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Molecular Biology
Netherlands
2026
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Genetics and Molecular Biology
Netherlands
2024

D-Index & Metrics

Molecular Biology

D-Index
152
Citations
77743
World Ranking
81
National Ranking
2

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in Netherlands Leader Award
  • 2025 - Research.com Molecular Biology in Netherlands Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in Netherlands Leader Award
  • 2023 - Research.com Molecular Biology in Netherlands Leader Award
  • 2022 - Research.com Genetics and Molecular Biology in Netherlands Leader Award
  • 1995 - Fellow of the American Academy of Arts and Sciences
  • 1992 - Robert Koch Gold Medal
  • 1991 - Member of the National Academy of Sciences
  • 1989 - Member of Academia Europaea
  • 1986 - Fellow of the Royal Society, United Kingdom
  • 1984 - Paul Ehrlich and Ludwig Darmstaedter Prize
  • 1978 - Royal Netherlands Academy of Arts and Sciences
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Piet Borst is affiliated with the Antoni van Leeuwenhoek Hospital in the Netherlands. Their research spans several fields, with a primary focus on Medicine and Biochemistry, Genetics and Molecular Biology. Within these broader areas, Borst's work addresses subfields such as Clinical Biochemistry, Molecular Biology, Cardiology and Cardiovascular Medicine, Cancer Research, and Oncology.

The scientist's research topics include Metabolism and Genetic Disorders, Mitochondrial Function and Pathology, Cancer, Hypoxia, and Metabolism, Drug Transport and Resistance Mechanisms, HIV/AIDS drug development and treatment, Trace Elements in Health, and Cardiovascular Function and Risk Factors.

Among frequent collaborators are Ben N. Schmermund, Andreas Rieth, Matthias Rademann, Steffen D. Kriechbaum, and Jan Sebastian Wolter.

Piet Borst has contributed to several peer-reviewed papers, including:

  • The malate-aspartate shuttle (Borst cycle): How it started and developed into a major metabolic pathway, 2020, IUBMB Life
  • Looking back at multidrug resistance (MDR) research and ten mistakes to be avoided when writing about ABC transporters in MDR, 2020, FEBS Letters
  • Abnormal Left Atrial Strain by CMR Is Associated With Left Heart Disease in Patients With Pulmonary Hypertension, 2025, Circulation Heart Failure
  • Adventures With Parasites, Metabolism, Inborn Errors, and Cancer, 2023, JAMA

The venues in which Borst frequently publishes include:

  • IUBMB Life
  • FEBS Letters
  • Circulation Heart Failure
  • JAMA

Over the course of their career, Borst has received various recognitions and awards. These include election as a Fellow of the American Academy of Arts and Sciences in 1995, the Robert Koch Gold Medal in 1992, membership in the National Academy of Sciences in 1991, membership in Academia Europaea in 1989, and fellowship with the Royal Society in the United Kingdom since 1986.

Additional honors include the Paul Ehrlich and Ludwig Darmstaedter Prize awarded in 1984, election to the Royal Netherlands Academy of Arts and Sciences in 1978, and membership in the European Molecular Biology Organization (EMBO).

Best Publications

  • Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

    A.H. Schinkel;J.J.M. Smit;O. van Tellingen;J.H. Beijnen

  • A Family of Drug Transporters: the Multidrug Resistance-Associated Proteins

    Piet Borst;Raymond Evers;Marcel Kool;Jan Wijnholds

  • Mammalian ABC Transporters in Health and Disease

    P. Borst;R.P.J. Oude Elferink

  • Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

    J.J.M. Smit;A.H. Schinkel;R.P.J.Oude Elferink;A.K. Groen

  • Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

    A. H. Schinkel;E. Wagenaar;L. Van Deemter;C. A. A. M. Mol

  • Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

    A. H. Schinkel;U. Mayer;E. Wagenaar;C. A. A. M. Mol

  • Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines.

    M. Kool;M. De Haas;G. L. Scheffer;R. J. Scheper

  • Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

    A. Sparreboom;J. van Asperen;U. Mayer;A.H. Schinkel

  • MDR1 P-Glycoprotein Is a Lipid Translocase of Broad Specificity, While MDR3 P-Glycoprotein Specifically Translocates Phosphatidylcholine

    Ardy van Helvoort;Alexander J Smith;Hein Sprong;Ingo Fritzsche

  • High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

    Sven Rottenberg;Janneke E. Jaspers;Ariena Kersbergen;Eline van der Burg

  • Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene.

    Coen C. Paulusma;Piter J. Bosma;Guido J. R. Zaman;Conny T. M. Bakker

  • The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump.

    G.J.R. Zaman;M.J. Flens;M.R. van Leusden;M. de Haas

  • The multidrug resistance protein family.

    Piet Borst;Raymond Evers;Marcel Kool;Jan Wijnholds

  • MRP3, an organic anion transporter able to transport anti-cancer drugs

    M. Kool;M. van der Linden;M. de Haas;G. L. Scheffer

  • Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport

    M. Muller;C. Meijer;G. J. R. Zaman;P. Borst

  • A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome.

    C. C. Paulusma;M. Kool;P. J. Bosma;G. L. Scheffer

  • The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs.

    Glen Reid;Pieter Wielinga;Noam Zelcer;Ingrid van der Heijden

  • Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein

    G J Zaman;J Lankelma;O van Tellingen;J Beijnen

  • Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA.

    R. Evers;M. Kool;L. Van Deemter;H. Janssen

  • Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs

    J Wijnholds;C A Mol;L van Deemter;M de Haas

Frequent Co-Authors

Sven Rottenberg
Sven Rottenberg University of Bern
Alfred H. Schinkel
Alfred H. Schinkel Antoni van Leeuwenhoek Hospital
Jos Jonkers
Jos Jonkers Antoni van Leeuwenhoek Hospital
Jan Wijnholds
Jan Wijnholds Leiden University Medical Center
Paul A. M. Michels
Paul A. M. Michels University of Edinburgh
Jos H. Beijnen
Jos H. Beijnen Utrecht University
Frank Baas
Frank Baas Leiden University Medical Center
Leslie A. Grivell
Leslie A. Grivell University of Amsterdam
Marina Pajic
Marina Pajic Garvan Institute of Medical Research
George L. Scheffer
George L. Scheffer VU University Medical Center

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