authors

Heinrich Betz
Heinrich Betz Max Planck Society
Günther Schmalzing
Günther Schmalzing RWTH Aachen University
Robert J. Harvey
Robert J. Harvey University of the Sunshine Coast
Rikke S. Møller
Rikke S. Møller University of Southern Denmark
Christel Depienne
Christel Depienne Essen University Hospital
Sarah Weckhuysen
Sarah Weckhuysen University of Antwerp
Katherine L. Helbig
Katherine L. Helbig Children's Hospital of Philadelphia
Hirokazu Hirai
Hirokazu Hirai Gunma University
Anna-Elina Lehesjoki
Anna-Elina Lehesjoki University of Helsinki
William B. Dobyns
William B. Dobyns University of Minnesota

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