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Biology and Biochemistry
Switzerland
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
100
Citations
36040
World Ranking
1520
National Ranking
34

Medicine

D-Index
101
Citations
36598
World Ranking
8000
National Ranking
111

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Switzerland Leader Award

Overview

Bruno Stieger is affiliated with the University of Zurich in Switzerland and conducts research primarily in the field of Medicine, with a focus on Pathology and Forensic Medicine, Oncology, Molecular Biology, Materials Chemistry, and Hepatology. Their work covers a range of topics including parasitic infections in humans and animals, drug transport and resistance mechanisms, liver disease diagnosis and treatment, pediatric hepatobiliary diseases and treatments, pharmacological effects and toxicity studies, crystallization and solubility studies, and X-ray diffraction in crystallography.

Stieger's recent publications reflect this diverse focus. Key papers include:

  • Membrane lipids and transporter function, 2021, published in Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  • Structure of human drug transporters OATP1B1 and OATP1B3, 2023, published in Nature Communications
  • Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver, 2022, published in Cell Research
  • Structures of ABCB4 provide insight into phosphatidylcholine translocation, 2021, published in Proceedings of the National Academy of Sciences
  • Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP, 2023, published in Nature Communications

Frequent coauthors collaborating with Stieger include Cristina Gómez, Fadi Jebbawi, Michael Weingärtner, Junhua Wang, and Simon Stücheli, indicating a consistent professional network.

The scientist regularly publishes in venues such as Zenodo (CERN European Organization for Nuclear Research), Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature, The Cambridge Structural Database, Nature Communications, and the Journal of Pharmacology and Experimental Therapeutics.

Best Publications

  • The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver.

    Thomas Gerloff;Bruno Stieger;Bruno Hagenbuch;Jerzy Madon

  • Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

    Patricio Godoy;Nicola J. Hewitt;Ute Albrecht;Melvin E. Andersen

  • Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver

    Gerd A. Kullak-Ublick;Manfred G. Ismair;Bruno Stieger;Lukas Landmann

  • Enterohepatic Bile Salt Transporters in Normal Physiology and Liver Disease

    Gerd A. Kullak-ublick;Bruno Stieger;Peter J. Meier

  • St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4

    Donat Dürr;Bruno Stieger;Gerd A. Kullak‐Ublick;Katharina M. Rentsch

  • Bile Salt Transporters

    Peter J Meier;B Stieger

  • Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver.

    Bruno Stieger;Karin Fattinger;Jerzy Madon;Gerd A. Kullak-Ublick

  • Expression cloning of a rat liver Na(+)-independent organic anion transporter.

    Emmanuel Jacquemin;Bruno Hagenbuch;Bruno Stieger;Allan W. Wolkoff

  • A high yield preparation for rat kidney brush border membranes Different behaviour of lysosomal markers

    Juerg Biber;Bruno Stieger;Winfried Haase;Heini Murer

  • Functional expression cloning and characterization of the hepatocyte Na+/bile acid cotransport system.

    Bruno Hagenbuch;Bruno Stieger;Montserrat Foguet;Hermann Lubbert

  • Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver.

    Gerd A. Kullak-Ublick;Bruno Hagenbuch;Bruno Stieger;Claudio D. Schteingart

  • Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain.

    Birgitta Noé;Bruno Hagenbuch;Bruno Stieger;Peter J. Meier

  • Sphingomyelin synthesis in rat liver occurs predominantly at the cis and medial cisternae of the Golgi apparatus.

    A H Futerman;B Stieger;A L Hubbard;R E Pagano

  • Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver

    P J Meier;U Eckhardt;A Schroeder;B Hagenbuch

  • Localization of the organic anion transporting polypeptide 2 (Oatp2) in capillary endothelium and choroid plexus epithelium of rat brain

    Bo Gao;Bruno Stieger;Birgitta Noé;Jean-Marc Fritschy

  • Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter.

    F. Pizzagalli;B. Hagenbuch;B. Stieger;U. Klenk

  • Hepatocellular carcinoma in ten children under five years of age with bile salt export pump deficiency.

    A. S. Knisely;Sandra S. Strautnieks;Yvonne Meier;Bruno Stieger

  • Severe bile salt export pump deficiency: 82 different ABCB11 mutations in 109 families.

    Sandra S. Strautnieks;Jane A. Byrne;Ludmila Pawlikowska;Dita Cebecauerova

  • The SLCO (former SLC21) superfamily of transporters

    Bruno Hagenbuch;Bruno Stieger

  • Bosentan Is a Substrate of Human OATP1B1 and OATP1B3: Inhibition of Hepatic Uptake as the Common Mechanism of Its Interactions with Cyclosporin A, Rifampicin, and Sildenafil

    Alexander Treiber;Ralph Schneiter;Stephanie Häusler;Bruno Stieger

Frequent Co-Authors

Bruno Hagenbuch
Bruno Hagenbuch University of Kansas
Heini Murer
Heini Murer University of Zurich
Olivier Fardel
Olivier Fardel University of Rennes
Stephan Krähenbühl
Stephan Krähenbühl University of Basel
Ronald P.J. Oude Elferink
Ronald P.J. Oude Elferink University of Amsterdam
Yuichi Sugiyama
Yuichi Sugiyama University of Tokyo
Robert J. Porte
Robert J. Porte University Medical Center Groningen
Ulrich Beuers
Ulrich Beuers University of Amsterdam
Achim Weber
Achim Weber University of Zurich

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