D-Index & Metrics Best Publications

Ira Pastan

Center for Cancer Research
United States

Molecular Biology

USA

2023

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name Citations Publications World Ranking National Ranking

Best Scientists D-index 191 Citations 147,621 1,376 World Ranking 282 National Ranking 191

Molecular Biology D-index 181 Citations 138,174 1,229 World Ranking 18 National Ranking 14

Research.com Recognitions

Awards & Achievements

2023 - Research.com Molecular Biology in United States Leader Award

2022 - Research.com Best Scientist Award

2010 - Member of the National Academy of Medicine (NAM)

1998 - Fellow of the American Association for the Advancement of Science (AAAS)

1992 - Fellow of the American Academy of Arts and Sciences

1982 - Member of the National Academy of Sciences

Member of the Association of American Physicians

Overview

What is he best known for?

The fields of study Ira Pastan is best known for:

Gene
Bacteria
Virus

Ira Pastan undertakes multidisciplinary investigations into Molecular biology and Transformation (genetics) in his work. Transformation (genetics) and Genetics are two areas of study in which Ira Pastan engages in interdisciplinary work. He regularly links together related areas like Messenger RNA in his Genetics studies. His multidisciplinary approach integrates Messenger RNA and Translation (biology) in his work. His multidisciplinary approach integrates Translation (biology) and Protein biosynthesis in his work. The study of Protein biosynthesis is intertwined with the study of Molecular biology in a number of ways. Biochemistry and Peptide sequence are commonly linked in his work. His Peptide sequence study frequently draws parallels with other fields, such as Biochemistry. He integrates Gene with Cell culture in his study.

His most cited work include:

Levels of translatable mRNAs for cell surface protein, collagen precursors, and two membrane proteins are altered in Rous sarcoma virus-transformed chick embryo fibroblasts. (284 citations)
Increased cytotoxic activity of Pseudomonas exotoxin and two chimeric toxins ending in KDEL. (194 citations)

What are the main themes of his work throughout his whole career to date

Gene and Homologous recombination are two areas of study in which Ira Pastan engages in interdisciplinary research. Ira Pastan applies his multidisciplinary studies on Homologous recombination and Genetics in his research. His study ties his expertise on Embryo together with the subject of Genetics. He integrates many fields, such as Embryo and Gene, in his works. He combines Molecular biology and Complementary DNA in his studies. Complementary DNA and Molecular biology are two areas of study in which Ira Pastan engages in interdisciplinary work. Cell biology and Function (biology) are commonly linked in his work. His Function (biology) study frequently draws parallels with other fields, such as Cell biology. He performs integrative study on Biochemistry and Cell in his works.

Ira Pastan most often published in these fields:

Gene (70.00%)
Molecular biology (60.00%)
Genetics (60.00%)

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Biochemistry of multidrug resistance mediated by the multidrug transporter.

Michael M. Gottesman;Ira Pastan.
Annual Review of Biochemistry (1993)

5599 Citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

Franz Thiebaut;Takashi Tsuruo;Hirofumi Hamada;Michael M. Gottesman.
Proceedings of the National Academy of Sciences of the United States of America (1987)

4415 Citations

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

Suresh V. Ambudkar;Saibal Dey;Christine A. Hrycyna;Muralidhara Ramachandra.
Annual Review of Pharmacology and Toxicology (1999)

2679 Citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

Chang jie Chen;Janice E. Chin;Kazumitsu Ueda;Douglas P. Clark.
Cell (1986)

2498 Citations

Expression of a multidrug-resistance gene in human tumors and tissues

A T Fojo;K Ueda;D J Slamon;D G Poplack.
Proceedings of the National Academy of Sciences of the United States of America (1987)

2203 Citations

Expression of Multidrug Resistance Gene in Human Cancers

Lori J. Goldstein;Hanan Galski;Antonio Fojo;Mark Willingham.
Journal of the National Cancer Institute (1989)

1725 Citations

The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection

Cornelia M. Gorman;Glenn T. Merlino;Mark C. Willingham;Ira Pastan.
Proceedings of the National Academy of Sciences of the United States of America (1982)

1640 Citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine

Kazumitsu Ueda;Carol Cardarelli;Michael M. Gottesman;Ira Pastan.
Proceedings of the National Academy of Sciences of the United States of America (1987)

1471 Citations

The multidrug transporter, a double-edged sword.

M. M. Gottesman;Ira Pastan.
Journal of Biological Chemistry (1988)

1091 Citations

Modulation of activity of the promoter of the human MDR1 gene by Ras and p53.

Khew-Voon Chin;Kazumitsu Ueda;Ira Pastan;Michael M. Gottesman.
Science (1992)

1055 Citations

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