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Medicine
Netherlands
2023

D-Index & Metrics

Medicine

D-Index
151
Citations
96630
World Ranking
1106
National Ranking
40

Research.com Recognitions

  • 2023 - Research.com Medicine in Netherlands Leader Award
  • 2010 - Royal Netherlands Academy of Arts and Sciences

Overview

Jos H. Beijnen is affiliated with Utrecht University in the Netherlands and has a significant body of research primarily in the field of Medicine, with a focus on Oncology, Molecular Biology, Pharmacology, Pulmonary and Respiratory Medicine, and Epidemiology.

Their work encompasses various topics, including:

  • Drug Transport and Resistance Mechanisms
  • Pharmacogenetics and Drug Metabolism
  • Colorectal Cancer Treatments and Studies
  • Cancer Treatment and Pharmacology
  • Lung Cancer Treatments and Mutations
  • Cancer therapeutics and mechanisms
  • Pharmacological Effects and Toxicity Studies

Frequent publication venues for Jos H. Beijnen include:

  • Journal of Chromatography B
  • Journal of Pharmaceutical and Biomedical Analysis
  • Clinical Pharmacokinetics
  • Cancer Chemotherapy and Pharmacology
  • Clinical Pharmacology & Therapeutics

Their recent published papers illustrate a strong focus on cancer-related pharmacology and immunotherapy:

  • "Tumor-Infiltrating Lymphocyte Therapy or Ipilimumab in Advanced Melanoma," 2022, New England Journal of Medicine
  • "Tumor infiltrating lymphocytes (TIL) therapy in metastatic melanoma: boosting of neoantigen-specific T cell reactivity and long-term follow-up," 2020, Journal for ImmunoTherapy of Cancer
  • "The Mechanism-Based Inactivation of CYP3A4 by Ritonavir: What Mechanism?", 2022, International Journal of Molecular Sciences
  • "Pharmacokinetics and Pharmacodynamics of PARP Inhibitors in Oncology," 2022, Clinical Pharmacokinetics
  • "Clinical Pharmacokinetics and Pharmacodynamics of the Cyclin-Dependent Kinase 4 and 6 Inhibitors Palbociclib, Ribociclib, and Abemaciclib," 2020, Clinical Pharmacokinetics

Jos H. Beijnen has worked alongside frequent co-authors such as:

  • Alwin D. R. Huitema
  • Hilde Rosing
  • Alfred H. Schinkel
  • Thomas P. C. Dorlo
  • Neeltje Steeghs

In recognition of scientific contributions, Jos H. Beijnen was awarded membership in the Royal Netherlands Academy of Arts and Sciences in 2010.

Best Publications

  • Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

    A.H. Schinkel;J.J.M. Smit;O. van Tellingen;J.H. Beijnen

  • A Phase I and Pharmacological Study with Imidazolium-trans-DMSO-imidazole-tetrachlororuthenate, a Novel Ruthenium Anticancer Agent

    Jeany M. Rademaker-Lakhai;Desiree van den Bongard;Dick Pluim;Jos H. Beijnen

  • Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

    A. Sparreboom;J. van Asperen;U. Mayer;A.H. Schinkel

  • The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria

    Johan W. Jonker;Marije Buitelaar;Els Wagenaar;Martin A. van der Valk

  • Role of Breast Cancer Resistance Protein in the Bioavailability and Fetal Penetration of Topotecan

    Johan W. Jonker;Johan W. Smit;Remco F. Brinkhuis;Marc Maliepaard

  • Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis

    Thomas P. C. Dorlo;Thomas P. C. Dorlo;Manica Balasegaram;Jos H. Beijnen;Peter J. de Vries

  • Stable isotopically labeled internal standards in quantitative bioanalysis using liquid chromatography/mass spectrometry: necessity or not?

    Ellen Stokvis;Hilde Rosing;Jos H. Beijnen;Jos H. Beijnen

  • A phase I study of the natural killer T-cell ligand alpha-galactosylceramide (KRN7000) in patients with solid tumors.

    Giuseppe Giaccone;Cornelis J. A. Punt;Yoshitaka Ando;Rita Ruijter

  • An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons.

    Esther F.A Brandon;Christiaan D Raap;Irma Meijerman;Jos H Beijnen;Jos H Beijnen

  • Clinical pharmacokinetics of therapeutic monoclonal antibodies.

    Ron J. Keizer;Alwin D. R. Huitema;Jan H. M. Schellens;Jan H. M. Schellens;Jos H. Beijnen;Jos H. Beijnen

  • Approaching tumour therapy beyond platinum drugs : status of the art and perspectives of ruthenium drug candidates.

    A. Bergamo;C. Gaiddon;J.H.M. Schellens;J.H. Beijnen

  • Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein

    G J Zaman;J Lankelma;O van Tellingen;J Beijnen

  • Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs

    J Wijnholds;C A Mol;L van Deemter;M de Haas

  • Clinical Pharmacokinetics of Cyclophosphamide

    Milly E de Jonge;Alwin D R Huitema;Sjoerd Rodenhuis;Jos H Beijnen

  • Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein.

    J. Wijnholds;R. Evers;M. R. Van Leusden;C. A. A. M. Mol

  • Phase I/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy

    Suzanne Leijen;Sjaak A. Burgers;Paul Baas;Dick Pluim

  • Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs.

    Pauline Breedveld;Jos H. Beijnen;Jos H. Beijnen;Jan H.M. Schellens;Jan H.M. Schellens

  • Pharmacokinetics of paclitaxel and metabolites in a randomized comparative study in platinum-pretreated ovarian cancer patients

    M.T. Huizing;A.C.F. Keung;H. Rosing;V. van der Kuij

  • Enhancing antitumor response by combining immune checkpoint inhibitors with chemotherapy in solid tumors

    K.M. Heinhuis;W. Ros;M. Kok;N. Steeghs

  • Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833.

    Ulrich Mayer;Els Wagenaar;Birgit Dorobek;Jos H. Beijnen

Frequent Co-Authors

Jan H.M. Schellens
Jan H.M. Schellens Utrecht University
Hilde Rosing
Hilde Rosing Antoni van Leeuwenhoek Hospital
Alfred H. Schinkel
Alfred H. Schinkel Antoni van Leeuwenhoek Hospital
Sjoerd Rodenhuis
Sjoerd Rodenhuis Antoni van Leeuwenhoek Hospital
David M. Burger
David M. Burger Radboud University
Emile E. Voest
Emile E. Voest Antoni van Leeuwenhoek Hospital
John B. A. G. Haanen
John B. A. G. Haanen Antoni van Leeuwenhoek Hospital
Joep M. A. Lange
Joep M. A. Lange University of Amsterdam
Piet Borst
Piet Borst Antoni van Leeuwenhoek Hospital

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