Michihiko Kuwano

Research.com Recognitions

• 2026 - Research.com Biology and Biochemistry in Japan Leader Award
• 2025 - Research.com Biology and Biochemistry in Japan Leader Award
• 2023 - Research.com Biology and Biochemistry in Japan Leader Award

Overview

Best Publications

• Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis.

  Shigeo Yoshida;Mayumi Ono;Tadahisa Shono;Hiroto Izumi

  839
  Citations

• A Human Canalicular Multispecific Organic Anion Transporter (cMOAT) Gene Is Overexpressed in Cisplatin-resistant Human Cancer Cell Lines with Decreased Drug Accumulation

  Ken Taniguchi;Morimasa Wada;Kimitoshi Kohno;Takanori Nakamura

  695
  Citations

• The pleiotropic functions of the Y-box-binding protein, YB-1.

  Kimitoshi Kohno;Hiroto Izumi;Takeshi Uchiumi;Megumi Ashizuka

  687
  Citations

• Induction of Vascular Endothelial Growth Factor by Tumor Necrosis Factor α in Human Glioma Cells POSSIBLE ROLES OF SP-1

  Masahiro Ryuto;Mayumi Ono;Hiroto Izumi;Shigeo Yoshida

  641
  Citations

• ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase.

  Akira Hirata;Soh-ichiro Ogawa;Takuro Kometani;Takashi Kuwano

  512
  Citations

• Macrophage infiltration correlates with tumor stage and angiogenesis in human malignant melanoma: Possible involvement of TNFα and IL‐1α

  Hitoe Torisu;Mayumi Ono;Hiromaro Kiryu;Masutaka Furue

  503
  Citations

• Molecular mechanisms of epidermal growth factor receptor (EGFR) activation and response to gefitinib and other EGFR-targeting drugs.

  Mayumi Ono;Michihiko Kuwano

  478
  Citations

• Expression profile of class I histone deacetylases in human cancer tissues

  Masamune Nakagawa;Yoshinao Oda;Takashi Eguchi;Shin Ichi Aishima

  457
  Citations

• Expression of vascular endothelial growth factor and its possible relation with neovascularization in human brain tumors.

  Ken Samoto;Kiyonobu Ikezaki;Mayumi Ono;Tadahisa Shono

  450
  Citations

• Sensitivity to gefitinib (Iressa, ZD1839) in non-small cell lung cancer cell lines correlates with dependence on the epidermal growth factor (EGF) receptor/extracellular signal-regulated kinase 1/2 and EGF receptor/Akt pathway for proliferation.

  Mayumi Ono;Akira Hirata;Takuro Kometani;Miho Miyagawa

  435
  Citations

• Macrophage infiltration and heme oxygenase-1 expression correlate with angiogenesis in human gliomas

  Akihiro Nishie;Mayumi Ono;Tadahisa Shono;Junichi Fukushi

  413
  Citations

• Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system.

  Zhe-Sheng Chen;Kun Lee;Susan Walther;Rebecca Blanchard Raftogianis

  411
  Citations

• Involvement of the transcription factor NF-kappaB in tubular morphogenesis of human microvascular endothelial cells by oxidative stress.

  Tadahisa Shono;Mayumi Ono;Hiroto Izumi;Sei Ichiro Jimi

  396
  Citations

• Role of the Human Y Box-binding Protein YB-1 in Cellular Sensitivity to the DNA-damaging Agents Cisplatin, Mitomycin C, and Ultraviolet Light

  Takefumi Ohga;Koji Koike;Mayumi Ono;Yoshinari Makino

  382
  Citations

• A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis

  Hiroyuki Nishimori;Takayuki Shiratsuchi;Takayuki Shiratsuchi;Tsutomu Urano;Yasutoshi Kimura

  374
  Citations

• A Canalicular Multispecific Organic Anion Transporter (cMOAT) Antisense cDNA Enhances Drug Sensitivity in Human Hepatic Cancer Cells

  Koji Koike;Takeshi Kawabe;Toshiya Tanaka;Satoshi Toh

  361
  Citations

• Mutations in the Canalicular Multispecific Organic Anion Transporter (cMOAT) Gene, a Novel ABC Transporter, in Patients with Hyperbilirubinemia II/Dubin-Johnson Syndrome

  Morimasa Wada;Satoshi Toh;Ken Taniguchi;Takanori Nakamura

  358
  Citations

• Cyclooxygenase 2 is a key enzyme for inflammatory cytokine-induced angiogenesis.

  Takashi Kuwano;Shintaro Nakao;Hidetaka Yamamoto;Masazumi Tsuneyoshi

  353
  Citations

• Cellular levels of thioredoxin associated with drug sensitivity to cisplatin, mitomycin C, doxorubicin, and etoposide

  Akira Yokomizo;Mayumi Ono;Hiroki Nanri;Yoshinari Makino

  352
  Citations

• Direct Involvement of the Y-box Binding Protein YB-1 in Genotoxic Stress-induced Activation of the Human Multidrug Resistance 1 Gene

  Takefumi Ohga;Takeshi Uchiumi;Yoshinari Makino;Koji Koike

  342
  Citations