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Biology and Biochemistry

D-Index
97
Citations
36740
World Ranking
1743
National Ranking
970

Overview

Suresh V. Ambudkar is affiliated with the National Institutes of Health in the United States. Their research centers primarily on medicine and biochemistry, genetics, and molecular biology, with a substantial focus on oncology and molecular biology as subfields. Their scholarly contributions encompass areas such as drug transport and resistance mechanisms, cancer therapeutics, HIV/AIDS drug development, RNA interference, pharmacology, microRNA in disease regulation, and trace elements in health.

The scientist has a prolific publication record, with frequent contributions to several key journals. These include:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • International Journal of Molecular Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Drug Resistance Updates
  • Cancers

Collaboration is a significant aspect of their work, with frequent co-authors such as:

  • Megumi Murakami
  • Sabrina Lusvarghi
  • Chung-Pu Wu
  • Tai-Ho Hung
  • Yang-Hui Huang

Recent papers by the scientist address topics related to drug resistance, cancer therapeutics, and molecular mechanisms. Representative publications include:

  • Advances in the structure, mechanism and targeting of chemoresistance-linked ABC transporters (2023, Nature Reviews. Cancer)
  • Emerging nanotechnology-based therapeutics to combat multidrug-resistant cancer (2022, Journal of Nanobiotechnology)
  • Natural medicinal compounds target signal transduction pathways to overcome ABC drug efflux transporter-mediated multidrug resistance in cancer (2023, Drug Resistance Updates)
  • Characterization and tissue localization of zebrafish homologs of the human ABCB1 multidrug transporter (2021, Scientific Reports)
  • Tivantinib, A c-Met Inhibitor in Clinical Trials, Is Susceptible to ABCG2-Mediated Drug Resistance (2020, Cancers)

Their work contributes to understanding mechanisms of multidrug resistance in cancer, including studies on ABC transporters and therapeutic strategies to address chemoresistance. The integration of nanotechnology and natural medicinal compounds into these studies reflects a multidisciplinary approach within biomedical research.

Best Publications

  • A "Silent" Polymorphism in the MDR1 Gene Changes Substrate Specificity

    Chava Kimchi-Sarfaty;Jung Mi Oh;In-Wha Kim;Zuben E. Sauna

  • Biochemical, cellular, and pharmacological aspects of the multidrug transporter

    Suresh V. Ambudkar;Saibal Dey;Christine A. Hrycyna;Muralidhara Ramachandra

  • P-glycoprotein: from genomics to mechanism

    Suresh V Ambudkar;Chava Kimchi-Sarfaty;Zuben E Sauna;Michael M Gottesman

  • Brca1 breast tumors contain distinct CD44+/CD24- and CD133+ cells with cancer stem cell characteristics

    Mollie H Wright;Anna Maria Calcagno;Crystal D Salcido;Marisa D Carlson

  • Reconstitution of functional water channels in liposomes containing purified red cell CHIP28 protein.

    Mark L. Zeidel;Suresh V. Ambudkar;Barbara L. Smith;Peter Agre

  • P-glycoprotein and multidrug resistance.

    Michael M Gottesman;Ira Pastan;Suresh V Ambudkar

  • HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.

    Caroline G. L. Lee;Michael M. Gottesman;Carol O. Cardarelli;Muralidhara Ramachandra

  • Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity

    Joseph Tam;V. Kiran Vemuri;Jie Liu;Sándor Bátkai

  • Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance

    Jean Pierre Gillet;Anna Maria Calcagno;Sudhir Varma;Miguel Marino

  • Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis.

    Suresh V. Ambudkar;Isabelle H. Lelong;Jiaping Zhang;Carol O. Cardarelli

  • Overview: ABC transporters and human disease.

    Michael M. Gottesman;Suresh V. Ambudkar

  • Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

    Saibal Dey;Muralidhara Ramachandra;Ira Pastan;Michael M. Gottesman

  • Lapatinib (Tykerb, GW572016) Reverses Multidrug Resistance in Cancer Cells by Inhibiting the Activity of ATP-Binding Cassette Subfamily B Member 1 and G Member 2

    Chun Ling Dai;Amit K. Tiwari;Chung Pu Wu;Xiao Dong Su

  • Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells.

    Songyot Anuchapreeda;Pranee Leechanachai;Melissa M. Smith;Suresh V. Ambudkar

  • Apatinib (YN968D1) Reverses Multidrug Resistance by Inhibiting the Efflux Function of Multiple ATP-Binding Cassette Transporters

    Yan Jun Mi;Yong Ju Liang;Hong Bing Huang;Hong Yun Zhao

  • Human P-Glycoprotein Exhibits Reduced Affinity for Substrates during a Catalytic Transition State †

    Muralidhara Ramachandra;Suresh V. Ambudkar;David Chen;Christine A. Hrycyna

  • Erlotinib (Tarceva, OSI-774) Antagonizes ATP-Binding Cassette Subfamily B Member 1 and ATP-Binding Cassette Subfamily G Member 2–Mediated Drug Resistance

    Zhi Shi;Xing Xiang Peng;In Wha Kim;Suneet Shukla

  • Silent Polymorphisms Speak: How They Affect Pharmacogenomics and the Treatment of Cancer

    Zuben E. Sauna;Chava Kimchi-Sarfaty;Suresh V. Ambudkar;Michael M. Gottesman

  • Prolonged Drug Selection of Breast Cancer Cells and Enrichment of Cancer Stem Cell Characteristics

    Anna Maria Calcagno;Crystal D. Salcido;Jean Pierre Gillet;Chung Pu Wu

  • Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein

    Zuben E. Sauna;Suresh V. Ambudkar

Frequent Co-Authors

Michael M. Gottesman
Michael M. Gottesman National Institutes of Health
Zhe-Sheng Chen
Zhe-Sheng Chen St. John's University
Susan E. Bates
Susan E. Bates Columbia University
Ira Pastan
Ira Pastan Center for Cancer Research
Matthew D. Hall
Matthew D. Hall National Institutes of Health
Rajendra Prasad
Rajendra Prasad Amity University
Maria R. Baer
Maria R. Baer University of Maryland, Baltimore
Craig J. Thomas
Craig J. Thomas National Institutes of Health
Stuart H. Yuspa
Stuart H. Yuspa National Institutes of Health
Ben Davidson
Ben Davidson Oslo University Hospital

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