World's Best Scientists 2026 revealed!
Michihiko Kuwano

Michihiko Kuwano

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Biology and Biochemistry
Japan
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
110
Citations
36358
World Ranking
982
National Ranking
48

Medicine

D-Index
111
Citations
36557
World Ranking
5398
National Ranking
117

Michihiko Kuwano publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Michihiko Kuwano sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 491 publications — 95th percentile

95% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Michihiko Kuwano D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Michihiko Kuwano sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 110 D-Index — 95th percentile

95% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2025 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2023 - Research.com Biology and Biochemistry in Japan Leader Award

Overview

Michihiko Kuwano is affiliated with Kyushu University in Japan. Their research focuses on areas within biochemistry, genetics, and molecular biology, with additional involvement in medicine. The scientist has a particular emphasis on molecular biology, pathology and forensic medicine, genetics, cell biology, and oncology.

The main topics covered by their work include the mechanisms of cancer metastasis, cancer mechanisms and therapy, RNA research and splicing, FOXO transcription factor regulation, ubiquitin and proteasome pathways, estrogen and related hormone effects, and Hippo pathway signaling related to YAP/TAZ.

Frequent coauthors include Jun Akiba, Yûichi Murakami, Mayumi Ono, Shin Nishio, and Naotake Tsuda. Alongside collaborative efforts, Michihiko Kuwano has published extensively in notable scientific venues. Key publication outlets comprise The Kurume Medical Journal, Scientific Reports, Research Square, Communications Biology, and Neuropathology.

Representative recent papers include:

  • "NDRG1 activates VEGF-A-induced angiogenesis through PLCγ1/ERK signaling in mouse vascular endothelial cells," 2020, Communications Biology
  • "AXL/CDCP1/SRC axis confers acquired resistance to osimertinib in lung cancer," 2022, Scientific Reports
  • "Elevated expression of N-myc downstream regulated gene 1 protein in glioblastomas reflects tumor angiogenesis and poor patient prognosis," 2024, Neuropathology
  • "Y-box binding protein 1/cyclin A1 axis specifically promotes cell cycle progression at G2/M phase in ovarian cancer," 2024, Scientific Reports
  • "N-Myc Downstream Regulated Gene-1 May Play an Important Role in the Prognosis of Ovarian Cancer, in Its Association with Beta-Catenin," 2022, The Kurume Medical Journal

This body of work illustrates a detailed investigation of cancer biology and molecular processes underlying disease progression and therapy resistance. The scientist's contributions span both experimental and translational research in oncology and molecular medicine.

Best Publications

  • Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis.

    Shigeo Yoshida;Mayumi Ono;Tadahisa Shono;Hiroto Izumi

  • A Human Canalicular Multispecific Organic Anion Transporter (cMOAT) Gene Is Overexpressed in Cisplatin-resistant Human Cancer Cell Lines with Decreased Drug Accumulation

    Ken Taniguchi;Morimasa Wada;Kimitoshi Kohno;Takanori Nakamura

  • The pleiotropic functions of the Y-box-binding protein, YB-1.

    Kimitoshi Kohno;Hiroto Izumi;Takeshi Uchiumi;Megumi Ashizuka

  • Induction of Vascular Endothelial Growth Factor by Tumor Necrosis Factor α in Human Glioma Cells POSSIBLE ROLES OF SP-1

    Masahiro Ryuto;Mayumi Ono;Hiroto Izumi;Shigeo Yoshida

  • ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase.

    Akira Hirata;Soh-ichiro Ogawa;Takuro Kometani;Takashi Kuwano

  • Macrophage infiltration correlates with tumor stage and angiogenesis in human malignant melanoma: Possible involvement of TNFα and IL‐1α

    Hitoe Torisu;Mayumi Ono;Hiromaro Kiryu;Masutaka Furue

  • Molecular mechanisms of epidermal growth factor receptor (EGFR) activation and response to gefitinib and other EGFR-targeting drugs.

