2023 - Research.com Biology and Biochemistry in Germany Leader Award
The scientist’s investigation covers issues in Biochemistry, Multidrug resistance-associated protein 2, Glutathione, Glucuronate and Molecular biology. Efflux, Transport protein, Hepatocyte, ABCC1 and Adenosine triphosphate are among the areas of Biochemistry where the researcher is concentrating his efforts. Dietrich Keppler combines subjects such as Apical membrane, Membrane glycoproteins, Membrane transport protein and Gene isoform with his study of Multidrug resistance-associated protein 2.
Dietrich Keppler interconnects Leukotriene C4, Vesicle and Membrane transport in the investigation of issues within Glutathione. The Glucuronate study combines topics in areas such as Dubin–Johnson syndrome and Membrane protein. His biological study spans a wide range of topics, including Lipopolysaccharide, Galactosamine, Pyrimidine, Ratón and Precursor cell.
Dietrich Keppler mainly investigates Biochemistry, Multidrug resistance-associated protein 2, Molecular biology, Hepatocyte and Internal medicine. His work deals with themes such as Leukotriene C4 and In vivo, which intersect with Biochemistry. His Multidrug resistance-associated protein 2 research is multidisciplinary, incorporating perspectives in Transport protein, Epithelial polarity, Membrane transport protein, Apical membrane and Membrane glycoproteins.
The study incorporates disciplines such as Cholestasis, Secretion, Vesicle, Adenosine triphosphate and Cyclosporin a in addition to Hepatocyte. His Internal medicine research incorporates elements of Endocrinology and Leukotriene E4. His studies in Glutathione integrate themes in fields like Membrane, Membrane transport and Glycoprotein.
Dietrich Keppler focuses on Biochemistry, Efflux, Multidrug resistance-associated protein 2, Transporter and Apical membrane. His Biochemistry study often links to related topics such as Bilirubin. His studies examine the connections between Efflux and genetics, as well as such issues in Epithelial polarity, with regards to Transfection, Berberine and Organic cation transport.
His Multidrug resistance-associated protein 2 research is multidisciplinary, relying on both Organic anion transporter 1, Organic anion-transporting polypeptide, Cholestasis and Dubin–Johnson syndrome. His research investigates the connection with Transporter and areas like Pharmacology which intersect with concerns in Drug discovery. His research integrates issues of Concentrative nucleoside transporter, Cell biology, Equilibrative nucleoside transporter and Nucleoside in his study of Apical membrane.
Biochemistry, Multidrug resistance-associated protein 2, Efflux, Cholestasis and Pharmacology are his primary areas of study. In his study, which falls under the umbrella issue of Biochemistry, ABCC4 is strongly linked to Blood–brain barrier. His Multidrug resistance-associated protein 2 study combines topics in areas such as Glutathione and Glucuronate.
His study focuses on the intersection of Efflux and fields such as Apical membrane with connections in the field of Secretion, Epithelial polarity, Cell culture, Cell membrane and Dubin–Johnson syndrome. In his study, Organic anion transporter 1, P-glycoprotein, Transport protein and Organic anion-transporting polypeptide is strongly linked to Bile Salt Export Pump, which falls under the umbrella field of Cholestasis. His Pharmacology research includes elements of Transporter, SLC47A1 and Drug discovery.
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Membrane transporters in drug development.
Kathleen M. Giacomini;Shiew Mei Huang;Donald J. Tweedie;Leslie Z. Benet.
Nature Reviews Drug Discovery (2010)
The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.
I. Leier;G. Jedlitschky;U. Buchholz;S. P. C. Cole.
Journal of Biological Chemistry (1994)
Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance.
Jörg König;Anne T. Nies;Yunhai Cui;Inka Leier.
Biochimica et Biophysica Acta (1999)
Drug Resistance and ATP-Dependent Conjugate Transport Mediated by the Apical Multidrug Resistance Protein, MRP2, Permanently Expressed in Human and Canine Cells
Yunhai Cui;Jörg König;Ulrike Buchholz;Herbert Spring.
Molecular Pharmacology (1999)
cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats.
Markus Büchler;Jörg König;Manuela Brom;Jürgen Kartenbeck.
Journal of Biological Chemistry (1996)
Experimental hepatitis induced by d-galactosamine
D. Keppler;R. Lesch;W. Reutter;K. Decker.
Experimental and Molecular Pathology (1968)
Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump.
Gabriele Jedlitschky;Inka Leier;Ulrike Buchholz;Karin Barnouin.
Cancer Research (1996)
A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane
Jörg König;Yunhai Cui;Anne T. Nies;Dietrich Keppler.
American Journal of Physiology-gastrointestinal and Liver Physiology (2000)
Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide.
Jörg König;Yunhai Cui;Anne T. Nies;Dietrich Keppler.
Journal of Biological Chemistry (2000)
The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis
Michael Trauner;Marco Arrese;Carol J. Soroka;Meenakshisundaram Ananthanarayanan.
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