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Genetics and Molecular Biology
Germany
2024

D-Index & Metrics

Molecular Biology

D-Index
83
Citations
27339
World Ranking
897
National Ranking
72

Research.com Recognitions

  • 2024 - Research.com Genetics and Molecular Biology in Germany Leader Award
  • 2014 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Biochemistry and Biophysics
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Karl-Peter Hopfner is affiliated with Ludwig-Maximilians-Universität München in Germany. Their research spans primarily the fields of Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology, with a particular focus on Molecular Biology and Immunology within these domains.

The scientist's recent publication record includes several papers in notable journals. These are:

  • Molecular mechanisms and cellular functions of cGAS-STING signalling, 2020, Nature Reviews Molecular Cell Biology
  • Structural basis for sequestration and autoinhibition of cGAS by chromatin, 2020, Nature
  • Measuring DNA mechanics on the genome scale, 2020, Nature
  • The cytosolic DNA sensor cGAS recognizes neutrophil extracellular traps, 2021, Science Signaling
  • Ruler elements in chromatin remodelers set nucleosome array spacing and phasing, 2021, Nature Communications

Hopfner's work relates to a variety of topics with a focus on cellular and molecular mechanisms. Main topics include:

  • Genomics and Chromatin Dynamics
  • Interferon and immune responses
  • RNA and protein synthesis mechanisms
  • DNA Repair Mechanisms
  • Immune Response and Inflammation
  • Inflammasome and immune disorders
  • CRISPR and Genetic Engineering

The frequent co-authors indicate ongoing collaborations with several researchers, notably Katja Lammens, Sebastian Eustermann, Gregor Witte, Manuela Moldt, and Felix J. Metzner.

Hopfner's publications appear often in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Molecular Cell
  • The EMBO Journal
  • Nature Reviews Molecular Cell Biology

The scientist has been recognized by election to prestigious organizations, including the German National Academy of Sciences Leopoldina in 2014 for contributions in Biochemistry and Biophysics, as well as membership in the European Molecular Biology Organization (EMBO).

Best Publications

  • Molecular mechanisms and cellular functions of cGAS–STING signalling

    Karl-Peter Hopfner;Veit Hornung

  • cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

    Andrea Ablasser;Marion Goldeck;Taner Cavlar;Tobias Deimling

  • Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily.

    Karl Peter Hopfner;Annette Karcher;David S. Shin;Lisa Craig

  • Structural mechanism of cytosolic DNA sensing by cGAS

    Filiz Civril;Tobias Deimling;Carina C. de Oliveira Mann;Andrea Ablasser

  • The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair

    Karl Peter Hopfner;Lisa Craig;Gabriel Moncalian;Robert A. Zinkel

  • The C-Terminal Regulatory Domain Is the RNA 5'-Triphosphate Sensor of RIG-I.

    Sheng Cui;Katharina Eisenächer;Axel Kirchhofer;Krzysztof Brzózka

  • Structural Biochemistry and Interaction Architecture of the DNA Double-Strand Break Repair Mre11 Nuclease and Rad50-ATPase

    Karl Peter Hopfner;Annette Karcher;Lisa Craig;Tammy T. Woo

  • Modulation of protein properties in living cells using nanobodies

    Axel Kirchhofer;Jonas Helma;Jonas Helma;Katrin Schmidthals;Katrin Schmidthals;Carina Frauer;Carina Frauer

  • 5′-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I

    Andreas Schmidt;Tobias Schwerd;Wolfgang Hamm;Johannes C. Hellmuth

  • Structural Biochemistry of a Bacterial Checkpoint Protein Reveals Diadenylate Cyclase Activity Regulated by DNA Recombination Intermediates

    Gregor Witte;Sophia Hartung;Katharina Büttner;Karl-Peter Hopfner

  • Cytosolic Viral Sensor RIG-I Is a 5′-Triphosphate-Dependent Translocase on Double-Stranded RNA

    Su-A Myong;Sheng Cui;Peter V. Cornish;Peter V. Cornish;Axel Kirchhofer

  • cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein–DNA ladders

    Liudmila Andreeva;Björn Hiller;Dirk Kostrewa;Charlotte Lässig

  • Structural basis for DNA duplex separation by a superfamily-2 helicase.

    Katharina Büttner;Sebastian Nehring;Karl-Peter Hopfner

  • Epitope interactions of monoclonal antibodies targeting CD20 and their relationship to functional properties

    Christian Klein;Alfred Lammens;Wolfgang Schäfer;Guy Georges

  • Crosstalk between the cGAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responses.

    Qiming Liang;Gil Ju Seo;Youn Jung Choi;Mi Jeong Kwak

  • OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids

    Veit Hornung;Rune Hartmann;Andrea Ablasser;Karl Peter Hopfner

  • Establishment of Sister Chromatid Cohesion at the S. cerevisiae Replication Fork

    Armelle Lengronne;Armelle Lengronne;John McIntyre;Yuki Katou;Yutaka Kanoh

  • X-Ray Structures of the Sulfolobus solfataricus SWI2/SNF2 ATPase Core and its Complex with DNA

    Harald Dürr;Christian Körner;Marisa Müller;Volker Hickmann

  • Cytosolic RNA:DNA hybrids activate the cGAS–STING axis

    Arun K Mankan;Tobias Schmidt;Dhruv Chauhan;Marion Goldeck

  • Crystal structure of a thermostable type B DNA polymerase from Thermococcus gorgonarius.

    Karl-Peter Hopfner;Andreas Eichinger;Richard A. Engh;Frank Laue

Frequent Co-Authors

John A. Tainer
John A. Tainer The University of Texas MD Anderson Cancer Center
Veit Hornung
Veit Hornung Ludwig-Maximilians-Universität München
Wolfram Bode
Wolfram Bode Max Planck Society
Taekjip Ha
Taekjip Ha Johns Hopkins University
Heinrich Leonhardt
Heinrich Leonhardt Ludwig-Maximilians-Universität München
Wolfgang Hiddemann
Wolfgang Hiddemann Ludwig-Maximilians-Universität München
Robert Huber
Robert Huber University of Duisburg-Essen
Roland Beckmann
Roland Beckmann Ludwig-Maximilians-Universität München
Georg H. Fey
Georg H. Fey University of Erlangen-Nuremberg
Christian Klein
Christian Klein Roche (Switzerland)

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