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Biology and Biochemistry

D-Index
59
Citations
12030
World Ranking
12572
National Ranking
5376

Overview

I. David Goldman is affiliated with the Albert Einstein College of Medicine in the United States. Their research primarily focuses on biochemical and molecular processes related to folate metabolism and its genetic and molecular regulation, intersecting with areas of medicine and molecular biology.

Their main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

The subfields of their work highlight specific interests in:

  • Molecular Biology
  • Rheumatology
  • Nutrition and Dietetics

Goldman's research topics cover several areas, notably:

  • Folate and B Vitamins Research
  • RNA modifications and cancer
  • RNA regulation and disease
  • Trace Elements in Health
  • Porphyrin Metabolism and Disorders

Their recent publications consist of detailed studies on proton-coupled folate transporters and hereditary folate malabsorption, illustrating a focus on protein structure and mutation effects in folate biology. Selected papers include:

  • "Structural basis of antifolate recognition and transport by PCFT," 2021, published in Nature
  • "A proton-coupled folate transporter mutation causing hereditary folate malabsorption locks the protein in an inward-open conformation," 2020, published in Journal of Biological Chemistry
  • "Mechanistic insights into mutation in the proton-coupled folate transporter (SLC46A1) causing hereditary folate malabsorption," 2025, published in Journal of Biological Chemistry

The venues where Goldman frequently publishes include:

  • Journal of Biological Chemistry
  • Nature

Frequent collaboration partners in their research endeavors are:

  • András Fiser
  • Joanne L. Parker
  • Justin C. Deme
  • Gabriel Kuteyi
  • Zhiyi Wu

Best Publications

  • Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption.

    Andong Qiu;Michaela Jansen;Antoinette Sakaris;Sang Hee Min

  • Membrane transport of folates.

    Larry H. Matherly;I. David Goldman

  • Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues.

    Rongbao Zhao;Larry H. Matherly;I. David Goldman

  • Mechanisms of Membrane Transport of Folates into Cells and Across Epithelia

    Rongbao Zhao;Ndeye Diop-Bove;Michele Visentin;I. David Goldman

  • Resistance to antifolates.

    Rongbao Zhao;I David Goldman

  • The cellular pharmacology of methotrexate

    I.David Goldman;Larry H. Matherly

  • Schedule-dependent cytotoxic synergism of pemetrexed and erlotinib in human non-small cell lung cancer cells.

    Tianhong Li;Yi He Ling;I. David Goldman;Roman Perez-Soler

  • The Intestinal Absorption of Folates

    Michele Visentin;Ndeye Diop-Bove;Rongbao Zhao;I. David Goldman

  • Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors.

    Rongbao Zhao;I. David Goldman

  • Rapid catabolism of 5-fluorouracil in freshly isolated rat hepatocytes as analyzed by high performance liquid chromatography

    J P Sommadossi;D A Gewirtz;R B Diasio;C Aubert

  • The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorption

    Rongbao Zhao;Sang Hee Min;Andong Qiu;Antoinette Sakaris

  • SLC19A3 encodes a second thiamine transporter ThTr2

    Arun Rajgopal;Antoinette Edmondnson;I.David Goldman;Rongbao Zhao

  • Localization of the murine reduced folate carrier as assessed by immunohistochemical analysis.

    Yanhua Wang;Rongbao Zhao;Robert G Russell;I.David Goldman

  • Rescue of embryonic lethality in reduced folate carrier-deficient mice by maternal folic acid supplementation reveals early neonatal failure of hematopoietic organs.

    Rongbao Zhao;Robert G. Russell;Yanhua Wang;Laibin Liu

  • A role for the proton-coupled folate transporter (PCFT - SLC46A1) in folate receptor-mediated endocytosis

    Rongbao Zhao;Sang Hee Min;Yanhua Wang;Estela Campanella

  • The Concise Guide to PHARMACOLOGY 2013/14: overview

    Stephen P.H. Alexander;Helen E. Benson;Elena Faccenda;Adam J. Pawson

  • The Proton-Coupled Folate Transporter: Impact on Pemetrexed Transport and on Antifolates Activities Compared with the Reduced Folate Carrier

    Rongbao Zhao;Andong Qiu;Eugenia Tsai;Michaela Jansen

  • Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction.

    Andong Qiu;Sang Hee Min;Michaela Jansen;Usha Malhotra

  • Reduced folate carrier transports thiamine monophosphate: an alternative route for thiamine delivery into mammalian cells.

    Rongbao Zhao;Feng Gao;I. David Goldman

  • The molecular identity and characterization of a Proton-coupled Folate Transporter--PCFT; biological ramifications and impact on the activity of pemetrexed.

    Rongbao Zhao;I. David Goldman

Frequent Co-Authors

Andras Fiser
Andras Fiser Albert Einstein College of Medicine
Yehuda G. Assaraf
Yehuda G. Assaraf Technion – Israel Institute of Technology
Larry H. Matherly
Larry H. Matherly Wayne State University
Myles H. Akabas
Myles H. Akabas Albert Einstein College of Medicine
Gerrit Jansen
Gerrit Jansen Amsterdam UMC
Richard H. Finnell
Richard H. Finnell Baylor College of Medicine
Vern L. Schramm
Vern L. Schramm Albert Einstein College of Medicine
Bruce D. Gelb
Bruce D. Gelb Icahn School of Medicine at Mount Sinai
Winfried Edelmann
Winfried Edelmann Albert Einstein College of Medicine

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