His main research concerns Multiple drug resistance, ATP-binding cassette transporter, Pharmacology, Efflux and Biochemistry. His Multiple drug resistance research is multidisciplinary, incorporating elements of Molecular biology, Multidrug Resistance-Associated Proteins and Cell culture. The various areas that he examines in his ATP-binding cassette transporter study include P-glycoprotein and Intracellular.
His studies in Pharmacology integrate themes in fields like Paclitaxel, Chemotherapy, Cancer cell, Tyrosine kinase and Tyrosine-kinase inhibitor. His work deals with themes such as Cancer research, Abcg2 and Nilotinib, which intersect with Tyrosine-kinase inhibitor. His Efflux study integrates concerns from other disciplines, such as ABCC6, Membrane protein, Membrane transport and Multidrug resistance-associated protein 2.
Zhe-Sheng Chen focuses on Multiple drug resistance, Pharmacology, Efflux, ATP-binding cassette transporter and Cancer research. His work carried out in the field of Multiple drug resistance brings together such families of science as Cancer cell, Abcg2 and Intracellular. His Pharmacology research is multidisciplinary, relying on both Paclitaxel, ABCC1, Doxorubicin, Tyrosine-kinase inhibitor and In vivo.
He works mostly in the field of Efflux, limiting it down to concerns involving Molecular biology and, occasionally, Cell culture, Transfection and Epidermoid carcinoma. His ATP-binding cassette transporter research incorporates themes from Tyrosine kinase and Subfamily. Zhe-Sheng Chen interconnects Cancer, Cell cycle and Apoptosis in the investigation of issues within Cancer research.
His primary scientific interests are in Multiple drug resistance, Cancer research, Abcg2, Cancer cell and Efflux. His biological study spans a wide range of topics, including Transporter, ATP-binding cassette transporter, Intracellular, Cytotoxicity and Pharmacology. His studies deal with areas such as Computational biology and Transfection as well as ATP-binding cassette transporter.
His Cancer research study combines topics from a wide range of disciplines, such as Cancer, Colorectal cancer, Cell cycle and Drug resistance. The study incorporates disciplines such as Molecular biology, Cell and Clinical trial in addition to Cancer cell. His Efflux study combines topics in areas such as IC50, P-glycoprotein, ABCC10 and Protein kinase A.
His primary areas of study are Multiple drug resistance, Cancer research, Cancer cell, Drug resistance and Cancer. His Multiple drug resistance research incorporates elements of Transporter, Abcg2, ATP-binding cassette transporter, Efflux and MTT assay. His Efflux research includes elements of Clinical trial and Chemotherapy.
Zhe-Sheng Chen usually deals with Cancer cell and limits it to topics linked to PI3K/AKT/mTOR pathway and Downregulation and upregulation, Epidermoid carcinoma and Protein kinase B. His Cancer research includes themes of Anticancer drug, Disulfiram, Drug, Pharmacology and Safety profile. His study looks at the relationship between Pharmacology and fields such as Malaria, as well as how they intersect with chemical problems.
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Biosynthesis of nanoparticles by microorganisms and their applications
Xiangqian Li;Huizhong Xu;Zhe-Sheng Chen;Guofang Chen.
Journal of Nanomaterials (2011)
Silver nanoparticles: synthesis, properties, and therapeutic applications.
Liuya Wei;Jingran Lu;Huizhong Xu;Atish Patel.
Drug Discovery Today (2015)
The modulation of ABC transporter-mediated multidrug resistance in cancer: a review of the past decade.
Rishil J. Kathawala;Pranav Gupta;Charles R. Ashby;Zhe-Sheng Chen.
Drug Resistance Updates (2015)
The development of anticancer ruthenium(II) complexes: from single molecule compounds to nanomaterials
Leli Zeng;Leli Zeng;Pranav Gupta;Yanglu Chen;Enju Wang.
Chemical Society Reviews (2017)
Transport of cyclic nucleotides and estradiol 17-beta-D-glucuronide by multidrug resistance protein 4. Resistance to 6-mercaptopurine and 6-thioguanine.
Zhe-Sheng Chen;Kun Lee;Gary D. Kruh.
Journal of Biological Chemistry (2001)
Copper-transporting P-type adenosine triphosphatase (ATP7B) is associated with cisplatin resistance
Masaharu Komatsu;Tomoyuki Sumizawa;Masato Mutoh;Zhe-Sheng Chen.
Cancer Research (2000)
Transport of methotrexate, methotrexate polyglutamates, and 17β-estradiol 17-(β-D-glucuronide) by ABCG2: Effects of acquired mutations at R482 on methotrexate transport
Zhe Sheng Chen;Robert W. Robey;Martin G. Belinsky;Irina Shchaveleva.
Cancer Research (2003)
Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system.
Zhe-Sheng Chen;Kun Lee;Susan Walther;Rebecca Blanchard Raftogianis.
Cancer Research (2002)
Lapatinib (Tykerb, GW572016) Reverses Multidrug Resistance in Cancer Cells by Inhibiting the Activity of ATP-Binding Cassette Subfamily B Member 1 and G Member 2
Chun Ling Dai;Amit K. Tiwari;Chung Pu Wu;Xiao Dong Su.
Cancer Research (2008)
Transport of Methotrexate (MTX) and Folates by Multidrug Resistance Protein (MRP) 3 and MRP1 Effect of Polyglutamylation on MTX Transport
Hao Zeng;Zhe-Sheng Chen;Martin G. Belinsky;Philip A. Rea.
Cancer Research (2001)
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