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Molecular Biology

D-Index
52
Citations
10081
World Ranking
2433
National Ranking
1197

Overview

Marilyn Parsons is affiliated with the University of Washington in the United States. Their research spans several key fields including Medicine and Biochemistry, Genetics and Molecular Biology, with specific subfields in Epidemiology, Public Health, Environmental and Occupational Health, Molecular Biology, Physiology, and Parasitology.

The scientist's body of work focuses heavily on parasitic diseases, particularly the study of Trypanosoma species and Leishmaniasis. Their research interests also extend to topics such as insect resistance and genetics, Toxoplasma gondii studies, autophagy in disease and therapy, heme oxygenase-1 and carbon monoxide, as well as calcium signaling and nucleotide metabolism.

Key recent research papers by Marilyn Parsons include:

  • "Chromatin-Associated Protein Complexes Link DNA Base J and Transcription Termination in Leishmania," (2021) published in mSphere
  • "Unusual features and localization of the membrane kinome of Trypanosoma brucei," (2021) published in PLoS ONE
  • "Chromatin-associated protein complexes link DNA base J and transcription termination inLeishmania," (2020) published in bioRxiv (Cold Spring Harbor Laboratory)
  • "Unusual Features of the Membrane Kinome ofTrypanosoma brucei," (2020) published in bioRxiv (Cold Spring Harbor Laboratory)
  • "An essential Trypanosoma brucei protein kinase: a functional analysis of regulation and the identification of inhibitors," (2023) published in Frontiers in Parasitology

Frequent coauthors in Parsons's work include:

  • Bryan C. Jensen
  • Isabelle Coppens
  • Isabelle Phan
  • Jacquelyn McDonald
  • Aakash Sur

Their research has been published in various venues, notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • mSphere
  • PLoS ONE
  • Frontiers in Parasitology

Marilyn Parsons's academic contributions reflect a sustained investigation into molecular and cellular mechanisms underlying parasitic infections. The work includes exploring protein complexes linked to DNA transcription regulation and kinase functions critical in Trypanosoma brucei, a pathogen responsible for significant tropical diseases.

Best Publications

  • The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease

    Najib M. El-Sayed;Peter J. Myler;Peter J. Myler;Daniella C. Bartholomeu;Daniel Nilsson

  • Comparative genomics of trypanosomatid parasitic protozoa.

    Najib M. El-Sayed;Peter J. Myler;Peter J. Myler;Gaëlle Blandin;Matthew Berriman

  • Comparative analysis of the kinomes of three pathogenic trypanosomatids: Leishmania major, Trypanosoma brucei and Trypanosoma cruzi.

    Marilyn Parsons;Marilyn Parsons;Elizabeth A Worthey;Pauline N Ward;Jeremy C Mottram

  • A glycolipid antigen associated with Burkitt lymphoma defined by a monoclonal antibody.

    E Nudelman;R Kannagi;S Hakomori;M Parsons

  • Protein kinases as drug targets in trypanosomes and Leishmania.

    Christina Naula;Marilyn Parsons;Marilyn Parsons;Jeremy C. Mottram

  • Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors.

    Kayode K Ojo;Eric T Larson;Katelyn R Keyloun;Lisa J Castaneda

  • Compartmentation prevents a lethal turbo-explosion of glycolysis in trypanosomes.

    Jurgen R. Haanstra;Arjen van Tuijl;Peter Kessler;Willem Reijnders

  • Trypanosome mRNAs share a common 5′ spliced leader sequence

    Marilyn Parsons;Richard G. Nelson;Kenneth P. Watkins;Nina Agabian

  • Widespread variation in transcript abundance within and across developmental stages of Trypanosoma brucei

    Bryan C Jensen;Dhileep Sivam;Dhileep Sivam;Charles T Kifer;Peter J Myler;Peter J Myler

  • Analysis of targeting sequences demonstrates that trafficking to the Toxoplasma gondii plastid branches off the secretory system.

    Amy DeRocher;Christopher B. Hagen;John E. Froehlich;Jean E. Feagin

  • Sequences homologous to the variant antigen mRNA spliced leader are located in tandem repeats and variable orphons in trypanosoma brucei.

    Richard G. Nelson;Marilyn Parsons;Philip J. Barr;Kenneth Stuart

  • Glucose is toxic to glycosome-deficient trypanosomes

    Tetsuya Furuya;Peter Kessler;Armando Jardim;Achim Schnaufer

  • Extensive stage-regulation of translation revealed by ribosome profiling of Trypanosoma brucei

    Bryan C Jensen;Gowthaman Ramasamy;Elton J R Vasconcelos;Nicholas T Ingolia

  • Biogenesis and function of peroxisomes and glycosomes

    Marilyn Parsons;Tetsuya Furuya;Tetsuya Furuya;Sampa Pal;Sampa Pal;Peter Kessler;Peter Kessler

  • Development of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) inhibitors with potent anti-toxoplasma activity.

    Steven M Johnson;Ryan C Murphy;Jennifer A Geiger;Amy E DeRocher

  • Pathways involved in environmental sensing in trypanosomatids.

    Marilyn Parsons;Larry Ruben

  • Glycosomes: parasites and the divergence of peroxisomal purpose.

    Marilyn Parsons

  • The NOG1 GTP-binding protein is required for biogenesis of the 60 S ribosomal subunit.

    Bryan C. Jensen;Qin Wang;Qin Wang;Charles T. Kifer;Marilyn Parsons;Marilyn Parsons

  • Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis.

    Rama Subba Rao Vidadala;Kasey L. Rivas;Kayode K. Ojo;Matthew A. Hulverson

  • Cloning and expression of Trypanosoma cruzi ribosomal protein P0 and epitope analysis of anti-P0 autoantibodies in Chagas' disease patients.

    Yasir A W Skeiky;Darin R. Benson;Marilyn Parsons;Keith B. Elkon

Frequent Co-Authors

Peter J. Myler
Peter J. Myler Seattle Children's Hospital
Kenneth Stuart
Kenneth Stuart University of Washington
Wesley C. Van Voorhis
Wesley C. Van Voorhis University of Washington
Ethan A. Merritt
Ethan A. Merritt University of Washington
Ching C. Wang
Ching C. Wang University of California, San Francisco
Gary L. Schieven
Gary L. Schieven Genesis Biotechnology Group
Wim G. J. Hol
Wim G. J. Hol University of Washington
Nina Agabian
Nina Agabian University of California, San Francisco
Isabelle Coppens
Isabelle Coppens Johns Hopkins University
Jeremy C. Mottram
Jeremy C. Mottram University of York

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