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Biology and Biochemistry

D-Index
84
Citations
23501
World Ranking
3347
National Ranking
253

Research.com Recognitions

  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom

Overview

Trevor G. Smart is affiliated with University College London in the United Kingdom. Their research primarily focuses on the intersection of biochemistry, genetics, molecular biology, and neuroscience. The scientist has contributed extensively to subfields such as molecular biology and cellular and molecular neuroscience, with additional work relating to materials chemistry, neurology, and biochemistry.

The main topics covered by their research include:

  • Neuroscience and neuropharmacology research
  • Receptor mechanisms and signaling
  • Ion channel regulation and function
  • Nicotinic acetylcholine receptors study
  • Pharmacological receptor mechanisms and effects
  • Signaling pathways in disease
  • Retinal development and disorders

Trevor G. Smart has published in several venues, with frequent contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neuropharmacology
  • IUPHAR/BPS Guide to Pharmacology CITE
  • British Journal of Pharmacology
  • Nature

Their recent papers include:

  • THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels, 2021, British Journal of Pharmacology
  • The Concise Guide to PHARMACOLOGY 2023/24: Ion channels, 2023, British Journal of Pharmacology
  • Mechanisms of inhibition and activation of extrasynaptic αβ GABAA receptors, 2022, Nature
  • Physiological role for GABAA receptor desensitization in the induction of long-term potentiation at inhibitory synapses, 2021, Nature Communications
  • Structural determinants and regulation of spontaneous activity in GABAA receptors, 2021, Nature Communications

Frequent collaborators in Trevor G. Smart's work include:

  • Martin Mortensen
  • Saad Hannan
  • Joseph W. Lynch
  • Lucia G. Sivilotti
  • John A. Peters

Trevor G. Smart has received recognition as a Fellow of The Academy of Medical Sciences, United Kingdom.

Best Publications

  • Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites.

    Alastair M. Hosie;Megan E. Wilkins;Helena M. A. da Silva;Trevor G. Smart

  • HEK293 cell line: A vehicle for the expression of recombinant proteins

    Philip Thomas;Trevor G. Smart

  • GlyR alpha3: an essential target for spinal PGE2-mediated inflammatory pain sensitization.

    Robert J. Harvey;Ulrike B. Depner;Heinz Wässle;Seifollah Ahmadi

  • Cloning and functional expression of a brain G‐protein‐coupled ATP receptor

    Tania E. Webb;Tania E. Webb;Joseph Simon;Joseph Simon;Belinda J. Krishek;Alan N. Bateson

  • Modulation of inhibitory and excitatory amino acid receptor ion channels by zinc.

    Trevor G. Smart;Xinmin Xie;Belinda J. Krishek

  • Constructing inhibitory synapses

    Stephen J. Moss;Trevor G. Smart

  • Nanoscale live-cell imaging using hopping probe ion conductance microscopy.

    Pavel Novak;Chao Li;Andrew I Shevchuk;Ruben Stepanyan

  • A physiological role for endogenous zinc in rat hippocampal synaptic neurotransmission.

    Xinmin Xie;Trevor G. Smart

  • Assembly and cell surface expression of heteromeric and homomeric gamma-aminobutyric acid type A receptors.

    Christopher N. Connolly;Belinda J. Krishek;Bernard J. McDonald;Trevor G. Smart

  • Regulation of GABAA receptor function by protein kinase C phosphorylation

    Belinda J. Krishek;Xinmin Xie;Craig Blackstone;Richard L. Huganir

  • GABA and glycine as neurotransmitters: a brief history

    N G Bowery;T G Smart

  • Constitutive Endocytosis of GABAA Receptors by an Association with the Adaptin AP2 Complex Modulates Inhibitory Synaptic Currents in Hippocampal Neurons

    Josef T. Kittler;Patrick Delmas;Jasmina N. Jovanovic;David A. Brown

  • Functional modulation of GABAA receptors by cAMP-dependent protein phosphorylation

    Stephen J. Moss;Trevor G. Smart;Craig D. Blackstone;Richard L. Huganir

  • Binding, activation and modulation of Cys-loop receptors

    Paul S. Miller;Trevor G. Smart

  • Retrograde activation of presynaptic NMDA receptors enhances GABA release at cerebellar interneuron–Purkinje cell synapses

    Ian C Duguid;Trevor G Smart

  • Adjacent phosphorylation sites on GABAA receptor beta subunits determine regulation by cAMP-dependent protein kinase.

    Bernard J. McDonald;Alessandra Amato;Christopher N. Connolly;Dietmar Benke

  • GABA Potency at GABA(A) Receptors Found in Synaptic and Extrasynaptic Zones.

    Martin Mortensen;Bijal Patel;Trevor G. Smart

  • Brain-derived neurotrophic factor modulates fast synaptic inhibition by regulating GABA(A) receptor phosphorylation, activity, and cell-surface stability.

    Jasmina N. Jovanovic;Philip Thomas;Josef T. Kittler;Trevor G. Smart

  • Zn2+ Ions: Modulators of Excitatory and Inhibitory Synaptic Activity

    Trevor G. Smart;Alastair M. Hosie;Paul S. Miller

  • Zinc-mediated inhibition of GABA(A) receptors: discrete binding sites underlie subtype specificity.

    Alastair M. Hosie;Emma L. Dunne;Robert J. Harvey;Trevor G. Smart

Frequent Co-Authors

Stephen J. Moss
Stephen J. Moss Tufts University
Philip J. Thomas
Philip J. Thomas The University of Texas Southwestern Medical Center
Robert J. Harvey
Robert J. Harvey University of the Sunshine Coast
Josef T. Kittler
Josef T. Kittler University College London
Nicholas J. Brandon
Nicholas J. Brandon Neumora Therapeutics Inc
Andrew Constanti
Andrew Constanti University College London
Ulrike Müller
Ulrike Müller Heidelberg University
Mark I. Rees
Mark I. Rees Swansea University
Diethelm W. Richter
Diethelm W. Richter University of Göttingen
Evgeni Ponimaskin
Evgeni Ponimaskin Hannover Medical School

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