What is he best known for?
The fields of study he is best known for:
Piet Borst mostly deals with Biochemistry, Molecular biology, Gene, P-glycoprotein and Genetics.
His is doing research in Multidrug resistance-associated protein 2, Glutathione, ATP-binding cassette transporter, Peroxisome and Nucleotide, both of which are found in Biochemistry.
His Molecular biology research is multidisciplinary, relying on both Restriction enzyme, DNA, Transfection and Promoter, General transcription factor.
His DNA study integrates concerns from other disciplines, such as Electrophoresis, RNA, Trypanosoma brucei, Chromosome and Agarose.
His P-glycoprotein research includes themes of Internal medicine, Endocrinology and Phosphatidylcholine.
While the research belongs to areas of Multiple drug resistance, Piet Borst spends his time largely on the problem of Pharmacology, intersecting his research to questions surrounding Drug resistance, Efflux, In vivo and Excretion.
His most cited work include:
- Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs (1972 citations)
- A Family of Drug Transporters: the Multidrug Resistance-Associated Proteins (1450 citations)
- Mammalian ABC Transporters in Health and Disease (1302 citations)
What are the main themes of his work throughout his whole career to date?
His primary areas of investigation include Molecular biology, Gene, Biochemistry, DNA and Genetics.
The Molecular biology study which covers Transcription that intersects with Promoter.
Biochemistry is represented through his Mitochondrion, ATP-binding cassette transporter, Multidrug resistance-associated protein 2, Nucleotide and Microbody research.
Piet Borst interconnects Nuclear DNA, Mitochondrial DNA and Base J in the investigation of issues within DNA.
In the field of Genetics, his study on Genome, Gene cluster, Chromosome and Nucleic acid sequence overlaps with subjects such as Transposition.
The various areas that Piet Borst examines in his Trypanosoma brucei study include Telomere, Peptide sequence, Glycoprotein and Trypanosoma.
He most often published in these fields:
- Molecular biology (41.72%)
- Gene (30.94%)
- Biochemistry (30.34%)
What were the highlights of his more recent work (between 2004-2020)?
- Biochemistry (30.34%)
- Cancer research (6.39%)
- Cancer (3.39%)
In recent papers he was focusing on the following fields of study:
His main research concerns Biochemistry, Cancer research, Cancer, Pharmacology and Molecular biology.
Biochemistry is frequently linked to In vivo in his study.
His research in Cancer research intersects with topics in Cisplatin, Immunology, Doxorubicin, Docetaxel and Drug resistance.
His Pharmacology research incorporates elements of Metabolite, P-glycoprotein, Epithelial polarity and Abcg2.
His Molecular biology study incorporates themes from Transcription, Gene, Transfection, DNA and Cell biology.
Piet Borst works mostly in the field of DNA, limiting it down to concerns involving Nuclear DNA and, occasionally, Trypanosoma brucei.
Between 2004 and 2020, his most popular works were:
- High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs (664 citations)
- REV7 counteracts DNA double-strand break resection and affects PARP inhibition (324 citations)
- Loss of 53BP1 Causes PARP Inhibitor Resistance in Brca1-Mutated Mouse Mammary Tumors (304 citations)
In his most recent research, the most cited papers focused on:
His scientific interests lie mostly in Pharmacology, Biochemistry, Cancer research, In vivo and Cisplatin.
His Pharmacology study combines topics in areas such as Transporter, Epithelial polarity, Abcg2 and Multiple drug resistance.
His research related to Nucleotide, Metabolite, Metabolism, Multidrug resistance-associated protein 2 and Multidrug Resistance-Associated Proteins might be considered part of Biochemistry.
His work carried out in the field of Cisplatin brings together such families of science as Drug resistance, Docetaxel and Doxorubicin.
The Poly Polymerase Inhibitor study combines topics in areas such as Molecular biology, Cancer, Olaparib and Homologous recombination.
His biological study spans a wide range of topics, including Nuclear DNA and Base J.
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