Toshihisa Ishikawa

Overview

Best Publications

• Membrane transporters in drug development.

  Kathleen M. Giacomini;Shiew Mei Huang;Donald J. Tweedie;Leslie Z. Benet

  3316
  Citations

• Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells : molecular characterization of glutathione-platinum complex and its biological significance

  T Ishikawa;F Ali-Osman

  734
  Citations

• ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione S-conjugates.

  T Ishikawa;M Müller;C Klünemann;T Schaub

  383
  Citations

• The roles of copper transporters in cisplatin resistance.

  Macus Tien Kuo;Helen Hai-Wen Chen;Helen Hai-Wen Chen;Irn-Sook Song;Niramol Savaraj

  359
  Citations

• A SNP in the ABCC11 gene is the determinant of human earwax type

  Koh Ichiro Yoshiura;Akira Kinoshita;Takafumi Ishida;Aya Ninokata

  349
  Citations

• Transport of 7-Ethyl-10-hydroxycamptothecin (SN-38) by Breast Cancer Resistance Protein ABCG2 in Human Lung Cancer Cells

  Katsumi Nakatomi;Megumi Yoshikawa;Mikio Oka;Yoji Ikegami

  261
  Citations

• Nuclear Receptor-Mediated Transcriptional Regulation in Phase I, II, and III Xenobiotic Metabolizing Systems

  Kotoko Nakata;Yoshitomo Tanaka;Tatsuya Nakano;Tatsuhiko Adachi

  250
  Citations

• ATP-dependent transport of taurocholate across the hepatocyte canalicular membrane mediated by a 110-kDa glycoprotein binding ATP and bile salt.

  M Müller;T Ishikawa;U Berger;C Klünemann

  232
  Citations

• The GS-X Pump in Plant, Yeast, and Animal Cells: Structure, Function, and Gene Expression

  Toshihisa Ishikawa;Ze-Sheng Li;Yu-Ping Lu;Philip A. Rea

  211
  Citations

• Major SNP (Q141K) variant of human ABC transporter ABCG2 undergoes lysosomal and proteasomal degradations.

  Tomoka Furukawa;Kanako Wakabayashi;Ai Tamura;Hiroshi Nakagawa

  197
  Citations

• Functional validation of the genetic polymorphisms of human ATP-binding cassette (ABC) transporter ABCG2: identification of alleles that are defective in porphyrin transport

  Ai Tamura;Masato Watanabe;Hikaru Saito;Hiroshi Nakagawa

  190
  Citations

• Re-evaluation and functional classification of non- synonymous single nucleotide polymorphisms of the human ATP-binding cassette transporter ABCG2

  Ai Tamura;Kanako Wakabayashi;Yuko Onishi;Misako Takeda

  175
  Citations

• A functional study on polymorphism of the ATP-binding cassette transporter ABCG2: critical role of arginine-482 in methotrexate transport.

  Hideyuki Mitomo;Ryo Kato;Akiko Ito;Shiho Kasamatsu

  168
  Citations

• MRP class of human ATP binding cassette (ABC) transporters: historical background and new research directions

  Y. Toyoda;Y. Hagiya;T. Adachi;K. Hoshijima

  167
  Citations

• Multiple Splicing Variants of Two New Human ATP-Binding Cassette Transporters, ABCC11 and ABCC12

  Hikaru Yabuuchi;Hidetada Shimizu;Shin-ichiro Takayanagi;Toshihisa Ishikawa

  148
  Citations

• Inhibition by Cyclosporin A of Adenosine Triphosphate- Dependent Transport From the Hepatocyte Into Bile

  Martina Kadmon;Cornelia Klünemann;Matthias Böhme;Toshihisa Ishikawa

  136
  Citations

• Nrf2-dependent and -independent induction of ABC transporters ABCC1, ABCC2, and ABCG2 in HepG2 cells under oxidative stress.

  Tatsuhiko Adachi;Hiroshi Nakagawa;Ivy Chung;Ivy Chung;Yuichiro Hagiya

  128
  Citations

• A New Strategy of High-Speed Screening and Quantitative Structure-Activity Relationship Analysis to Evaluate Human ATP-Binding Cassette Transporter ABCG2-Drug Interactions

  Hikaru Saito;Hiroyuki Hirano;Hiroshi Nakagawa;Takeaki Fukami

  126
  Citations

• Earwax, osmidrosis, and breast cancer: why does one SNP (538G>A) in the human ABC transporter ABCC11 gene determine earwax type?

  Yu Toyoda;Aki Sakurai;Yasumasa Mitani;Masahiro Nakashima

  116
  Citations

• Disruption of N-linked glycosylation enhances ubiquitin-mediated proteasomal degradation of the human ATP-binding cassette transporter ABCG2.

  Hiroshi Nakagawa;Kanako Wakabayashi-Nakao;Ai Tamura;Yu Toyoda

  115
  Citations