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Biology and Biochemistry
Germany
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
100
Citations
37663
World Ranking
1515
National Ranking
99

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2025 - Research.com Biology and Biochemistry in Germany Leader Award
  • 2023 - Research.com Biology and Biochemistry in Germany Leader Award

Overview

Dietrich Keppler is affiliated with the German Cancer Research Center in Germany. Their research activity is focused primarily within the fields of Medicine and its related subfields, including Oncology, Hepatology, and Surgery.

The main research topics addressed in Keppler's work encompass:

  • Drug Transport and Resistance Mechanisms
  • Liver Diseases and Immunity
  • Pediatric Hepatobiliary Diseases and Treatments

Their publication record includes a paper titled "A life with bile acids: Alan F. Hofmann (1931-2021)" published in 2021 in the Journal of Hepatology. This is the recorded venue for their work, which aligns closely with their medical focus, particularly in hepatology.

Frequent coauthors in their research include Ulrich Beuers and Michael Trauner, both of whom have contributed to collaborative publications with Keppler.

Best Publications

  • Membrane transporters in drug development.

    Kathleen M. Giacomini;Shiew Mei Huang;Donald J. Tweedie;Leslie Z. Benet

  • The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.

    I. Leier;G. Jedlitschky;U. Buchholz;S. P. C. Cole

  • Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance.

    Jörg König;Anne T. Nies;Yunhai Cui;Inka Leier

  • Drug Resistance and ATP-Dependent Conjugate Transport Mediated by the Apical Multidrug Resistance Protein, MRP2, Permanently Expressed in Human and Canine Cells

    Y Cui;J König;J K Buchholz;H Spring

  • cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats.

    Markus Büchler;Jörg König;Manuela Brom;Jürgen Kartenbeck

  • A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane

    Jörg König;Yunhai Cui;Anne T. Nies;Dietrich Keppler

  • Experimental hepatitis induced by d-galactosamine

    D. Keppler;R. Lesch;W. Reutter;K. Decker

  • Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump.

    Gabriele Jedlitschky;Inka Leier;Ulrike Buchholz;Karin Barnouin

  • Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide.

    Jörg König;Yunhai Cui;Anne T. Nies;Dietrich Keppler

  • Hepatic Uptake of Bilirubin and Its Conjugates by the Human Organic Anion Transporter SLC21A6

    Yunhai Cui;Jörg König;Inka Leier;Ulrike Buchholz

  • Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane

    Jörg König;Daniel Rost;Yunhai Cui;Dietrich Keppler

  • The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis

    Michael Trauner;Marco Arrese;Carol J. Soroka;Meenakshisundaram Ananthanarayanan

  • Galactosamine hepatitis: Key role of the nucleotide deficiency period in the pathogenesis of cell injury and cell death

    K Decker;D Keppler

  • The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides.

    Gabriele Jedlitschky;Brian Burchell;Dietrich Keppler

  • ATP-dependent Transport of Glutathione S-Conjugates by the Multidrug Resistance-associated Protein

    Gabriele Jedlitschky;Inka Leier;Ulrike Buchholz

  • Absence of the canalicular isoform of the MRP gene–encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome

    J Kartenbeck;U Leuschner;R Mayer;D Keppler

  • Expression and immunolocalization of the multidrug resistance proteins, MRP1-MRP6 (ABCC1-ABCC6), in human brain

    A.T. Nies;G. Jedlitschky;J. König;C. Herold-Mende

  • The apical conjugate efflux pump ABCC2 (MRP2)

    Anne T. Nies;Dietrich Keppler

  • Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane

    Maria Rius;Anne T. Nies;Johanna Hummel‐Eisenbeiss;Gabriele Jedlitschky

  • Characterization of the Human Multidrug Resistance Protein Isoform MRP3 Localized to the Basolateral Hepatocyte Membrane. Hepatology, 29, 1156-1163

    Jörg König;Cui Yh;Daniel Rost;Yunhai Cui

Frequent Co-Authors

Karl Decker
Karl Decker University of Freiburg
Michael Müller
Michael Müller University of East Anglia
Michael Huber
Michael Huber University of Zurich
Wolfgang Gerok
Wolfgang Gerok University of Freiburg
Markus W. Büchler
Markus W. Büchler Champalimaud Foundation
Jürgen Kartenbeck
Jürgen Kartenbeck German Cancer Research Center
Toshihisa Ishikawa
Toshihisa Ishikawa NGO Personalized Medicine & Healthcare
Werner Reutter
Werner Reutter Freie Universität Berlin
Ertan Mayatepek
Ertan Mayatepek Heinrich Heine University Düsseldorf
Christel Herold-Mende
Christel Herold-Mende Heidelberg University

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