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Microbiology

D-Index
49
Citations
7710
World Ranking
4595
National Ranking
139

Overview

Timothy R. Hirst is affiliated with the University of Adelaide in Australia and has a research focus primarily in the field of Medicine. Their work covers a range of subfields including Epidemiology, Radiology, Nuclear Medicine and Imaging, Orthodontics, Computational Mechanics, and Microbiology.

Hirst's research addresses several main topics, which include:

  • Pneumonia and Respiratory Infections
  • Laser Applications in Dentistry and Medicine
  • Dental Materials and Restorations
  • Laser Material Processing Techniques
  • Bacterial Infections and Vaccines
  • Respiratory Viral Infections Research
  • Monoclonal and Polyclonal Antibodies Research

Among recent publications, notable papers authored or co-authored by Hirst include:

  • "Femtosecond laser dentistry for precise and efficient cavity preparation in teeth," published in 2022 in Biomedical Optics Express
  • "Sterility of gamma-irradiated pathogens: a new mathematical formula to calculate sterilizing doses," published in 2020 in Journal of Radiation Research
  • "Investigation of laser wavelength effect on the ablation of enamel and dentin using femtosecond laser pulses," published in 2023 in Scientific Reports
  • "A Nonadjuvanted Whole-Inactivated Pneumococcal Vaccine Induces Multiserotype Opsonophagocytic Responses Mediated by Noncapsule-Specific Antibodies," published in 2022 in mBio
  • "Enhanced Immunogenicity of a Whole-Inactivated Influenza A Virus Vaccine Using Optimised Irradiation Conditions," published in 2021 in Frontiers in Immunology

Frequent co-authorships in Hirst's research reflect collaborations with several other researchers, including:

  • Justin Davies
  • James C. Paton
  • Mohammed Alsharifi
  • Eve V. Singleton
  • Shannon C. David

Hirst's work has appeared in various academic venues, with multiple publications found in:

  • Zenodo (CERN European Organization for Nuclear Research)
  • Biomedical Optics Express
  • Scientific Reports
  • Journal of Radiation Research
  • mBio

Best Publications

  • Protein disulphide isomerase: building bridges in protein folding

    Robert B. Freedman;Timothy R. Hirst;Mick F. Tuite

  • Membrane traffic and the cellular uptake of cholera toxin.

    Wayne I. Lencer;Timothy R. Hirst;Randall K. Holmes

  • Targeting of cholera toxin and Escherichia coli heat labile toxin in polarized epithelia: role of COOH-terminal KDEL.

    W.I. Lencer;C. Constable;S. Moe;M.G. Jobling

  • Immune modulation by the cholera-like enterotoxins: from adjuvant to therapeutic

    Neil A Williams;Timothy R Hirst;Toufic O Nashar

  • Cholera toxin: a paradigm for multi-functional engagement of cellular mechanisms (Review).

    Lolke de Haan;Timothy R. Hirst

  • Conformation of protein secreted across bacterial outer membranes: a study of enterotoxin translocation from Vibrio cholerae

    Timothy R. Hirst;Jan Holmgren

  • Biofilm formation by Helicobacter pylori.

    R. M. Stark;G. J. Gerwig;R. S. Pitman;L. F. Potts

  • Potent immunogenicity of the B subunits of Escherichia coli heat-labile enterotoxin: receptor binding is essential and induces differential modulation of lymphocyte subsets.

    Toufic O. Nashar;Helen M. Webb;Simon S. Eaglestone;Neil A. Williams

  • Mechanism of toxin secretion by Vibrio cholerae investigated in strains harboring plasmids that encode heat-labile enterotoxins of Escherichia coli

    Timothy R. Hirst;Joaquin Sanchez;James B. Kaper;Simon J. S. Hardy

  • Coordinated assembly of multisubunit proteins: oligomerization of bacterial enterotoxins in vivo and in vitro.

    Simon J. S. Hardy;Jan Holmgren;Susanne Johansson;Joaquin Sanchez

  • A homologue of the Escherichia coli DsbA protein involved in disulphide bond formation is required for enterotoxin biogenesis in Vibrio cholerae.

    Jun Yu;Helen Webb;Timothy R. Hirst

  • Energy is Required for Maturation of Exported Proteins in Escherichia coli

    Hans G. Enequist;Timothy R. Hirst;Shigeaki Harayama;Simon J. S. Hardy

  • Investigations into the mechanism of action of the antibacterial agent norfloxacin.

    G. C. Crumplin;Marion Kenwright;T. Hirst

  • A mutant cholera toxin B subunit that binds GM1- ganglioside but lacks immunomodulatory or toxic activity.

    A. T. Aman;S. Fraser;E. A. Merritt;C. Rodigherio

  • Escherichia coli Heat-Labile Enterotoxin B Subunit Is a More Potent Mucosal Adjuvant than Its Closely Related Homologue, the B Subunit of Cholera Toxin

    Douglas G. Millar;Timothy R. Hirst;Denis P. Snider

  • Structural studies of receptor binding by cholera toxin mutants.

    E. A. Merritt;S. Sarfaty;M. G. Jobling;T. Chang

  • pH-dependence of the dithiol-oxidizing activity of DsbA (a periplasmic protein thiol:disulphide oxidoreductase) and protein disulphide-isomerase: studies with a novel simple peptide substrate

    Lloyd W. Ruddock;Timothy R. Hirst;Robert B. Freedman

  • Transient entry of enterotoxin subunits into the periplasm occurs during their secretion from Vibrio cholerae.

    T R Hirst;J Holmgren

  • F-actin dynamics control segregation of the TCR signaling cascade to clustered lipid rafts.

    Silvia Valensin;Silvia Rossi Paccani;Cristina Ulivieri;David Mercati

  • Cellular location of heat-labile enterotoxin in Escherichia coli.

    T R Hirst;L L Randall;S J Hardy

Frequent Co-Authors

Wayne I. Lencer
Wayne I. Lencer Harvard University
Giorgio Palù
Giorgio Palù University of Padua
Robert B. Freedman
Robert B. Freedman University of Warwick
Jun Yu
Jun Yu Chinese University of Hong Kong
Randall K. Holmes
Randall K. Holmes University of Colorado Denver
Lloyd W. Ruddock
Lloyd W. Ruddock University of Oulu
Jan Holmgren
Jan Holmgren University of Gothenburg
Wim G. J. Hol
Wim G. J. Hol University of Washington
Ethan A. Merritt
Ethan A. Merritt University of Washington
Emanuele Papini
Emanuele Papini University of Padua

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