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Biology and Biochemistry

D-Index
75
Citations
28122
World Ranking
5218
National Ranking
399

Overview

Paul A. M. Michels is affiliated with the University of Edinburgh in the United Kingdom. Their research primarily spans the fields of biochemistry, genetics, molecular biology, and medicine, with significant focus on molecular biology, epidemiology, physiology, public health, environmental and occupational health, and parasitology.

The scientist's research covers a variety of biochemical and molecular topics related to parasitic organisms, metabolic processes, and disease mechanisms. Key research themes include Trypanosoma species, biochemical and molecular research, studies on leishmaniasis, lysosomal storage disorders, metabolomics and mass spectrometry, calcium signaling, nucleotide metabolism, and mitochondrial function and pathology.

Frequent coauthors who have collaborated with Michels include Wilfredo Quiñones, Malcolm D. Walkinshaw, Maura Rojas-Pirela, Diego Andrade-Alviárez, and Meng Yuan.

Notable frequent venues for publication include:

  • Experimental Parasitology
  • Open Biology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Cellular and Infection Microbiology
  • Metabolomics

Selected recent papers authored or coauthored by Michels include:

  • Carbohydrate metabolism in trypanosomatids: New insights revealing novel complexity, diversity and species-unique features (2021), Experimental Parasitology
  • Phosphoglycerate kinase: structural aspects and functions, with special emphasis on the enzyme from Kinetoplastea (2020), Open Biology
  • Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches (2020), Biochemical Journal
  • Structure, Properties, and Function of Glycosomes in Trypanosoma cruzi (2020), Frontiers in Cellular and Infection Microbiology
  • Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice (2021), Nature Communications

Michels has also contributed to book publications, including a title published by Springer Science+Business Media:

  • Trypanosomatids (2020)

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

    Daniel J. Klionsky;Hagai Abeliovich;Patrizia Agostinis;Devendra K. Agrawal

  • Evolution of glycolysis.

    Linda A. Fothergill-Gilmore;Paul A.M. Michels

  • 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis

    Mark H. Rider;Luc Bertrand;Didier Vertommen;Paul A. Michels

  • Metabolic functions of glycosomes in trypanosomatids.

    Paul A.M. Michels;Frédéric Bringaud;Murielle Herman;Véronique Hannaert

  • Glycolysis as a target for the design of new anti-trypanosome drugs

    Christophe L.M.J. Verlinde;Véronique Hannaert;Casimir Blonski;Michèle Willson

  • Growth of chromosome ends in multiplying trypanosomes

    André Bernards;André Bernards;Paul A. M. Michels;Paul A. M. Michels;Carsten R. Lincke;Piet Borst

  • Glycolysis in Bloodstream Form Trypanosoma brucei Can Be Understood in Terms of the Kinetics of the Glycolytic Enzymes

    Barbara M. Bakker;Barbara M. Bakker;Paul A.M. Michels;Fred R. Opperdoes;Hans V. Westerhoff

  • Plant-like traits associated with metabolism of Trypanosoma parasites.

    Véronique Hannaert;Emma Saavedra;Francis Duffieux;Jean-Pierre Szikora

  • Synergistic effects of substrate-induced conformational changes in phosphoglycerate kinase activation

    Bradley E. Bernstein;Paul A. M. Michels;Wim G. J. Hol

  • What Controls Glycolysis in Bloodstream Form Trypanosoma brucei

    Barbara M. Bakker;Barbara M. Bakker;Paul A.M. Michels;Fred R. Opperdoes;Hans V. Westerhoff;Hans V. Westerhoff

  • Compartmentation protects trypanosomes from the dangerous design of glycolysis

    BM Bakker;Fic Mensonides;B Teusink;P van Hoek

  • Generation of an electrochemical proton gradient in bacteria by the excretion of metabolic end products

    Paul A.M. Michels;Jan P.J. Michels;Johannes Boonstra;Wil N. Konings

  • Experimental and in Silico Analyses of Glycolytic Flux Control in Bloodstream Form Trypanosoma brucei

    Marie Astrid Albert;Jurgen R. Haanstra;Véronique Hannaert;Joris Van Roy

  • Roles of triosephosphate isomerase and aerobic metabolism in Trypanosoma brucei.

    Sandra Helfert;Antonio M. Estévez;Barbara Bakker;Barbara Bakker;Paul Michels

  • RNA splicing is required to make the messenger RNA for a variant surface antigen in trypanosomes

    L. H. T. Van der Ploeg;A. Y. C. Liu;P. A. M. Michels;T. De Lange

  • Chromosome rearrangements in Trypanosoma brucei.

    Lex H.T. Van der Ploeg;Albert W.C.A. Cornelissen;Paul A.M. Michels;Piet Borst

  • Autophagy in protists

    Michael Duszenko;Michael L Ginger;Ana Brennand;Melisa Gualdrón-López

  • Compartmentation prevents a lethal turbo-explosion of glycolysis in trypanosomes.

    Jurgen R. Haanstra;Arjen van Tuijl;Peter Kessler;Willem Reijnders

  • Metabolic control analysis of glycolysis in trypanosomes as an approach to improve selectivity and effectiveness of drugs

    Barbara M Bakker;Hans V Westerhoff;Hans V Westerhoff;Fred R Opperdoes;Paul A.M Michels

Frequent Co-Authors

Malcolm D. Walkinshaw
Malcolm D. Walkinshaw University of Edinburgh
Fred R. Opperdoes
Fred R. Opperdoes Université Catholique de Louvain
Anton Simeonov
Anton Simeonov National Institutes of Health
Daniel J. Rigden
Daniel J. Rigden University of Liverpool
Barbara M. Bakker
Barbara M. Bakker University Medical Center Groningen
Piet Borst
Piet Borst Antoni van Leeuwenhoek Hospital
Frédéric Bringaud
Frédéric Bringaud University of Bordeaux
Wim G. J. Hol
Wim G. J. Hol University of Washington
Hans V. Westerhoff
Hans V. Westerhoff Vrije Universiteit Amsterdam
Kiyoshi Kita
Kiyoshi Kita Nagasaki University

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