World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
108
Citations
49734
World Ranking
5941
National Ranking
223

Overview

Alfred H. Schinkel is affiliated with the Antoni van Leeuwenhoek Hospital in the Netherlands. Their research primarily spans the field of Medicine, with notable contributions in several subfields including Oncology, Pharmacology, Molecular Biology, Pediatrics, Perinatology and Child Health, and Pulmonary and Respiratory Medicine.

Their recent publications cover a variety of topics related to drug metabolism, pharmacokinetics, and cancer therapeutics. Notable recent papers include:

  • "The Mechanism-Based Inactivation of CYP3A4 by Ritonavir: What Mechanism?" (2022), published in International Journal of Molecular Sciences
  • "Clinical Pharmacokinetics and Pharmacodynamics of the Cyclin-Dependent Kinase 4 and 6 Inhibitors Palbociclib, Ribociclib, and Abemaciclib" (2020), published in Clinical Pharmacokinetics
  • "Carboxylesterase 1 family knockout alters drug disposition and lipid metabolism" (2022), published in Acta Pharmaceutica Sinica B
  • "The inhibitory and inducing effects of ritonavir on hepatic and intestinal CYP3A and other drug-handling proteins" (2023), published in Biomedicine & Pharmacotherapy
  • "Extrahepatic metabolism of ibrutinib" (2020), published in Investigational New Drugs

The scientist's work is associated with a set of recurring co-authors, reflecting collaborative research efforts. Frequent collaborators include Jos H. Beijnen, Maria C. Lebre, Rolf W. Sparidans, Nancy H.C. Loos, and Hilde Rosing.

Their publications have appeared predominantly in several venues, indicating areas of consistent research output. These venues include:

  • Journal of Chromatography B
  • Biomedicine & Pharmacotherapy
  • Journal of Pharmaceutical and Biomedical Analysis
  • Molecular Pharmaceutics
  • Pharmacological Research

Alfred H. Schinkel's main research topics focus extensively on:

  • Drug Transport and Resistance Mechanisms
  • Pharmacogenetics and Drug Metabolism
  • Cancer therapeutics and mechanisms
  • Pharmacological Effects and Toxicity Studies
  • Chronic Lymphocytic Leukemia Research
  • HIV/AIDS drug development and treatment
  • Advanced Breast Cancer Therapies

Best Publications

  • Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

    A.H. Schinkel;J.J.M. Smit;O. van Tellingen;J.H. Beijnen

  • Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview.

    Alfred H Schinkel;Johan W Jonker

  • P-Glycoprotein, a gatekeeper in the blood-brain barrier.

    Alfred H Schinkel

  • Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

    A. H. Schinkel;U. Mayer;E. Wagenaar;C. A. A. M. Mol

  • Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

    A. Sparreboom;J. van Asperen;U. Mayer;A.H. Schinkel

  • The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria

    Johan W. Jonker;Marije Buitelaar;Els Wagenaar;Martin A. van der Valk

  • Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C.

    John D Allen;Arnold van Loevezijn;Jeany M Lakhai;Martin van der Valk

  • Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study.

    Jacques Fellay;Catia Marzolini;Emma R. Meaden;David J. Back

  • Role of Breast Cancer Resistance Protein in the Bioavailability and Fetal Penetration of Topotecan

    Johan W. Jonker;Johan W. Smit;Remco F. Brinkhuis;Marc Maliepaard

  • The physiological function of drug-transporting P-glycoproteins

    Alfred H. Schinkel

  • Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA.

    R. Evers;M. Kool;L. Van Deemter;H. Janssen

  • Involvement of Organic Cation Transporter 1 in Hepatic and Intestinal Distribution of Metformin

    De-Sheng Wang;Johan W. Jonker;Yukio Kato;Hiroyuki Kusuhara

  • The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin.

    John D. Allen;Remco F. Brinkhuis;Jan Wijnholds;Alfred H. Schinkel

  • The Effect of Bcrp1 (Abcg2) on the In vivo Pharmacokinetics and Brain Penetration of Imatinib Mesylate (Gleevec): Implications for the Use of Breast Cancer Resistance Protein and P-Glycoprotein Inhibitors to Enable the Brain Penetration of Imatinib in Patients

    Pauline Breedveld;Dick Pluim;Greta Cipriani;Peter Wielinga

  • The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk.

    Johan W Jonker;Gracia Merino;Sandra Musters;Antonius E van Herwaarden

  • Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions.

    Giuliano Ciarimboli;Dirk Deuster;Arne Knief;Michael Sperling

  • Pharmacological and Physiological Functions of the Polyspecific Organic Cation Transporters: OCT1, 2, and 3 (SLC22A1-3)

    Johan W. Jonker;Alfred H. Schinkel

  • Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier

    Jan Wijnholds;Elizabeth C.M. de Lange;George L. Scheffer;Dirk-Jan van den Berg

  • Contribution of organic cation transporter 2 (OCT2) to cisplatin-induced nephrotoxicity.

    Kelly K. Filipski;Kelly K. Filipski;Ron H. Mathijssen;Torben S. Mikkelsen;Torben S. Mikkelsen;Alfred H. Schinkel

  • Mice with homozygous disruption of the mdr2 P-glycoprotein gene. A novel animal model for studies of nonsuppurative inflammatory cholangitis and hepatocarcinogenesis.

    Mauad Th;van Nieuwkerk Cm;Dingemans Kp;Smit Jj

Frequent Co-Authors

Jos H. Beijnen
Jos H. Beijnen Utrecht University
Jan H.M. Schellens
Jan H.M. Schellens Utrecht University
Hilde Rosing
Hilde Rosing Antoni van Leeuwenhoek Hospital
Piet Borst
Piet Borst Antoni van Leeuwenhoek Hospital
Ronald P.J. Oude Elferink
Ronald P.J. Oude Elferink University of Amsterdam
Yuichi Sugiyama
Yuichi Sugiyama University of Tokyo
John Allen
John Allen Coventry University
Frank Baas
Frank Baas Leiden University Medical Center
Hiroyuki Kusuhara
Hiroyuki Kusuhara University of Tokyo
John D. Schuetz
John D. Schuetz St. Jude Children's Research Hospital

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring alternative and complementary healthcare degrees online can help you reach your career goals faster and with greater flexibility. Many students interested in medicine start with practical, entry-level certifications, such as those offered by fast track medical programs. These accelerated options allow you to quickly enter the workforce as a licensed professional and gain hands-on experience.

For those seeking specialization, advanced nursing paths like the fastest psych np program can be completed online and often in less time than traditional options. This lets you build expertise in mental health while maintaining flexibility.

If you're drawn to leadership roles, there are healthcare administration degrees available that prepare you for management positions. For graduates pursuing top administrative roles, an affordable mha online can make career advancement accessible and budget-friendly.

Overall, online healthcare degrees offer a range of pathways for students with different interests, from clinical practice to leadership. Research your options to find a program that matches your professional ambitions and lifestyle.

Best Scientists Citing Alfred H. Schinkel

Trending Scientists

Recently Published Articles