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Biology and Biochemistry

D-Index
93
Citations
30389
World Ranking
2114
National Ranking
13

Overview

Werner Sieghart is affiliated with the Medical University of Vienna in Austria and has contributed extensively to research in neuroscience and related fields. Their work encompasses neuroscience, biochemistry, genetics, and molecular biology, with a particular focus on molecular biology and cellular and molecular neuroscience.

The scientist's publications cover a range of topics primarily centered on neuropharmacology, receptor mechanisms, and ion channel function. Specific main topics of research include:

  • Neuroscience and Neuropharmacology Research
  • Nicotinic Acetylcholine Receptors Study
  • Ion channel regulation and function
  • Pharmacological Receptor Mechanisms and Effects
  • Receptor Mechanisms and Signaling
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Neurological disorders and treatments

They have published in various scientific venues, with frequent publications in:

  • UNC Libraries
  • IUPHAR/BPS Guide to Pharmacology CITE
  • Neurotherapeutics
  • British Journal of Pharmacology
  • Pharmacological Reviews

Notable recent papers by Werner Sieghart include:

  • The Concise Guide to PHARMACOLOGY 2023/24: Ion channels, 2023, British Journal of Pharmacology
  • α6-Containing GABAA Receptors: Functional Roles and Therapeutic Potentials, 2022, Pharmacological Reviews
  • Immunohistochemical distribution of 10 GABA A receptor subunits in the forebrain of the rhesus monkey Macaca mulatta, 2020, The Journal of Comparative Neurology
  • α6GABAA Receptor Positive Modulators Alleviate Migraine-like Grimaces in Mice via Compensating GABAergic Deficits in Trigeminal Ganglia, 2020, Neurotherapeutics
  • Cerebellar α6GABAA Receptors as a Therapeutic Target for Essential Tremor: Proof-of-Concept Study with Ethanol and Pyrazoloquinolinones, 2023, Neurotherapeutics

Collaborations have been an important aspect of their work, with frequent coauthors including:

  • James M. Cook
  • Lih-Chu Chiou
  • John A. Peters
  • Ming Tatt Lee
  • Roman Furtmüller

Best Publications

  • GABAA receptors : Immunocytochemical distribution of 13 subunits in the adult rat brain

    S Pirker;C Schwarzer;A Wieselthaler;W Sieghart

  • International Union of Pharmacology. LXX. Subtypes of γ-Aminobutyric AcidA Receptors: Classification on the Basis of Subunit Composition, Pharmacology, and Function. Update

    Richard W. Olsen;Werner Sieghart

  • Subunit composition, distribution and function of GABA(A) receptor subtypes.

    Sieghart W;Sperk G

  • GABAA receptors: Subtypes provide diversity of function and pharmacology

    Richard W. Olsen;Werner Sieghart

  • Segregation of Different GABAA Receptors to Synaptic and Extrasynaptic Membranes of Cerebellar Granule Cells

    Zoltan Nusser;Werner Sieghart;Peter Somogyi

  • Stoichiometry and Assembly of a Recombinant GABAA Receptor Subtype

    Verena Tretter;Noosha Ehya;Karoline Fuchs;Werner Sieghart

  • Attenuated sensitivity to neuroactive steroids in γ-aminobutyrate type A receptor delta subunit knockout mice

    Robert M. Mihalek;Pradeep K. Banerjee;Esa R. Korpi;Joseph J. Quinlan

  • GABAA receptors: ligand-gated Cl- ion channels modulated by multiple drug-binding sites.

    Werner Sieghart

  • Differential synaptic localization of two major gamma-aminobutyric acid type A receptor alpha subunits on hippocampal pyramidal cells.

    Zoltan Nusser;Werner Sieghart;Dietmar Benke;Jean Marc Fritschy

  • Colocalization of GABA, glycine, and their receptors at synapses in the rat spinal cord

    AJ Todd;C Watt;RC Spike;W Sieghart

  • GABAA receptor subunits in the rat hippocampus I: Immunocytochemical distribution of 13 subunits

    G Sperk;C Schwarzer;K Tsunashima;K Fuchs

  • Structure and subunit composition of GABAA receptors

    W Sieghart;K Fuchs;V Tretter;V Ebert

  • Molecular heterogeneity of benzodiazepine receptors

    Werner Sieghart;Manfred Karobath

  • Structure, Pharmacology, and Function of GABAA Receptor Subtypes

    Werner Sieghart

  • Ligand-Gated Ion Channel Subunit Partnerships: GABAAReceptor α6 Subunit Gene Inactivation Inhibits δ Subunit Expression

    A. Jones;E. R. Korpi;R. M. McKernan;R. Pelz

  • Bidirectional alterations of GABA(A) receptor subunit peptide levels in rat cortex during chronic ethanol consumption and withdrawal.

    Leslie L. Devaud;Jean Marc Fritschy;Werner Sieghart;A. Leslie Morrow

  • Patterns of mRNA and protein expression for 12 GABAA receptor subunits in the mouse brain.

    H. Hörtnagl;R.O. Tasan;A. Wieselthaler;E. Kirchmair

  • Antiallergic drug cromolyn may inhibit histamine secretion by regulating phosphorylation of a mast cell protein

    Theoharis C. Theoharides;Werner Sieghart;Paul Greengard;William W. Douglas

  • GABAA receptor changes in δ subunit‐deficient mice: Altered expression of α4 and γ2 subunits in the forebrain

    Zechun Peng;Birgit Hauer;Robert M. Mihalek;Gregg E. Homanics

  • Photoaffinity labeling of benzodiazepine receptor proteins with the partial inverse agonist [3H]Ro 15-4513: a biochemical and autoradiographic study.

    W. Sieghart;A. Eichinger;J. G. Richards;H. Möhler

Frequent Co-Authors

Siegfried Kasper
Siegfried Kasper Medical University of Vienna
Kurt Hornik
Kurt Hornik Vienna University of Economics and Business
James M. Cook
James M. Cook University of Wisconsin–Milwaukee
Friedrich Leisch
Friedrich Leisch BOKU University
William Wisden
William Wisden Imperial College London
Peter Somogyi
Peter Somogyi University of Oxford
Günther Sperk
Günther Sperk Innsbruck Medical University
Alexander Neumeister
Alexander Neumeister Independent Scientist / Consultant, US
Stephen J. Moss
Stephen J. Moss Tufts University
Gregg E. Homanics
Gregg E. Homanics University of Pittsburgh

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