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Christopher P. Leamon

Christopher P. Leamon

Overview

Christopher P. Leamon is affiliated with Fusion Pharmaceuticals in the United States. Their research primarily spans the medical field with a focus on Radiology, Nuclear Medicine and Imaging, Oncology, Molecular Biology, Immunology, and Public Health, Environmental and Occupational Health.

The scientist's work covers various topics including:

  • Radiopharmaceutical Chemistry and Applications
  • Autoimmune and Inflammatory Disorders Research
  • Immune Cell Function and Interaction
  • Acute Lymphoblastic Leukemia research
  • Genomic variations and chromosomal abnormalities
  • Cancer-related Molecular Pathways
  • DNA and Nucleic Acid Chemistry

Christopher P. Leamon has contributed to several publications over recent years. Notable papers include:

  • Targeting folate receptor beta on monocytes/macrophages renders rapid inflammation resolution independent of root causes, 2021, Cell Reports Medicine
  • Pre-clinical studies of EC2629, a highly potent folate-receptor-targeted DNA crosslinking agent, 2020, Scientific Reports
  • Design and synthesis of a folate-receptor targeted diazepine-ring-opened pyrrolobenzodiazepine prodrug conjugate, 2020, Bioorganic & Medicinal Chemistry Letters
  • A Novel Treatment for Glomerular Disease: Targeting the Activated Macrophage Folate Receptor with a Trojan Horse Therapy in Rats, 2021, Cells
  • Abstract 5045: NTSR1-targeted alpha therapeutic [Ac-225]-FPI-2059 induces growth inhibition in a preclinical colorectal tumor model, 2023, Cancer Research

Frequent co-authors include:

  • John F. Valliant (4 publications)
  • Iontcho R. Vlahov (3 publications)
  • Brigitte L. Thériault (3 publications)
  • Yingjuan Lu (2 publications)
  • Paul J. Kleindl (2 publications)

Their research has appeared predominantly in the following journals:

  • Cancer Research (4 publications)
  • Cell Reports Medicine (1 publication)
  • Scientific Reports (1 publication)
  • Bioorganic & Medicinal Chemistry Letters (1 publication)
  • Cells (1 publication)

Best Publications

  • Delivery of macromolecules into living cells: a method that exploits folate receptor endocytosis.

    Christopher P. Leamon;Philip S. Low

  • Folate-targeted chemotherapy

    Christopher P Leamon;Joseph A Reddy

  • Synthesis and biological evaluation of EC20: a new folate-derived, (99m)Tc-based radiopharmaceutical.

    Christopher P Leamon;Matthew A Parker;Iontcho R Vlahov;Le-Cun Xu

  • Ligand Binding and Kinetics of Folate Receptor Recycling in Vivo: Impact on Receptor-Mediated Drug Delivery

    Chrystal M. Paulos;Joseph A. Reddy;Christopher P. Leamon;Mary Jo Turk

  • Engineering folate-drug conjugates to target cancer: from chemistry to clinic.

    Iontcho R. Vlahov;Christopher P. Leamon

  • Folate-liposome-mediated antisense oligodeoxynucleotide targeting to cancer cells: evaluation in vitro and in vivo.

    Christopher P Leamon;Scott R Cooper;Gregory E Hardee

  • Endocytosis of folate-protein conjugates: Ultrastructural localization in KB cells

    John J. Turek;Christopher P. Leamon;Philip S. Low

  • Cytotoxicity of folate-Pseudomonas exotoxin conjugates toward tumor cells. Contribution of translocation domain.

    Christopher P. Leamon;Ira Pastan;Philip Low

  • Folate-targeted, cationic liposome-mediated gene transfer into disseminated peritoneal tumors.

    J A Reddy;C Abburi;H Hofland;S J Howard

  • Cytotoxicity of momordin-folate conjugates in cultured human cells.

    C. P. Leamon;Philip Low

  • Membrane folate-binding proteins are responsible for folate-protein conjugate endocytosis into cultured cells

    C P Leamon;P S Low

  • Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part 1: EC145, a folic acid conjugate of desacetylvinblastine monohydrazide

    Iontcho R. Vlahov;Hari Krishna R. Santhapuram;Paul J. Kleindl;Stephen J. Howard

  • Preclinical Evaluation of 99mTc-EC20 for Imaging Folate Receptor–Positive Tumors

    Joseph A. Reddy;Le-Cun Xu;Nikki Parker;Marilynn Vetzel

  • Synthesis and biological evaluation of EC72: a new folate-targeted chemotherapeutic.

    Christopher P. Leamon;Joseph A. Reddy;Iontcho R. Vlahov;Marilynn Vetzel

  • Method for tumor imaging and composition

    Philip Stewart Low;ロウ,フィリップ,スチュワート;Mark A Green;グリーン,マーク,エー.

  • Folate mimetics and folate-receptor binding conjugates thereof

    Mark A. Green;Chun-Yen Ke;Christopher P. Leamon

  • Vitamin receptor binding drug delivery conjugates

    Iontcho Radoslavov Vlahov;Christopher Paul Leamon;Matthew A. Parker;Stephen J. Howard

  • Comparative preclinical activity of the folate-targeted Vinca alkaloid conjugates EC140 and EC145.

    Christopher P. Leamon;Joseph A. Reddy;Iontcho R. Vlahov;Elaine Westrick

  • Folate receptor specific anti-tumor activity of folate-mitomycin conjugates.

    Joseph A. Reddy;Elaine Westrick;Iontcho Vlahov;Stephen J. Howard

  • Fusogenic lipids and vesicles

    Christopher Paul Leamon

Frequent Co-Authors

Philip S. Low
Philip S. Low Purdue University West Lafayette
Haiyan Chu
Haiyan Chu Endocyte (United States)
Roger Schibli
Roger Schibli ETH Zurich
Kevin K. W. Wang
Kevin K. W. Wang Morehouse School of Medicine
Larry H. Matherly
Larry H. Matherly Wayne State University
Robert J. Lee
Robert J. Lee University of Pennsylvania
Emmett V. Schmidt
Emmett V. Schmidt MSD (United States)
Francois Villinger
Francois Villinger University of Louisiana at Lafayette
Yehuda G. Assaraf
Yehuda G. Assaraf Technion – Israel Institute of Technology
Gerrit Jansen
Gerrit Jansen Amsterdam UMC

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