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Medicine

D-Index
95
Citations
35607
World Ranking
10007
National Ranking
5151

Overview

Thomas M. Hyde is affiliated with Johns Hopkins University in the United States. Their research primarily focuses on the field of Biochemistry, Genetics and Molecular Biology, with notable contributions to Molecular Biology, Genetics, Neurology, Cellular and Molecular Neuroscience, and Cognitive Neuroscience.

The scientist has published extensively on topics including Single-cell and spatial transcriptomics, Genetic Associations and Epidemiology, Epigenetics and DNA Methylation, Neuroinflammation and Neurodegeneration Mechanisms, Bioinformatics and Genomic Networks, Gene expression and cancer classification, and RNA Research and Splicing.

Some of the recent papers authored or co-authored by Thomas M. Hyde include:

  • Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex, 2021, Nature Neuroscience
  • Molecular landscapes of human hippocampal immature neurons across lifespan, 2022, Nature
  • Single-nucleus transcriptome analysis reveals cell-type-specific molecular signatures across reward circuitry in the human brain, 2021, Neuron
  • Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs, 2020, Nature Communications
  • Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex, 2020, bioRxiv (Cold Spring Harbor Laboratory)

Frequent collaborators include:

  • Joel E. Kleinman
  • Daniel R. Weinberger
  • Leonardo Collado-Torres
  • Andrew E. Jaffe
  • Keri Martinowich

Thomas M. Hyde's work has appeared repeatedly in several key publication venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biological Psychiatry
  • Nature Neuroscience
  • Nature Communications
  • European Neuropsychopharmacology

Best Publications

  • Spatio-temporal transcriptome of the human brain

    Hyo Jung Kang;Yuka Imamura Kawasawa;Feng Cheng;Ying Zhu

  • Functional Analysis of Genetic Variation in Catechol-O-Methyltransferase (COMT): Effects on mRNA, Protein, and Enzyme Activity in Postmortem Human Brain

    Jingshan Chen;Barbara K. Lipska;Nader Halim;Quang D. Ma

  • Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex.

    Kristen R. Maynard;Leonardo Collado-Torres;Lukas M. Weber;Cedric Uytingco

  • Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

    Junghyun Jo;Yixin Xiao;Alfred Xuyang Sun;Engin Cukuroglu

  • Integrative functional genomic analysis of human brain development and neuropsychiatric risks

    Mingfeng Li;Gabriel Santpere;Yuka Imamura Kawasawa;Yuka Imamura Kawasawa;Oleg V Evgrafov

  • Temporal dynamics and genetic control of transcription in the human prefrontal cortex

    Carlo Colantuoni;Barbara K. Lipska;Tianzhang Ye;Thomas M. Hyde;Thomas M. Hyde

  • Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia

    C S Weickert;T M Hyde;B K Lipska;M M Herman

  • Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex

    Kristen Maynard;Leonardo Collado Torres;Lukas M Weber;Cedric Uytingco

  • Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex

    Andrew E Jaffe;Yuan Gao;Amy Deep-Soboslay;Ran Tao

  • Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia.

    Michael F. Egan;Richard E. Straub;Terry E. Goldberg;Imtiaz Yakub

  • Dopaminergic modulation of cortical function in patients with Parkinson's disease.

    Venkata S. Mattay;Alessandro Tessitore;Joseph H. Callicott;Alessandro Bertolino

  • Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5′ SNPs associated with the disease

    Amanda J. Law;Barbara K. Lipska;Cynthia Shannon Weickert;Thomas M. Hyde

  • Large-Scale Cellular-Resolution Gene Profiling in Human Neocortex Reveals Species-Specific Molecular Signatures

    Hongkui Zeng;Elaine H. Shen;John G. Hohmann;Seung Wook Oh

  • Catechol O-methyltransferase mRNA expression in human and rat brain: evidence for a role in cortical neuronal function.

    M. Matsumoto;C.Shannon Weickert;M. Akil;B.K. Lipska

  • DNA Methylation Signatures in Development and Aging of the Human Prefrontal Cortex

    Shusuke Numata;Tianzhang Ye;Tianzhang Ye;Thomas M. Hyde;Thomas M. Hyde;Xavier Guitart-Navarro

  • Relative risk for cognitive impairments in siblings of patients with schizophrenia.

    Michael F Egan;Terry E Goldberg;Tonya Gscheidle;Mary Weirich

  • Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain.

    Cynthia Shannon Weickert;Richard E. Straub;Benjamin W. McClintock;Mitsuyuki Matsumoto

  • Catechol-O-Methyltransferase Genotype and Dopamine Regulation in the Human Brain

    Mayada Akil;Bhaskar S. Kolachana;Debora A. Rothmond;Thomas M. Hyde

  • Psychiatric Disturbances in Metachromatic Leukodystrophy: Insights Into the Neurobiology of Psychosis

    Thomas M. Hyde;James C. Ziegler;Daniel R. Weinberger

  • Dopamine Modulates the Response of the Human Amygdala: A Study in Parkinson's Disease

    Alessandro Tessitore;Ahmad R. Hariri;Francesco Fera;William G. Smith

Frequent Co-Authors

Joel E. Kleinman
Joel E. Kleinman Johns Hopkins University
Daniel R. Weinberger
Daniel R. Weinberger Johns Hopkins University
Andrew E. Jaffe
Andrew E. Jaffe Johns Hopkins University
Mary M. Herman
Mary M. Herman National Institutes of Health
Barbara K. Lipska
Barbara K. Lipska National Institutes of Health
Cynthia Shannon Weickert
Cynthia Shannon Weickert University of New South Wales
Michael F. Egan
Michael F. Egan MSD (United States)
Paul J. Harrison
Paul J. Harrison University of Oxford
Amanda J. Law
Amanda J. Law University of Colorado Denver
Nicholas J. Brandon
Nicholas J. Brandon Neumora Therapeutics Inc

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