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Ronald P.J. Oude Elferink

Ronald P.J. Oude Elferink

D-Index & Metrics

Medicine

D-Index
88
Citations
28809
World Ranking
13148
National Ranking
504

Overview

Ronald P.J. Oude Elferink is affiliated with the University of Amsterdam in the Netherlands. Their research primarily focuses on medicine, with significant contributions in biochemistry, genetics, and molecular biology. Within these broader fields, they have a notable presence in molecular biology, oncology, surgery, epidemiology, and hepatology.

Their work covers several main topics related to liver function and disease, including:

  • Drug transport and resistance mechanisms
  • Pediatric hepatobiliary diseases and treatments
  • Liver disease diagnosis and treatment
  • Liver diseases and immunity
  • Mitochondrial function and pathology
  • Ion transport and channel regulation
  • Dermatology and skin diseases

They have published extensively in journals such as:

  • Hepatology
  • Journal of Hepatology
  • JHEP Reports
  • APOPTOSIS
  • Liver International

Notable recent papers by Ronald P.J. Oude Elferink include:

  • Mechanisms of pruritus in cholestasis: understanding and treating the itch, 2022, Nature Reviews Gastroenterology & Hepatology
  • Targeting the Four Pillars of Enterohepatic Bile Salt Cycling; Lessons From Genetics and Pharmacology, 2020, Hepatology
  • The extracellular lactate-to-pyruvate ratio modulates the sensitivity to oxidative stress-induced apoptosis via the cytosolic NADH/NAD+ redox state, 2020, APOPTOSIS
  • Molecular regulation of the hepatic bile acid uptake transporter and HBV entry receptor NTCP, 2021, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  • Cholestasis-Associated Pruritus and Its Pruritogens, 2021, Frontiers in Medicine

The scientist has collaborated frequently with a number of co-authors, including:

  • Stan F.J. van de Graaf
  • Arthur J. Verhoeven
  • Ulrich Beuers
  • Jung-Chin Chang
  • Simei Go

Best Publications

  • Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene.

    Coen C. Paulusma;Piter J. Bosma;Guido J. R. Zaman;Conny T. M. Bakker

  • The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria

    Johan W. Jonker;Marije Buitelaar;Els Wagenaar;Martin A. van der Valk

  • Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis

    J. M. L. De Vree;E. Jacquemin;E. Sturm;D. Cresteil

  • MRP3, an organic anion transporter able to transport anti-cancer drugs

    M. Kool;M. van der Linden;M. de Haas;G. L. Scheffer

  • Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein

    G J Zaman;J Lankelma;O van Tellingen;J Beijnen

  • Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA.

    R. Evers;M. Kool;L. Van Deemter;H. Janssen

  • The wide spectrum of multidrug resistance 3 deficiency: From neonatal cholestasis to cirrhosis of adulthood☆☆☆

    Emmanuel Jacquemin;Olivier Bernard;Michelle Hadchouel;Danièle Cresteil

  • Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man.

    P. J. Bosma;J. Seppen;B. Goldhoorn;C. Bakker

  • Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport.

    Ronald P.J. Oude Elferink;Dirk K.F. Meijer;Folkert Kuipers;Peter L.M. Jansen

  • Lysophosphatidic Acid Is a Potential Mediator of Cholestatic Pruritus

    Andreas E. Kremer;Job J.W.W. Martens;Wim Kulik;Franziska Ruëff

  • Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver

    Evita van de Steeg;Viktor Stránecký;Hana Hartmannová;Lenka Nosková

  • The biliary HCO3− umbrella: A unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies

    Ulrich Beuers;Simon Hohenester;Lucas J. Maillette de Buy Wenniger;Andreas E. Kremer

  • Tissue Distribution and Induction of Human Multidrug Resistant Protein 3

    George L Scheffer;Marcel Kool;Marcel de Haas;J Marleen L de Vree

  • Function and pathophysiological importance of ABCB4 (MDR3 P-glycoprotein)

    Ronald P. J. Oude Elferink;Coen C. Paulusma

  • A biliary HCO3- umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes.

    Simon Hohenester;Simon Hohenester;Lucas Maillette de Buy Wenniger;Coen C. Paulusma;Sandra J. van Vliet

  • Atp8b1 deficiency in mice reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport.

    Coen C. Paulusma;Annemiek Groen;Cindy Kunne;Kam S. Ho-Mok

  • Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions

    Andreas E. Kremer;Remco van Dijk;Pamela Leckie;Frank G. Schaap

  • Specific Detection of Multidrug Resistance Proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-Glycoprotein with a Panel of Monoclonal Antibodies

    George L. Scheffer;Marcel Kool;Marc Heijn;Marcel de Haas

  • Sequence of exons and the flanking regions of human bilirubin-UDP-glucuronosyltransferase gene complex and identification of a genetic mutation in a patient with Crigler-Najjar syndrome, type I

    Piter J. Bosma;Namita Roy Chowdhury;Bart G. Goldhoorn;Martin H. Hofker

  • Direct intestinal cholesterol secretion contributes significantly to total fecal neutral sterol excretion in mice.

    Astrid E. van der Velde;Carlos L.J. Vrins;Karin van den Oever;Cindy Kunne

Frequent Co-Authors

Ulrich Beuers
Ulrich Beuers University of Amsterdam
Albert K. Groen
Albert K. Groen University of Amsterdam
Folkert Kuipers
Folkert Kuipers University Medical Center Groningen
Peter L.M. Jansen
Peter L.M. Jansen Maastricht University
James L. Boyer
James L. Boyer Yale University
Jesús Prieto
Jesús Prieto University of Navarra
Jorge Rakela
Jorge Rakela Mayo Clinic
Hartmut Jaeschke
Hartmut Jaeschke University of Kansas
Tania Roskams
Tania Roskams KU Leuven
J. M. Tager
J. M. Tager University of Amsterdam

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