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Biology and Biochemistry

D-Index
71
Citations
15875
World Ranking
6743
National Ranking
165

Overview

Ross A. D. Bathgate is affiliated with the Florey Institute of Neuroscience and Mental Health in Australia. Their research primarily spans the field of Medicine with a specific focus on Public Health, Environmental and Occupational Health, Molecular Biology, Cellular and Molecular Neuroscience, Occupational Therapy, and Surgery.

Their main topics of work include:

  • Pregnancy-related medical research
  • Receptor Mechanisms and Signaling
  • Neuropeptides and Animal Physiology
  • Occupational Health and Performance
  • Injury Epidemiology and Prevention
  • Neuroendocrine regulation and behavior
  • Pharmacological Receptor Mechanisms and Effects

Bathgate has contributed to various recent publications such as:

  • THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors (2021) in British Journal of Pharmacology
  • The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors (2023) in British Journal of Pharmacology
  • Probing the correlation between ligand efficacy and conformational diversity at the α1A-adrenoreceptor reveals allosteric coupling of its microswitches (2020) in Journal of Biological Chemistry
  • A Novel Antagonist Peptide Reveals a Physiological Role of Insulin-Like Peptide 5 in Control of Colorectal Function (2021) in ACS Pharmacology & Translational Science
  • Ligands selectively tune the local and global motions of neurotensin receptor 1 (NTS1) (2023) in Cell Reports

The frequent co-authors working with Bathgate include:

  • Mohammed Akhter Hossain
  • Daniel J. Scott
  • Paul R. Gooley
  • Praveen Praveen
  • Hongkang Wu

Bathgate's work is often published in notable venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • ACS Pharmacology & Translational Science
  • Nature Communications
  • International Journal of Molecular Sciences
  • Biochemical Pharmacology

The breadth of Bathgate's research includes extensive study within receptor mechanisms and signaling pathways, particularly G protein-coupled receptors. Their contributions also extend into neuropeptides and physiological regulatory processes relevant to animal biology, as well as occupational health and injury prevention. The combination of molecular biology and public health perspectives demonstrates a comprehensive approach to the complex interactions between biomedical sciences and health outcomes.

Best Publications

  • Relaxin Family Peptides and Their Receptors

    R. A. D. Bathgate;M. L. Halls;E. T. van der Westhuizen;G. E. Callander

  • INSL3/Leydig Insulin-like Peptide Activates the LGR8 Receptor Important in Testis Descent

    Jin Kumagai;Sheau Yu Hsu;Hirotaka Matsumi;Jae-Sook Roh

  • Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. Novel members of the relaxin peptide family.

    Ross A.D. Bathgate;Chrishan S. Samuel;Tanya C.D. Burazin;Sharon Layfield

  • THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors

    Stephen P.H. Alexander;Arthur Christopoulos;Anthony P. Davenport;Eamonn Kelly

  • Paracrine regulation of mammalian oocyte maturation and male germ cell survival.

    Kazuhiro Kawamura;Jin Kumagai;Satoko Sudo;Sang-Young Chun

  • International Union of Pharmacology LVII: Recommendations for the Nomenclature of Receptors for Relaxin Family Peptides

    Ross Bathgate;Richard Ivell;Barbara M Sanborn;O David Sherwood

  • Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo

    Chrishan S. Samuel;Elaine N. Unemori;Ishanee Mookerjee;Ross A.D. Bathgate

  • H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2

    Satoko Sudo;Jin Kumagai;Shinya Nishi;Sharon Layfield

  • Relaxin-3 in GABA projection neurons of nucleus incertus suggests widespread influence on forebrain circuits via G-protein-coupled receptor-135 in the rat

    Sherie Ma;Pascal Bonaventure;Tania Ferraro;Pei-Juan Shen

  • Relaxin Reverses Cardiac and Renal Fibrosis in Spontaneously Hypertensive Rats

    Edna D. Lekgabe;Helen Kiriazis;Chongxin Zhao;Qi Xu

  • Evolution of the relaxin-like peptide family

    Tracey N Wilkinson;Terence P Speed;Geoffrey W Tregear;Ross A D Bathgate

  • Restricted, but abundant, expression of the novel rat gene-3 (R3) relaxin in the dorsal tegmental region of brain.

    Tanya C. D. Burazin;Ross A. D. Bathgate;Mary Macris;Sharon Layfield

  • INSL5 is a high affinity specific agonist for GPCR142 (GPR100).

    Changlu Liu;Chester Kuei;Steven Sutton;Jingcai Chen

  • Relaxin deficiency in mice is associated with an age-related progression of pulmonary fibrosis

    Chrishan S Samuel;Chongxin Zhao;Ross A D Bathgate;Courtney Peta Bond

  • Cardiovascular effects of relaxin: from basic science to clinical therapy

    Xiao-Jun Du;Ross A D Bathgate;Chrishan S Samuel;Anthony M Dart

  • The role of insulin 3, testosterone, Müllerian inhibiting substance and relaxin in rat gubernacular growth

    Y. Kubota;C. Temelcos;R.A.D. Bathgate;K.J. Smith

  • Distribution of Relaxin-3 and RXFP3 Within Arousal, Stress, Affective, and Cognitive Circuits of Mouse Brain

    Craig M. Smith;Pei Juan Shen;Avantika Banerjee;Pascal Bonaventure

  • Reproductive Biology of the Relaxin-Like Factor (RLF/INSL3)

    Richard Ivell;Ross A.D. Bathgate

  • Relaxin-3: improved synthesis strategy and demonstration of its high-affinity interaction with the relaxin receptor LGR7 both in vitro and in vivo.

    Ross A. D. Bathgate;Feng Lin;Nicola F. Hanson;Laszlo Otvos

  • Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules.

    Daniel J. Scott;Sharon Layfield;Yan Yan;Yan Yan;Satoko Sudo

Frequent Co-Authors

John D. Wade
John D. Wade Florey Institute of Neuroscience and Mental Health
Geoffrey W. Tregear
Geoffrey W. Tregear University of Melbourne
Daniel Scott
Daniel Scott University of Waterloo
Chrishan S. Samuel
Chrishan S. Samuel Monash University
Roger J. Summers
Roger J. Summers Monash University
Andrew L. Gundlach
Andrew L. Gundlach Florey Institute of Neuroscience and Mental Health
Richard Ivell
Richard Ivell University of Nottingham
Paul R. Gooley
Paul R. Gooley University of Melbourne
K. Johan Rosengren
K. Johan Rosengren University of Queensland
Frances Separovic
Frances Separovic University of Melbourne

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