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Biology and Biochemistry

D-Index
79
Citations
21245
World Ranking
4340
National Ranking
2114

Overview

Richard Schlegel is affiliated with Georgetown University Medical Center in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a specialized focus on Cancer Research, Oncology, and Molecular Biology. The subfields most represented in their work include Epidemiology and Biotechnology.

The main topics of their research include:

  • Cancer Cells and Metastasis
  • Cancer Genomics and Diagnostics
  • Cervical Cancer and HPV Research
  • Cancer Research and Treatments
  • Cancer, Hypoxia, and Metabolism
  • Epigenetics and DNA Methylation
  • Molecular Biology Techniques and Applications

Richard Schlegel has contributed to multiple recent publications, including:

  • MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer, 2020, British Journal of Cancer
  • Circulating Tumor Cells: Technologies and Their Clinical Potential in Cancer Metastasis, 2021, Biomedicines
  • Efficient Propagation of Circulating Tumor Cells: A First Step for Probing Tumor Metastasis, 2020, Cancers
  • Two conserved amino acids differentiate the biology of high-risk and low-risk HPV E5 proteins, 2022, Journal of Medical Virology
  • Overexpression of the telomerase holoenzyme induces EMT and tumorigenesis of HPV-immortalized keratinocytes, 2023, Journal of Medical Virology

Their work has appeared frequently in several publication venues, including:

  • Journal of Medical Virology
  • UNC Libraries
  • Cancers
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research

Richard Schlegel has collaborated regularly with several coauthors, notably:

  • Jerry Xiao
  • Seema Agarwal
  • Xuefeng Liu
  • Paula R. Pohlmann
  • Hani Goodarzi

Best Publications

  • The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes.

    K Münger;W C Phelps;V Bubb;P M Howley

  • Systemic immunization with papillomavirus L1 protein completely prevents the development of viral mucosal papillomas

    J. A. Suzich;Shin-Je Ghim;F. J. Palmer-Hill;W. I. White

  • ROCK Inhibitor and Feeder Cells Induce the Conditional Reprogramming of Epithelial Cells

    Xuefeng Liu;Virginie Ory;Sandra Chapman;Hang Yuan

  • Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.

    C. Yee;Indira Krishnan-Hewlett;C. C. Baker;R. Schlegel

  • TGF-β1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains

    Jennifer A. Pietenpol;Roland W. Stein;Elizabeth Moran;Peter Yaciuk

  • Transcriptional activation of the telomerase hTERT gene by human papillomavirus type 16 E6 oncoprotein.

    Tim Veldman;Izumi Horikawa;J. Carl Barrett;Richard Schlegel

  • Inhibition of VSV binding and infectivity by phosphatidylserine: Is phosphatidylserine a VSV-binding site?

    Richard Schlegel;Tommie Sue Tralka;Mark C. Willingham;Ira Pastan

  • Immunohistochemical localization of keratin in normal human tissues.

    R Schlegel;S Banks-Schlegel;G S Pinkus

  • The human papillomavirus type 6 and 16 E5 proteins are membrane-associated proteins which associate with the 16-kilodalton pore-forming protein.

    M Conrad;V J Bubb;R Schlegel

  • Human keratinocytes are efficiently immortalized by a Rho kinase inhibitor

    Sandra Chapman;Xuefeng Liu;Craig Meyers;Richard Schlegel

  • Human papillomavirus E6 and Myc proteins associate in vivo and bind to and cooperatively activate the telomerase reverse transcriptase promoter.

    Tim Veldman;Xuefeng Liu;Hang Yuan;Richard Schlegel

  • Immunoperoxidase localization of keratin in human neoplasms: a preliminary survey.

    R. Schlegel;S. Banks-Schlegel;J. A. McLeod;G. S. Pinkus

  • Quantitative keratinocyte assay detects two biological activities of human papillomavirus DNA and identifies viral types associated with cervical carcinoma.

    R. Schlegel;W. C. Phelps;Yu-Lian Zhang;M. Barbosa

  • Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells

    Frank A. Suprynowicz;Geeta Upadhyay;Ewa Krawczyk;Sarah C. Kramer

  • The E6 and E7 genes of HPV-18 are sufficient for inducing two-stage in vitro transformation of human keratinocytes.

    Barbosa Ms;Schlegel R

  • Conditional reprogramming and long-term expansion of normal and tumor cells from human biospecimens

    Xuefeng Liu;Ewa Krawczyk;Frank A Suprynowicz;Nancy Palechor-Ceron

  • The E5 transforming gene of bovine papillomavirus encodes a small, hydrophobic polypeptide

    Richard Schlegel;Marta Wade-Glass;Michael S. Rabson;Yu-Chung Yang

  • Bovine papillomavirus E5 oncoprotein binds to the 16K component of vacuolar H(+)-ATPases.

    David J. Goldstein;Malcolm E. Fmbow;Thorkell Andresson;Pauline McLean

  • Dihydroartemisinin is cytotoxic to papillomavirus-expressing epithelial cells in vitro and in vivo.

    Gary L. Disbrow;Astrid C. Baege;Katie A. Kierpiec;Hang Yuan

  • Amantadine and dansylcadaverine inhibit vesicular stomatitis virus uptake and receptor-mediated endocytosis of alpha 2-macroglobulin

    Richard Schlegel;Robert B. Dickson;Mark C. Willingham;Ira H. Pastan

Frequent Co-Authors

Chris Albanese
Chris Albanese Georgetown University Medical Center
Peter M. Howley
Peter M. Howley Harvard Medical School
Mark C. Willingham
Mark C. Willingham Wake Forest University
Ira Pastan
Ira Pastan Center for Cancer Research
Peter F Moore
Peter F Moore University of California, Davis
Richard C. Boucher
Richard C. Boucher University of North Carolina at Chapel Hill
Scott H. Randell
Scott H. Randell University of North Carolina at Chapel Hill
Jeffrey A. Toretsky
Jeffrey A. Toretsky Georgetown University
John A. Hanover
John A. Hanover National Institutes of Health
Karl Münger
Karl Münger Tufts University

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