His scientific interests lie mostly in Pharmacology, Multiple drug resistance, Cancer, Biochemistry and Drug. His studies in Pharmacology integrate themes in fields like Cell culture, Abcg2, Efflux, Antifolate and Multidrug resistance-associated protein 2. His study in Antifolate is interdisciplinary in nature, drawing from both Transporter and Dihydrofolate reductase.
The Multiple drug resistance study combines topics in areas such as Cancer cell, Lipid bilayer and Liposome. His work carried out in the field of Cancer brings together such families of science as Precision medicine, Apoptosis, Drug resistance and Intracellular. In his research, ATPase, Peripheral blood mononuclear cell and Carfilzomib is intimately related to P-glycoprotein, which falls under the overarching field of Biochemistry.
His main research concerns Cancer research, Pharmacology, Biochemistry, Antifolate and Multiple drug resistance. He interconnects Cancer, Leukemia, Immunology, Bortezomib and Drug resistance in the investigation of issues within Cancer research. The study incorporates disciplines such as Cell culture, Transporter, Abcg2 and Multidrug resistance-associated protein 2 in addition to Pharmacology.
His Antifolate research incorporates themes from Molecular biology and Dihydrofolate reductase. The concepts of his Molecular biology study are interwoven with issues in Proteasome inhibitor, Mutation, Gene silencing, Gene and Membrane transport protein. His Multiple drug resistance study incorporates themes from Cancer cell and Efflux.
Yehuda G. Assaraf spends much of his time researching Cancer research, Cancer, Drug resistance, Multiple drug resistance and Cancer cell. His Cancer research study combines topics in areas such as Tumor microenvironment, Pemetrexed, Paclitaxel, Lung cancer and Drug. His research integrates issues of Extracellular, Cytoplasm and Homeostasis in his study of Cancer.
His Multiple drug resistance study combines topics from a wide range of disciplines, such as ATP-binding cassette transporter, Efflux, Endoplasmic reticulum, Membrane fluidity and Casein micelles. His Efflux research is included under the broader classification of Biochemistry. His biological study spans a wide range of topics, including Targeted therapy and Computational biology.
Yehuda G. Assaraf focuses on Cancer research, Drug resistance, Cancer, Multiple drug resistance and Cancer cell. He has included themes like Acute myeloblastic leukemia, Cancer therapy and Lung cancer in his Cancer research study. Yehuda G. Assaraf works mostly in the field of Drug resistance, limiting it down to topics relating to microRNA and, in certain cases, Long non-coding RNA, Anticancer drug and Cancer drugs, as a part of the same area of interest.
His studies deal with areas such as Receptor-mediated endocytosis and A549 cell as well as Cancer. In his research on the topic of Multiple drug resistance, Tariquidar, Mitochondrion, Organelle localization and P-glycoprotein is strongly related with Efflux. His Cancer cell research integrates issues from HeLa, Internalization, Targeted drug delivery and Endocytosis.
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Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2.
Jan Hendrik Hooijberg;Henk J. Broxterman;Marcel Kool;Yehuda G. Assaraf.
Cancer Research (1999)
Molecular basis of bortezomib resistance: proteasome subunit beta5 (PSMB5) gene mutation and overexpression of PSMB5 protein
Ruud Oerlemans;Niels E. Franke;Yehuda G. Assaraf;Jacqueline Cloos.
Nanomedicine for targeted cancer therapy: Towards the overcoming of drug resistance
Alina Shapira;Yoav D. Livney;Henk J. Broxterman;Yehuda G. Assaraf.
Drug Resistance Updates (2011)
Molecular basis of antifolate resistance.
Yehuda G. Assaraf.
Cancer and Metastasis Reviews (2007)
Antifolates in cancer therapy: structure, activity and mechanisms of drug resistance.
Nitzan Gonen;Yehuda G. Assaraf.
Drug Resistance Updates (2012)
Lysosomal sequestration of sunitinib: a novel mechanism of drug resistance
Kristy J. Gotink;Henk J. Broxterman;Mariette Labots;Richard R. de Haas.
Clinical Cancer Research (2011)
Overcoming ABC transporter-mediated multidrug resistance: Molecular mechanisms and novel therapeutic drug strategies
Wen Li;Han Zhang;Yehuda G. Assaraf;Kun Zhao.
Drug Resistance Updates (2016)
The folate receptor as a rational therapeutic target for personalized cancer treatment
Yehuda G. Assaraf;Christopher P. Leamon;Joseph A. Reddy.
Drug Resistance Updates (2014)
The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis.
Yehuda G. Assaraf.
Drug Resistance Updates (2006)
Lysosomes as mediators of drug resistance in cancer.
Benny Zhitomirsky;Yehuda G. Assaraf.
Drug Resistance Updates (2016)
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