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Neuroscience

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111
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Overview

Joel E. Kleinman is affiliated with Johns Hopkins University in the United States. Their research spans multiple aspects of molecular biology, genetics, and neuroscience, with a significant focus on gene expression and brain-related molecular mechanisms.

The scientist's work encompasses key topics including:

  • Genetic Associations and Epidemiology
  • Epigenetics and DNA Methylation
  • Single-cell and spatial transcriptomics
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Bioinformatics and Genomic Networks
  • Gene expression and cancer classification
  • Tryptophan and brain disorders

Kleinman's main fields of study include Biochemistry, Genetics and Molecular Biology with 236 publications, and Neuroscience with 74 publications. Within these, the scientist has contributed to several subfields such as Molecular Biology, Genetics, Neurology, Cellular and Molecular Neuroscience, and Cognitive Neuroscience.

Recent papers authored or co-authored by Kleinman highlight research in spatial gene expression and neuronal molecular signatures. Representative publications include:

  • "Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex," 2021, published in Nature Neuroscience
  • "Molecular landscapes of human hippocampal immature neurons across lifespan," 2022, published in Nature
  • "Single-nucleus transcriptome analysis reveals cell-type-specific molecular signatures across reward circuitry in the human brain," 2021, published in Neuron
  • "Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs," 2020, published in Nature Communications
  • "Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex," 2020, published in bioRxiv (Cold Spring Harbor Laboratory)

Frequent publication venues where Kleinman's research appears include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biological Psychiatry
  • Nature Neuroscience
  • European Neuropsychopharmacology
  • American Journal of Psychiatry

Throughout their career, Kleinman has collaborated extensively with other researchers. Frequent co-authors include Thomas M. Hyde, Daniel R. Weinberger, Leonardo Collado-Torres, Andrew E. Jaffe, and Joo Heon Shin, indicating a collaborative network centered around neuroscience and molecular genetics.

Best Publications

  • Spatio-temporal transcriptome of the human brain

    Hyo Jung Kang;Yuka Imamura Kawasawa;Feng Cheng;Ying Zhu

  • Functional Analysis of Genetic Variation in Catechol-O-Methyltransferase (COMT): Effects on mRNA, Protein, and Enzyme Activity in Postmortem Human Brain

    Jingshan Chen;Barbara K. Lipska;Nader Halim;Quang D. Ma

  • Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex.

    Kristen R. Maynard;Leonardo Collado-Torres;Lukas M. Weber;Cedric Uytingco

  • Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

    Junghyun Jo;Yixin Xiao;Alfred Xuyang Sun;Engin Cukuroglu

  • Integrative functional genomic analysis of human brain development and neuropsychiatric risks

    Mingfeng Li;Gabriel Santpere;Yuka Imamura Kawasawa;Yuka Imamura Kawasawa;Oleg V Evgrafov

  • Temporal dynamics and genetic control of transcription in the human prefrontal cortex

    Carlo Colantuoni;Barbara K. Lipska;Tianzhang Ye;Thomas M. Hyde;Thomas M. Hyde

  • Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia

    C S Weickert;T M Hyde;B K Lipska;M M Herman

  • Abnormal excitatory neurotransmitter metabolism in schizophrenic brains

    Guochuan Tsai;Lucius A. Passani;Barbara S. Slusher;Ruth Carter

  • Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex

    Kristen Maynard;Leonardo Collado Torres;Lukas M Weber;Cedric Uytingco

  • Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex

    Andrew E Jaffe;Yuan Gao;Amy Deep-Soboslay;Ran Tao

  • Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia.

    Michael F. Egan;Richard E. Straub;Terry E. Goldberg;Imtiaz Yakub

  • Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5′ SNPs associated with the disease

    Amanda J. Law;Barbara K. Lipska;Cynthia Shannon Weickert;Thomas M. Hyde

  • Large-Scale Cellular-Resolution Gene Profiling in Human Neocortex Reveals Species-Specific Molecular Signatures

    Hongkui Zeng;Elaine H. Shen;John G. Hohmann;Seung Wook Oh

  • Contrasts between patients with affective disorders and patients with schizophrenia on a neuropsychological test battery

    T E Goldberg;J M Gold;R Greenberg;S Griffin

  • Candidate Endophenotypes for Genetic Studies of Suicidal Behavior

    J. John Mann;Victoria A. Arango;Shelli Avenevoli;David A. Brent

  • Catechol O-methyltransferase mRNA expression in human and rat brain: evidence for a role in cortical neuronal function.

    M. Matsumoto;C.Shannon Weickert;M. Akil;B.K. Lipska

  • The effect of clozapine on cognition and psychiatric symptoms in patients with schizophrenia

    T E Goldberg;R D Greenberg;S J Griffin;J M Gold

  • DNA Methylation Signatures in Development and Aging of the Human Prefrontal Cortex

    Shusuke Numata;Tianzhang Ye;Tianzhang Ye;Thomas M. Hyde;Thomas M. Hyde;Xavier Guitart-Navarro

  • Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain.

    Cynthia Shannon Weickert;Richard E. Straub;Benjamin W. McClintock;Mitsuyuki Matsumoto

  • Disease-associated intronic variants in the ErbB4 gene are related to altered ErbB4 splice-variant expression in the brain in schizophrenia

    Amanda J. Law;Joel E. Kleinman;Daniel R. Weinberger;Cynthia Shannon Weickert

  • Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophrenics

    Jeffrey N. Joyce;Audi Shane;Nedra Lexow;Andrew Winokur

  • Cerebral Ventricular Enlargement in Chronic Schizophrenia: An Association with Poor Response to Treatment

    Daniel R. Weinberger;Llewellyn B. Bigelow;Joel E. Kleinman;Susan T. Klein

Frequent Co-Authors

Thomas M. Hyde
Thomas M. Hyde Johns Hopkins University
Daniel R. Weinberger
Daniel R. Weinberger Johns Hopkins University
Mary M. Herman
Mary M. Herman National Institutes of Health
Cynthia Shannon Weickert
Cynthia Shannon Weickert University of New South Wales
Barbara K. Lipska
Barbara K. Lipska National Institutes of Health
Andrew E. Jaffe
Andrew E. Jaffe Johns Hopkins University
Manuel F. Casanova
Manuel F. Casanova University of South Carolina
Richard Jed Wyatt
Richard Jed Wyatt National Institutes of Health
Amanda J. Law
Amanda J. Law University of Colorado Denver
Paul J. Harrison
Paul J. Harrison University of Oxford

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