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Gerrit Jansen

Gerrit Jansen

D-Index & Metrics

Biology and Biochemistry

D-Index
74
Citations
15725
World Ranking
5740
National Ranking
142

Overview

Gerrit Jansen is affiliated with Amsterdam UMC in the Netherlands and has contributed extensively to the field of medicine, with a focus on several subfields including rheumatology, molecular biology, immunology, oncology, and public health. Their body of research spans a range of topics, prominently addressing rheumatoid arthritis, acute lymphoblastic leukemia, systemic lupus erythematosus, autoimmune and inflammatory disorders, immune cells in cancer, RNA modifications and cancer, and RNA research and splicing.

Among their recent publications are several papers that reflect this broad scope of investigation. Notable papers include:

  • The role of alternative splicing in cancer: From oncogenesis to drug resistance, 2020, Drug Resistance Updates
  • First in man study of [18F]fluoro-PEG-folate PET: a novel macrophage imaging technique to visualize rheumatoid arthritis, 2020, Scientific Reports
  • Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds, 2020, British Journal of Cancer
  • Patient-derived oral mucosa organoids as an in vitro model for methotrexate induced toxicity in pediatric acute lymphoblastic leukemia, 2020, PLoS ONE
  • Identification of Metabolic Biomarkers in Relation to Methotrexate Response in Early Rheumatoid Arthritis, 2020, Journal of Personalized Medicine

Jansen has frequently published in venues such as Annals of the Rheumatic Diseases, Frontiers in Immunology, Resuscitation, Scientific Reports, and PLoS ONE. These journals cover a mixture of clinical and biomedical research, highlighting the multidisciplinary nature of their work.

The scientist has collaborated often with several co-authors, indicating a network of recurring partnerships in their research projects. Frequent co-authors include Róbert de Jonge, Jacqueline Cloos, Marry Lin, Ittai B. Muller, and Conny J. van der Laken.

Primary research topics covered by Jansen encompass:

  • Rheumatoid Arthritis Research and Therapies
  • Acute Lymphoblastic Leukemia research
  • Systemic Lupus Erythematosus Research
  • Autoimmune and Inflammatory Disorders Research
  • Immune cells in cancer
  • RNA modifications and cancer
  • RNA Research and Splicing

Overall, Gerrit Jansen's contributions lie at the intersection of clinical medicine and molecular biology, with a distinct emphasis on understanding disease mechanisms and therapeutic responses related to autoimmune diseases and cancer.

Best Publications

  • Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2.

    Jan Hendrik Hooijberg;Henk J. Broxterman;Marcel Kool;Yehuda G. Assaraf

  • Molecular basis of bortezomib resistance: proteasome subunit beta5 (PSMB5) gene mutation and overexpression of PSMB5 protein

    Ruud Oerlemans;Niels E. Franke;Yehuda G. Assaraf;Jacqueline Cloos

  • Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism

    G.J Peters;H.H.J Backus;S Freemantle;B van Triest

  • Lysosomal sequestration of sunitinib: a novel mechanism of drug resistance

    Kristy J. Gotink;Henk J. Broxterman;Mariette Labots;Richard R. de Haas

  • Peroxisomal fatty acid alpha- and beta-oxidation in humans: enzymology, peroxisomal metabolite transporters and peroxisomal diseases.

    R. J. A. Wanders;P. Vreken;S. Ferdinandusse;G. A. Jansen

  • Drug resistance in pancreatic cancer: Impact of altered energy metabolism.

    Cristoforo Grasso;Gerrit Jansen;Elisa Giovannetti;Elisa Giovannetti

  • Polymorphisms in folate-related genes and risk of pediatric acute lymphoblastic leukemia.

    Robert de Jonge;Wim J. E. Tissing;Wim J. E. Tissing;Jan Hendrik Hooijberg;Gerrit Jansen

  • Impaired bortezomib binding to mutant beta 5 subunit of the proteasome is the underlying basis for bortezomib resistance in leukemia cells.

    N E Franke;D Niewerth;Y G Assaraf;J van Meerloo

  • Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines.

    B. Van Triest;H. M. Pinedo;Y. Van Hensbergen;K. Smid

  • Induction of resistance to the multitargeted antifolate Pemetrexed (ALIMTA) in WiDr human colon cancer cells is associated with thymidylate synthase overexpression

    Jennifer Sigmond;Harold H.J. Backus;Dorine Wouters;Olaf H. Temmink

  • A Structurally Altered Human Reduced Folate Carrier with Increased Folic Acid Transport Mediates a Novel Mechanism of Antifolate Resistance

    Gerrit Jansen;Robert Mauritz;Stavit Drori;Hannah Sprecher

  • Different drug sensitivity profiles of acute myeloid and lymphoblastic leukemia and normal peripheral blood mononuclear cells in children with and without Down syndrome

    Christian M Zwaan;Gertjan J L Kaspers;Rob Pieters;Karel Hählen

  • Folate receptor beta as a potential delivery route for novel folate antagonists to macrophages in the synovial tissue of rheumatoid arthritis patients.

    Joost W. Van Der Heijden;Ruud Oerlemans;Ben A. C. Dijkmans;Huiling Qi

  • Molecular basis of resistance to proteasome inhibitors in hematological malignancies

    Denise Niewerth;Gerrit Jansen;Yehuda G. Assaraf;Sonja Zweegman

  • The role of alternative splicing in cancer: From oncogenesis to drug resistance.

    Rocco Sciarrillo;Anna Wojtuszkiewicz;Yehuda G. Assaraf;Gerrit Jansen

  • Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia.

    Marianne G. Rots;Marianne G. Rots;Rob Pieters;Rob Pieters;Godefridus J. Peters;Godefridus J. Peters;Paul Noordhuis;Paul Noordhuis

  • In vitro and in vivo antitumor activity of methotrexate conjugated to human serum albumin in human cancer cells

    Katja Wosikowski;Elfi Biedermann;Benno Rattel;Norbert Breiter

  • The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates.

    Peter Wielinga;Jan Hendrik Hooijberg;Sjofn Gunnarsdottir;Ietje Kathmann

  • Bortezomib resistance in multiple myeloma is associated with increased serine synthesis

    Esther A. Zaal;Wei Wu;Gerrit Jansen;Sonja Zweegman

  • Drug Insight: resistance to methotrexate and other disease-modifying antirheumatic drugs--from bench to bedside.

    Joost W van der Heijden;Ben A C Dijkmans;Rik J Scheper;Gerrit Jansen

Frequent Co-Authors

Yehuda G. Assaraf
Yehuda G. Assaraf Technion – Israel Institute of Technology
Godefridus J. Peters
Godefridus J. Peters Gdańsk Medical University
George L. Scheffer
George L. Scheffer VU University Medical Center
Willem F. Lems
Willem F. Lems Vrije Universiteit Amsterdam
Sonja Zweegman
Sonja Zweegman Amsterdam UMC
Rik J. Scheper
Rik J. Scheper Amsterdam University Medical Centers
Ben A. C. Dijkmans
Ben A. C. Dijkmans Amsterdam UMC
Marianne G. Rots
Marianne G. Rots University Medical Center Groningen
Adriaan A. Lammertsma
Adriaan A. Lammertsma VU University Medical Center

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