John R. Atack

Overview

Best Publications

• Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.

  R M McKernan;T W Rosahl;D S Reynolds;C Sur

  1158
  Citations

• Cholinergic correlates of cognitive impairment in Parkinson's disease: comparisons with Alzheimer's disease.

  E K Perry;M Curtis;D J Dick;J M Candy

  799
  Citations

• Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the α5 Subunit of the GABAAReceptor

  Neil Collinson;Frederick M. Kuenzi;Wolfgang Jarolimek;Karen A. Maubach

  772
  Citations

• Aluminosilicates and senile plaque formation in Alzheimer's disease.

  J.M. Candy;J. Klinowski;R.H. Perry;E.K. Perry

  650
  Citations

• Cerebrospinal fluid production is reduced in healthy aging.

  C. May;J. A. Kaye;John R. Atack;M. B. Schapiro

  351
  Citations

• Sedation and Anesthesia Mediated by Distinct GABAA Receptor Isoforms

  David S. Reynolds;Thomas W. Rosahl;Jennifer Cirone;Gillian F. O'Meara

  342
  Citations

• Preferential coassembly of alpha4 and delta subunits of the gamma-aminobutyric acidA receptor in rat thalamus.

  Cyrille Sur;Sophie J. Farrar;Julie Kerby;Paul J. Whiting

  328
  Citations

• Evidence for a Significant Role of α3-Containing GABAA Receptors in Mediating the Anxiolytic Effects of Benzodiazepines

  Rebecca Dias;Wayne F. A. Sheppard;Rosa L. Fradley;Elizabeth M. Garrett

  311
  Citations

• An Inverse Agonist Selective for α5 Subunit-Containing GABAA Receptors Enhances Cognition

  G. R. Dawson;K. A. Maubach;N. Collinson;M. Cobain

  299
  Citations

• Molecular forms of acetylcholinesterase in senile dementia of Alzheimer type: Selective loss of the intermediate (10S) form

  John R. Atack;Elaine K. Perry;James R. Bonham;Robert H. Perry

  293
  Citations

• Loss of the major GABA(A) receptor subtype in the brain is not lethal in mice.

  Cyrille Sur;Keith A. Wafford;David S. Reynolds;Karen L. Hadingham

  270
  Citations

• TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates.

  John R. Atack;Keith A. Wafford;Spencer J. Tye;Susan M. Cook

  266
  Citations

• Different GABAA receptor subtypes mediate the anxiolytic, abuse-related, and motor effects of benzodiazepine-like drugs in primates.

  James K. Rowlett;Donna M. Platt;Snjezana Lelas;John R. Atack

  259
  Citations

• Molecular Forms of Acetylcholinesterase and Butyrylcholinesterase in the Aged Human Central Nervous System

  John R. Atack;Elaine K. Perry;James R. Bonham;John M. Candy

  255
  Citations

• The benzodiazepine binding site of GABA(A) receptors as a target for the development of novel anxiolytics.

  John R Atack

  252
  Citations

• Reductions in [3H]nicotinic acetylcholine binding in Alzheimer's disease and Parkinson's disease: an autoradiographic study.

  Peter J. Whitehouse;A. M. Martino;M. V. Wagster;D. L. Price

  246
  Citations

• The complexity of the GABAA receptor shapes unique pharmacological profiles.

  Charlotte D’Hulst;John R. Atack;R. Frank Kooy

  241
  Citations

• Selective blockade of 5-hydroxytryptamine (5-HT)7 receptors enhances 5-HT transmission, antidepressant-like behavior, and rapid eye movement sleep suppression induced by citalopram in rodents.

  Pascal Bonaventure;Lisa Kelly;Leah Aluisio;Jonathan Shelton

  233
  Citations

• L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for α5-containing GABAA receptors

  John R. Atack;Peter J. Bayley;Guy R. Seabrook;Keith A. Wafford

  223
  Citations

• Effect of alpha subunit on allosteric modulation of ion channel function in stably expressed human recombinant gamma-aminobutyric acid(A) receptors determined using (36)Cl ion flux.

  Alison J. Smith;Luanda Alder;Jonathan Silk;Charles Adkins

  198
  Citations