Ethan A. Merritt

Best Publications

• Crystal structure of core streptavidin determined from multiwavelength anomalous diffraction of synchrotron radiation.

  W A Hendrickson;A Pähler;J L Smith;Y Satow

  893
  Citations

• Crystal structure of cholera toxin B‐pentamer bound to receptor GM1 pentasaccharide

  E. A. Merritt;S. Sarfaty;F. van den Akker;C. L'Hoir

  749
  Citations

• The 1.25 A resolution refinement of the cholera toxin B-pentamer: evidence of peptide backbone strain at the receptor-binding site.

  Ethan A Merritt;Peter Kuhn;Steve Sarfaty;Jarrod L Erbe

  217
  Citations

• Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors.

  Kayode K Ojo;Eric T Larson;Katelyn R Keyloun;Lisa J Castaneda

  197
  Citations

• Characterization and crystal structure of a high-affinity pentavalent receptor-binding inhibitor for cholera toxin and E. coli heat-labile enterotoxin.

  Ethan A. Merritt;Zhongsheng Zhang;Jason C. Pickens;Misol Ahn

  193
  Citations

• GALACTOSE-BINDING SITE IN ESCHERICHIA-COLI HEAT-LABILE ENTEROTOXIN (LT) AND CHOLERA-TOXIN (CT)

  E. A. Merritt;T. K. Sixma;K. H. Kalk;B. A. M. Van Zanten

  184
  Citations

• Crystallographic structure analysis of lamprey hemoglobin from anomalous dispersion of synchrotron radiation

  Wayne A. Hendrickson;Janet L. Smith;R. Paul Phizackerley;Ethan A. Merritt

  179
  Citations

• AB5 toxins: structures and inhibitor design

  Erkang Fan;Ethan A Merritt;Christophe Lmj Verlinde;Wim Gj Hol

  168
  Citations

• Solution and crystallographic studies of branched multivalent ligands that inhibit the receptor-binding of cholera toxin.

  Zhongsheng Zhang;Ethan A. Merritt;Misol Ahn;Claudia Roach

  160
  Citations

• A mutant cholera toxin B subunit that binds GM1- ganglioside but lacks immunomodulatory or toxic activity.

  A. T. Aman;S. Fraser;E. A. Merritt;C. Rodigherio

  148
  Citations

• Discovery of Potent and Selective Inhibitors of CDPK1 from C. parvum and T. gondii

  Ryan C. Murphy;Kayode K. Ojo;Eric T. Larson;Alejandro Castellanos-Gonzalez

  147
  Citations

• Structural studies of receptor binding by cholera toxin mutants.

  E. A. Merritt;S. Sarfaty;M. G. Jobling;T. Chang

  134
  Citations

• Development of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) inhibitors with potent anti-toxoplasma activity.

  Steven M Johnson;Ryan C Murphy;Jennifer A Geiger;Amy E DeRocher

  128
  Citations

• A molecular viewer for the analysis of TLS rigid-body motion in macromolecules.

  Jay Painter;Ethan A. Merritt

  124
  Citations

• High-resolution Structural and Thermodynamic Analysis of Extreme Stabilization of Human Procarboxypeptidase by Computational Protein Design

  Gautam Dantas;Colin Corrent;Steve L. Reichow;James J. Havranek

  120
  Citations

• Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors

  Kayode K. Ojo;Claudia Pfander;Natascha R. Mueller;Charlotte Burstroem

  117
  Citations

• Sequence determinants of a specific inactive protein kinase conformation.

  Sanjay B. Hari;Ethan A. Merritt;Dustin J. Maly

  116
  Citations

• Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis.

  Rama Subba Rao Vidadala;Kasey L. Rivas;Kayode K. Ojo;Matthew A. Hulverson

  115
  Citations

• Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies.

  Tracy L. Arakaki;Frederick S. Buckner;J. Robert Gillespie;Nicholas A. Malmquist

  96
  Citations

• Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei Infection in Mice.

  Sayaka Shibata;J. Robert Gillespie;Angela M. Kelley;Alberto J. Napuli

  89
  Citations