What is he best known for?
The fields of study he is best known for:
- Enzyme
- Gene
- Internal medicine
His primary scientific interests are in Pharmacology, P-glycoprotein, Abcg2, ATP-binding cassette transporter and Internal medicine.
His biological study spans a wide range of topics, including CYP3A and In vivo.
His studies deal with areas such as Biochemistry, Blood–brain barrier and Transfection as well as P-glycoprotein.
Alfred H. Schinkel has included themes like Carcinogen, Secretion, Lactation, Vitamin and Drug resistance in his Abcg2 study.
His ATP-binding cassette transporter study incorporates themes from Multiple drug resistance, Topotecan and Doxorubicin.
His research in Internal medicine intersects with topics in Endocrinology and Hepatocyte.
His most cited work include:
- Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs (1972 citations)
- Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. (1230 citations)
- Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins (834 citations)
What are the main themes of his work throughout his whole career to date?
His primary areas of investigation include Pharmacology, P-glycoprotein, Pharmacokinetics, Abcg2 and In vivo.
The study incorporates disciplines such as Toxicity, CYP3A and Multidrug resistance-associated protein 2, ATP-binding cassette transporter in addition to Pharmacology.
His study in P-glycoprotein is interdisciplinary in nature, drawing from both Transgene, Molecular biology, Blood–brain barrier and Transfection.
His Pharmacokinetics study combines topics in areas such as Selected reaction monitoring, Bioavailability, Endocrinology and Chromatography.
His Abcg2 study integrates concerns from other disciplines, such as Efflux, Knockout mouse, Tyrosine-kinase inhibitor and Carcinogen.
Alfred H. Schinkel interconnects Metabolite, Genetically modified mouse, In vitro and Methotrexate in the investigation of issues within In vivo.
He most often published in these fields:
- Pharmacology (52.61%)
- P-glycoprotein (32.53%)
- Pharmacokinetics (32.13%)
What were the highlights of his more recent work (between 2017-2021)?
- Pharmacokinetics (32.13%)
- Pharmacology (52.61%)
- Chromatography (13.25%)
In recent papers he was focusing on the following fields of study:
His main research concerns Pharmacokinetics, Pharmacology, Chromatography, Bioanalysis and Protein precipitation.
As a part of the same scientific family, Alfred H. Schinkel mostly works in the field of Pharmacokinetics, focusing on Oral administration and, on occasion, Bioavailability and Distribution.
His Pharmacology research includes elements of P-glycoprotein, Abcg2, CYP3A4, CYP3A and Genetically modified mouse.
Alfred H. Schinkel works mostly in the field of P-glycoprotein, limiting it down to concerns involving In vivo and, occasionally, FLT3 Inhibitor.
In Bioanalysis, Alfred H. Schinkel works on issues like Analyte, which are connected to Extraction.
As a member of one scientific family, he mostly works in the field of Organic anion-transporting polypeptide, focusing on Endocrinology and, on occasion, Internal medicine.
Between 2017 and 2021, his most popular works were:
- Cytochrome P450 3A4, 3A5, and 2C8 expression in breast, prostate, lung, endometrial, and ovarian tumors : relevance for resistance to taxanes (15 citations)
- Development and validation of a bioanalytical method for the quantification of the CDK4/6 inhibitors abemaciclib, palbociclib, and ribociclib in human and mouse matrices using liquid chromatography-tandem mass spectrometry. (15 citations)
- P-glycoprotein (MDR1/ABCB1) restricts brain accumulation and cytochrome P450-3A (CYP3A) limits oral availability of the novel ALK/ROS1 inhibitor lorlatinib (11 citations)
In his most recent research, the most cited papers focused on:
Alfred H. Schinkel focuses on Pharmacokinetics, Bioanalysis, Chromatography, Abcg2 and Transgene.
His studies deal with areas such as Selected reaction monitoring, Liquid chromatography–mass spectrometry and Protein precipitation as well as Bioanalysis.
Alfred H. Schinkel has included themes like P-glycoprotein, Blood–brain barrier, Gene knockout, CYP3A and Genetically modified mouse in his Abcg2 study.
His P-glycoprotein research is multidisciplinary, incorporating perspectives in Toxicity and Oral administration, Bioavailability, Pharmacology.
His Pharmacology study frequently draws connections between adjacent fields such as CYP3A4.
His Transgene research is multidisciplinary, relying on both Cancer research, Knockout mouse and Tyrosine-kinase inhibitor.
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