    Mayumi Ono;Michihiko Kuwano

  • Expression profile of class I histone deacetylases in human cancer tissues

    Masamune Nakagawa;Yoshinao Oda;Takashi Eguchi;Shin Ichi Aishima

  • Expression of vascular endothelial growth factor and its possible relation with neovascularization in human brain tumors.

    Ken Samoto;Kiyonobu Ikezaki;Mayumi Ono;Tadahisa Shono

  • Sensitivity to gefitinib (Iressa, ZD1839) in non-small cell lung cancer cell lines correlates with dependence on the epidermal growth factor (EGF) receptor/extracellular signal-regulated kinase 1/2 and EGF receptor/Akt pathway for proliferation.

    Mayumi Ono;Akira Hirata;Takuro Kometani;Miho Miyagawa

  • Macrophage infiltration and heme oxygenase-1 expression correlate with angiogenesis in human gliomas

    Akihiro Nishie;Mayumi Ono;Tadahisa Shono;Junichi Fukushi

  • Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system.

    Zhe-Sheng Chen;Kun Lee;Susan Walther;Rebecca Blanchard Raftogianis

  • Involvement of the transcription factor NF-kappaB in tubular morphogenesis of human microvascular endothelial cells by oxidative stress.

    Tadahisa Shono;Mayumi Ono;Hiroto Izumi;Sei Ichiro Jimi

  • Role of the Human Y Box-binding Protein YB-1 in Cellular Sensitivity to the DNA-damaging Agents Cisplatin, Mitomycin C, and Ultraviolet Light

    Takefumi Ohga;Koji Koike;Mayumi Ono;Yoshinari Makino

  • A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis

    Hiroyuki Nishimori;Takayuki Shiratsuchi;Takayuki Shiratsuchi;Tsutomu Urano;Yasutoshi Kimura

  • A Canalicular Multispecific Organic Anion Transporter (cMOAT) Antisense cDNA Enhances Drug Sensitivity in Human Hepatic Cancer Cells

    Koji Koike;Takeshi Kawabe;Toshiya Tanaka;Satoshi Toh

  • Mutations in the Canalicular Multispecific Organic Anion Transporter (cMOAT) Gene, a Novel ABC Transporter, in Patients with Hyperbilirubinemia II/Dubin-Johnson Syndrome

    Morimasa Wada;Satoshi Toh;Ken Taniguchi;Takanori Nakamura

  • Cyclooxygenase 2 is a key enzyme for inflammatory cytokine-induced angiogenesis.

    Takashi Kuwano;Shintaro Nakao;Hidetaka Yamamoto;Masazumi Tsuneyoshi

  • Cellular levels of thioredoxin associated with drug sensitivity to cisplatin, mitomycin C, doxorubicin, and etoposide

    Akira Yokomizo;Mayumi Ono;Hiroki Nanri;Yoshinari Makino

  • Direct Involvement of the Y-box Binding Protein YB-1 in Genotoxic Stress-induced Activation of the Human Multidrug Resistance 1 Gene

    Takefumi Ohga;Takeshi Uchiumi;Yoshinari Makino;Koji Koike

Frequent Co-Authors

Mayumi Ono
Mayumi Ono Kyushu University
Kimitoshi Kohno
Kimitoshi Kohno University of Occupational and Environmental Health Japan
Takeshi Uchiumi
Takeshi Uchiumi Kyushu University
Shin-ichi Akiyama
Shin-ichi Akiyama Kagoshima University
Hiroto Izumi
Hiroto Izumi University of Occupational and Environmental Health Japan
Masazumi Tsuneyoshi
Masazumi Tsuneyoshi Kyushu University
Seiji Naito
Seiji Naito Kyushu University
Yoshinao Oda
Yoshinao Oda Kyushu University
Yasufumi Sato
Yasufumi Sato Tohoku University
Yoshihiko Maehara
Yoshihiko Maehara Kyushu University

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